scholarly journals Sustained Virological Response after Early Antiviral Treatment of Acute Hepatitis C Virus and HIV Coinfection

2009 ◽  
Vol 49 (3) ◽  
pp. 466-472 ◽  
Author(s):  
Julian Schulze zur Wiesch ◽  
Dorothea Pieper ◽  
Ingrid Stahmer ◽  
Thomas Eiermann ◽  
Peter Buggisch ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Antiviral Treatment ◽  
Acute Hepatitis C ◽  
Hiv Coinfection

Liver Stiffness–Based Strategies Predict Absence of Variceal Bleeding in Cirrhotic Hepatitis C Virus–Infected Patients With and Without Human Immunodeficiency Virus Coinfection After Sustained Virological Response

2020 ◽  
Author(s):  
Anaïs Corma-Gómez ◽  
Juan Macías ◽  
Luis Morano ◽  
Antonio Rivero ◽  
Francisco Téllez ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Variceal Bleeding ◽  
Liver Stiffness ◽  
Low Risk ◽  
Hiv Coinfection ◽  
Immunodeficiency Virus

Abstract Background In the setting of hepatitis C virus (HCV) active infection, liver stiffness (LS)–based strategies identify patients with low risk of developing esophageal variceal bleeding (VB) episodes, in whom unnecessary upper esophagogastroduodenoscopy (UGE) screening can be safely avoided. However, after sustained virological response (SVR), data on the accuracy of the criteria predicting this outcome in HCV-infected patients with cirrhosis, with or without human immunodeficiency virus (HIV) coinfection, are very limited. Methods This was a multicenter prospective cohort study, where HCV-monoinfected patients and HIV/HCV-coinfected individuals were included if they had (1) SVR with direct-acting antiviral–based therapy; (2) LS ≥9.5 kPa previous to treatment; and (3) LS measurement at the SVR time-point ≥14 kPa. Diagnostic accuracy of HEPAVIR, expanded Baveno VI, and HIV cirrhosis criteria, at the time of SVR, was evaluated. Missed VB episodes, negative predictive values (NPVs), and number of spared UGEs were specifically assessed. Results Four hundred thirty-five patients were included, 284 (65%) coinfected with HIV. Seven (1.6%) patients developed a first episode of VB after SVR. In patients without a previous VB episode, HEPAVIR, expanded Baveno VI and HIV cirrhosis criteria achieved NPV for first VB episode after SVR of 99.5% (95% confidence interval [CI], 97.1%–100%), 100% (95% CI 97.8%–100%), and 100% (95% CI 98%–100%) while sparing 45%, 39%, and 44% of UGEs, respectively. When considering HIV coinfection, the performance of the 3 criteria was similar, both in HCV-monoinfected and HIV/HCV-coinfected individuals. Conclusions After SVR, predictive LS-based strategies accurately identify HCV-infected patients, HIV coinfected or not, with low risk of developing VB during follow-up. In these specific patients, using HIV cirrhosis criteria maximize the number of spared UGEs while missing no VB episode.

scholarly journals Marijuana Use in Hepatitis C Infection does not Affect Liver Biopsy Histology or Treatment Outcomes

2014 ◽  
Vol 28 (7) ◽  
pp. 381-384 ◽  
Author(s):  
Theresa Liu ◽  
Glen T Howell ◽  
Lucy Turner ◽  
Kimberley Corace ◽  
Gary Garber ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Biopsy ◽  
Viral Hepatitis ◽  
Treatment Outcomes ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Antiviral Treatment ◽  
Marijuana Use ◽  
Ottawa Hospital

BACKGROUND: Marijuana smoking is prevalent among hepatitis C virus-infected patients. The literature assessing the influence of marijuana on liver disease progression and hepatitis C virus antiviral treatment outcomes is conflicting.METHODS: The authors evaluated hepatitis C virus RNA-positive patients followed at The Ottawa Hospital Viral Hepatitis Clinic (Ottawa, Ontario) from 2000 to 2009. Using The Ottawa Hospital Viral Hepatitis Clinic database and charts, information regarding demographics, HIV coinfection, alcohol use, liver biopsy results, treatment outcomes and self-reported marijuana use was extracted. Biopsy characteristics and hepatitis C virus antiviral treatment outcomes were assessed for association with categorized marijuana use by adjusted logistic regression; covariates were specified according to clinical relevance a priori.RESULTS: Information regarding marijuana use was available for 550 patients, 159 (28.9%) of whom were using marijuana at the time of first assessment. Biopsy fibrosis stage and marijuana use data were available for 377 of these 550 (F0-2=72.3%). Overall, marijuana use did not predict fibrosis stage, inflammation grade or steatosis. Sustained virological response and marijuana use data were available for 359 of the 550 cohort participants; a total of 211 (58.8%) achieved a sustained virological response. Marijuana use was not associated with premature interruption of therapy for side effects, the likelihood of completing a full course of therapy or sustained virological response.CONCLUSION: Marijuana use did not influence biopsy histology or alter key hard outcomes of hepatitis C virus antiviral therapy.

scholarly journals Acute hepatitis C virus (HCV) infection in the setting of HIV coinfection: a single-centre 10-year follow-up

2014 ◽  
Vol 17 ◽  
pp. 19638 ◽  
Author(s):  
Patrick Ingiliz ◽  
Katharina Steininger ◽  
Marcel Schuetze ◽  
Stephan Dupke ◽  
Andreas Carganico ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Hcv Infection ◽  
Acute Hepatitis C ◽  
Single Centre ◽  
Hiv Coinfection

Direct-acting antiviral treatment of acute hepatitis C virus infections

2018 ◽  
Vol 16 (8) ◽  
pp. 599-610 ◽  
Author(s):  
Suresh Misra ◽  
Douglas T. Dieterich ◽  
Behnam Saberi ◽  
Tatyana Kushner
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Antiviral Treatment ◽  
Acute Hepatitis C ◽  
Virus Infections ◽  
Direct Acting Antiviral ◽  
Direct Acting

Low Rate of Sustained Virological Response in an Outbreak of Acute Hepatitis C in HIV-Infected Patients

2012 ◽  
Vol 28 (10) ◽  
pp. 1294-1300 ◽  
Author(s):  
Montserrat Laguno ◽  
Maria Martínez-Rebollar ◽  
Iñaki Perez ◽  
Josep Costa ◽  
Maria Larrousse ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Acute Hepatitis C ◽  
Low Rate
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