scholarly journals Multidrug-Resistant Acinetobacter baumannii in New York City—10 Years Into the Epidemic

2009 ◽  
Vol 30 (2) ◽  
pp. 196-197 ◽  
Author(s):  
Daniel J. Morgan ◽  
Scott A. Weisenberg ◽  
Michael H. Augenbraun ◽  
David P. Calfee ◽  
Brian P. Currie ◽  
...  
Keyword(s):  
New York ◽  
New York City ◽  
Acinetobacter Baumannii ◽  
York City ◽  
Multidrug Resistant

scholarly journals Activity of Eravacycline against Enterobacteriaceae and Acinetobacter baumannii, Including Multidrug-Resistant Isolates, from New York City

2014 ◽  
Vol 59 (3) ◽  
pp. 1802-1805 ◽  
Author(s):  
Marie Abdallah ◽  
Olawole Olafisoye ◽  
Christopher Cortes ◽  
Carl Urban ◽  
David Landman ◽  
...  
Keyword(s):  
New York ◽  
New York City ◽  
Acinetobacter Baumannii ◽  
York City ◽  
Enterobacter Aerogenes ◽  
Enterobacter Cloacae ◽  
Multidrug Resistant ◽  
Gram Negative ◽  
Content Type

ABSTRACTEravacycline demonstratedin vitroactivity against a contemporary collection of more than 4,000 Gram-negative pathogens from New York City hospitals, with MIC50/MIC90values, respectively, forEscherichia coliof 0.12/0.5 μg/ml,Klebsiella pneumoniaeof 0.25/1 μg/ml,Enterobacter aerogenesof 0.25/1 μg/ml,Enterobacter cloacae0.5/1 μg/ml, andAcinetobacter baumanniiof 0.5/1 μg/ml. Activity was retained against multidrug-resistant isolates, including those expressing KPC and OXA carbapenemases. ForA. baumannii, eravacycline MICs correlated with increased expression of theadeBgene.

Genetic relatedness of multidrug-resistantAcinetobacter baumanniiendemic to New York City

2008 ◽  
Vol 137 (2) ◽  
pp. 174-180 ◽  
Author(s):  
D. LANDMAN ◽  
M. BUTNARIU ◽  
S. BRATU ◽  
J. QUALE
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Gel Electrophoresis ◽  
Genetic Relatedness ◽  
Multidrug Resistant ◽  
Pulsed Field Gel Electrophoresis ◽  
Resistant Strains ◽  
Further Development ◽  
Multilocus Sequencing

SUMMARYMultidrug-resistant isolates ofAcinetobacter baumanniifrom New York City generally belong to one of three ribotypes. To assess the accuracy of ribotyping, the relatedness of representative isolates was further assessed by rep-PCR, pulsed-field gel electrophoresis (PFGE), and DNA sequencing of five genes potentially associated with antimicrobial resistance (ampC,ompA,adeB,adeR, andabeM). The isolates fell into several major groups. The first group shared the same ribotype and had common mutations affecting OmpA, AdeR, and AbeM, but consisted of two subtypes with distinctive rep-PCR and PFGE patterns andampCmutations. The second and third groups shared common alterations in OmpA, AdeR, and AbeM, but had distinct ribotype, rep-PCR, and PFGE patterns. The resistant isolates were unrelated to the β-lactam susceptible isolates. Many of the resistant strains shared OmpA and AdeB patterns observed in several European clonal groups. Further development of a multilocus sequencing typing scheme will help determine if multidrug-resistant isolates from diverse geographic areas are indeed ancestrally related.

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