scholarly journals Risk Factors Associated with Subclinical Human Infection with Avian Influenza A (H5N1) Virus—Cambodia, 2006

2009 ◽  
Vol 199 (12) ◽  
pp. 1744-1752 ◽  
Author(s):  
Sirenda Vong ◽  
Sowath Ly ◽  
Maria D. Van Kerkhove ◽  
Jenna Achenbach ◽  
Davun Holl ◽  
...  
Keyword(s):  
Risk Factors ◽  
Avian Influenza ◽  
Influenza A ◽  
H5n1 Virus ◽  
Human Infection ◽  
Factors Associated

scholarly journals Risk Factors for Human Illness with Avian Influenza A (H5N1) Virus Infection in China

2009 ◽  
Vol 199 (12) ◽  
pp. 1726-1734 ◽  
Author(s):  
Lei Zhou ◽  
Qiaohong Liao ◽  
Libo Dong ◽  
Yang Huai ◽  
Tian Bai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Virus Infection ◽  
Avian Influenza ◽  
Influenza A ◽  
H5n1 Virus ◽  
Human Illness

scholarly journals Factors Associated With Fatality Due to Avian Influenza A(H7N9) Infection in China

2019 ◽  
Vol 71 (1) ◽  
pp. 128-132 ◽  
Author(s):  
Shufa Zheng ◽  
Qianda Zou ◽  
Xiaochen Wang ◽  
Jiaqi Bao ◽  
Fei Yu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Avian Influenza ◽  
Influenza A ◽  
Bacterial Infections ◽  
Neuraminidase Inhibitor ◽  
Inhibitor Therapy ◽  
H7n9 Virus ◽  
Factors Associated ◽  
Risk Of Death ◽  
Increased Risk

Abstract Background The high case fatality rate of influenza A(H7N9)-infected patients has been a major clinical concern. Methods To identify the common causes of death due to H7N9 as well as identify risk factors associated with the high inpatient mortality, we retrospectively collected clinical treatment information from 350 hospitalized human cases of H7N9 virus in mainland China during 2013–2017, of which 109 (31.1%) had died, and systematically analyzed the patients’ clinical characteristics and risk factors for death. Results The median age at time of infection was 57 years, whereas the median age at time of death was 61 years, significantly older than those who survived. In contrast to previous studies, we found nosocomial infections comprising Acinetobacter baumannii and Klebsiella most commonly associated with secondary bacterial infections, which was likely due to the high utilization of supportive therapies, including mechanical ventilation (52.6%), extracorporeal membrane oxygenation (14%), continuous renal replacement therapy (19.1%), and artificial liver therapy (9.7%). Age, time from illness onset to antiviral therapy initiation, and secondary bacterial infection were independent risk factors for death. Age >65 years, secondary bacterial infections, and initiation of neuraminidase-inhibitor therapy after 5 days from symptom onset were associated with increased risk of death. Conclusions Death among H7N9 virus–infected patients occurred rapidly after hospital admission, especially among older patients, followed by severe hypoxemia and multisystem organ failure. Our results show that early neuraminidase-inhibitor therapy and reduction of secondary bacterial infections can help reduce mortality. Characterization of 350 hospitalized avian influenza A(H7N9)-infected patients in China shows that age >65 years, secondary bacterial infections, and initiation of neuraminidase-inhibitor therapy after 5 days from symptom onset were associated with increased risk of death.

Pathology of fatal human infection associated with avian influenza A H5N1 virus

2001 ◽  
Vol 63 (3) ◽  
pp. 242-246 ◽  
Author(s):  
Ka-Fai To ◽  
Paul K.S. Chan ◽  
Kui-Fat Chan ◽  
Wai-Ki Lee ◽  
Woon-Yee Lam ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
H5n1 Virus ◽  
Human Infection

scholarly journals Risk Factors for Human Infection with Avian Influenza A H5N1, Vietnam, 2004

2006 ◽  
Vol 12 (12) ◽  
pp. 1841-1847 ◽  
Author(s):  
Pham Dinh ◽  
Hoang Long ◽  
Nguyen Tien ◽  
Nguyen Hien ◽  
Le Mai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Avian Influenza ◽  
Influenza A ◽  
Human Infection

Identification of meteorological factors associated with human infection with avian influenza A H7N9 virus in Zhejiang Province, China

2018 ◽  
Vol 644 ◽  
pp. 696-709 ◽  
Author(s):  
Steven Yuk-Fai Lau ◽  
Xiaoxiao Wang ◽  
Maggie Wang ◽  
Shelan Liu ◽  
Benny Chung-Ying Zee ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
Meteorological Factors ◽  
Human Infection ◽  
Zhejiang Province ◽  
H7n9 Virus ◽  
Factors Associated

scholarly journals WHO Rapid Advice Guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virus

2007 ◽  
Vol 7 (1) ◽  
pp. 21-31 ◽  
Author(s):  
Holger J Schünemann ◽  
Suzanne R Hill ◽  
Meetali Kakad ◽  
Richard Bellamy ◽  
Timothy M Uyeki ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
H5n1 Virus ◽  
Human Infection ◽  
Pharmacological Management

Case-control study of risk factors for human infection with avian influenza A(H7N9) virus in Shanghai, China, 2013

2014 ◽  
Vol 143 (9) ◽  
pp. 1826-1832 ◽  
Author(s):  
J. LI ◽  
J. CHEN ◽  
G. YANG ◽  
Y. X. ZHENG ◽  
S. H. MAO ◽  
...  
Keyword(s):  
Risk Factors ◽  
Avian Influenza ◽  
Influenza A ◽  
Case Control Study ◽  
Case Control ◽  
Human Infection ◽  
H7n9 Virus ◽  
Live Poultry ◽  
H7n9 Infection ◽  
Control Study

SUMMARYThe first human infection with avian influenza A(H7N9) virus was reported in Shanghai, China in March 2013. An additional 32 cases of human H7N9 infection were identified in the following months from March to April 2013 in Shanghai. Here we conducted a case-control study of the patients with H7N9 infection (n = 25) using controls matched by age, sex, and residence to determine risk factors for H7N9 infection. Our findings suggest that chronic disease and frequency of visiting a live poultry market (>10 times, or 1–9 times during the 2 weeks before illness onset) were likely to be significantly associated with H7N9 infection, with the odds ratios being 4·07 [95% confidence interval (CI) 1·32–12·56], 10·61 (95% CI 1·85–60·74), and 3·76 (95% CI 1·31–10·79), respectively. Effective strategies for live poultry market control should be reinforced and ongoing education of the public is warranted to promote behavioural changes that can help to eliminate direct or indirect contact with influenza A(H7N9) virus.

scholarly journals Vaccination against Human Influenza A/H3N2 Virus Prevents the Induction of Heterosubtypic Immunity against Lethal Infection with Avian Influenza A/H5N1 Virus

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5538 ◽  
Author(s):  
Rogier Bodewes ◽  
Joost H. C. M. Kreijtz ◽  
Chantal Baas ◽  
Martina M. Geelhoed-Mieras ◽  
Gerrie de Mutsert ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza A ◽  
H5n1 Virus ◽  
H3n2 Virus ◽  
Human Influenza ◽  
Lethal Infection ◽  
Heterosubtypic Immunity
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