scholarly journals Investigation of Intrarenal Viral Infections in Kidney Transplant Recipients Unveils an Association between Parvovirus B19 and Chronic Allograft Injury

2009 ◽  
Vol 199 (3) ◽  
pp. 372-380 ◽  
Author(s):  
Luisa Barzon ◽  
Luisa Murer ◽  
Monia Pacenti ◽  
Maria Angela Biasolo ◽  
Manuela Della Vella ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Viral Infections ◽  
Parvovirus B19 ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Butyrate‐producing gut bacteria and viral infections in kidney transplant recipients: A pilot study

2019 ◽  
Vol 21 (6) ◽  
Author(s):  
John R. Lee ◽  
Jennifer Huang ◽  
Matthew Magruder ◽  
Lisa T. Zhang ◽  
Catherine Gong ◽  
...  
Keyword(s):  
Pilot Study ◽  
Kidney Transplant ◽  
Viral Infections ◽  
Gut Bacteria ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Common viral infections in kidney transplant recipients

2018 ◽  
Vol 37 (4) ◽  
pp. 323-337 ◽  
Author(s):  
Jakapat Vanichanan ◽  
Suwasin Udomkarnjananun ◽  
Yingyos Avihingsanon ◽  
Kamonwan Jutivorakool
Keyword(s):  
Kidney Transplant ◽  
Viral Infections ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

In Kidney Transplant Recipients With a Positive Virtual Crossmatch, High PRA was Associated With Lower Incidence of Viral Infections

2016 ◽  
Vol 100 (3) ◽  
pp. 655-661 ◽  
Author(s):  
Sandesh Parajuli ◽  
Brenda L. Muth ◽  
Jennifer A. Turk ◽  
Brad C. Astor ◽  
Maha Mohammed ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Lower Incidence ◽  
Viral Infections ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Epidemiology of parvovirus B19 and anemia among kidney transplant recipients: A meta-analysis

2020 ◽  
Vol 12 (3) ◽  
pp. 241
Author(s):  
Wisit Kaewput ◽  
Charat Thongprayoon ◽  
NadeenJ Khoury ◽  
Tarun Bathini ◽  
NarothamaReddy Aeddula ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Parvovirus B19 ◽  
Meta Analysis ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients

2019 ◽  
Vol 20 (3) ◽  
pp. 546 ◽  
Author(s):  
Dominika Deborska-Materkowska ◽  
Agnieszka Perkowska-Ptasinska ◽  
Anna Sadowska-Jakubowicz ◽  
Jolanta Gozdowska ◽  
Michał Ciszek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Viral Infections ◽  
Killer Cell ◽  
Human Leukocyte ◽  
Infectious Complications ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cmv Infection ◽  
Kir Genes

Infection with cytomegalovirus (CMV) remains a major problem in kidney transplant recipients, resulting in serious infectious complications and occasionally mortality. Accumulating evidence indicates that natural killer cell immunoglobulin-like receptors (KIRs) and their ligands affect the susceptibility to various diseases, including viral infections (e.g., CMV infection). We investigated whether KIR genes and their ligands affect the occurrence of CMV infection in a group of 138 kidney transplant recipients who were observed for 720 days posttransplantation. We typed the recipients for the presence of KIR genes (human leukocyte antigen C1 [HLA-C1], HLA-C2, HLA-A, HLA-B, and HLA-DR1) by polymerase chain reaction with sequence-specific primers. The multivariate analysis revealed that the lack of KIR2DS2 (p = 0.035), the presence of KIR2DL3 (p = 0.075), and the presence of KIR2DL2–HLA-C1 (p = 0.044) were risk factors for posttransplant CMV infection. We also found that a lower estimated glomerular filtration rate (p = 0.036), an earlier time of antiviral prophylaxis initiation (p = 0.025), lymphocytopenia (p = 0.012), and pretransplant serostatus (donor-positive/recipient-negative; p = 0.042) were independent risk factors for posttransplant CMV infection. In conclusion, our findings confirm that the KIR/HLA genotype plays a significant role in anti-CMV immunity and suggest the contribution of both environmental and genetic factors to the incidence of CMV infection after kidney transplantation.

scholarly journals Impact of Desensitization on Antiviral Immunity in HLA-Sensitized Kidney Transplant Recipients

2017 ◽  
Vol 2017 ◽  
pp. 1-24 ◽  
Author(s):  
Mieko Toyoda ◽  
Bong-Ha Shin ◽  
Shili Ge ◽  
James Mirocha ◽  
David Thomas ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Viral Infections ◽  
Nk Cell ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Mortality Factors ◽  
Lymphocyte Depletion ◽  
Increased Risk ◽  
Viral Infection Status ◽  
Ebv Viremia

Viral infections represent significant morbidity and mortality factors in kidney transplant recipients, with CMV, EBV, and BKV infections being most common. Desensitization (DES) with IVIg and rituximab with/without plasma exchange followed by kidney transplantation with alemtuzumab induction increased successful transplant rates in HLA-sensitized patients but may represent an increased risk for viral infections due to severe lymphocyte depletion. Here, we report on the posttransplant viral infection status in 372 DES versus 538 non-DES patients. CMV and EBV viremia were significantly lower in DES patients, while BKV viremia was similar. This trend was observed primarily in CMV sero(−), EBV sero(+), and sero(−) patients. No patient developed PTLD. The incidence of BKAN, allograft, and patient survival was similar in both groups. These viral infections were not associated with subsequent allograft rejection which occurred within 6 months after the infection.Conclusions.The IVIg + rituximab desensitization combined with alemtuzumab induction with triple immunosuppression maintenance does not increase the risk for CMV, EBV, and BKV infections. Possible factors include, in addition to posttransplant antiviral prophylaxis and PCR monitoring, presence of memory T cells and antibodies specific to CMV and likely EBV, NK cell-mediated ADCC despite lymphocyte depletion, elimination of EBV and CMV reservoirs by rituximab and alemtuzumab, and use of IVIg with antiviral properties.

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