scholarly journals Down‐Regulation of Interleukin‐7 Receptor (CD127) in HIV Infection Is Associated with T Cell Activation and Is a Main Factor Influencing Restoration of CD4+Cells after Antiretroviral Therapy

2008 ◽  
Vol 198 (10) ◽  
pp. 1466-1473 ◽  
Author(s):  
José M. Benito ◽  
Mariola López ◽  
Sara Lozano ◽  
Juan González‐Lahoz ◽  
Vincent Soriano
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd4 Cells ◽  
Down Regulation ◽  
Interleukin 7 ◽  
Main Factor

scholarly journals Antiretroviral Therapy Initiated During Acute HIV Infection Fails to Prevent Persistent T-Cell Activation

2013 ◽  
Vol 62 (5) ◽  
pp. 505-508 ◽  
Author(s):  
Michael J. Vinikoor ◽  
Anna Cope ◽  
Cynthia L. Gay ◽  
Guido Ferrari ◽  
Kara S. McGee ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Cell Activation ◽  
Acute Hiv Infection ◽  
Acute Hiv

Highly active antiretroviral therapy during early HIV infection reverses T-cell activation and maturation abnormalities

AIDS ◽  
1998 ◽  
Vol 12 (16) ◽  
pp. 2115-2123 ◽  
Author(s):  
Leslie R. Bisset ◽  
Richard W. Cone ◽  
Werner Huber ◽  
Manuel Battegay ◽  
Pietro L. Vernazza ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Highly Active Antiretroviral Therapy ◽  
Cell Activation ◽  
Highly Active

scholarly journals Antiretroviral Therapy Initiated Within 6 Months of HIV Infection Is Associated With Lower T-Cell Activation and Smaller HIV Reservoir Size

2013 ◽  
Vol 208 (8) ◽  
pp. 1202-1211 ◽  
Author(s):  
Vivek Jain ◽  
Wendy Hartogensis ◽  
Peter Bacchetti ◽  
Peter W. Hunt ◽  
Hiroyu Hatano ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Cell Activation ◽  
Hiv Reservoir

scholarly journals Maintenance of Viral Suppression in Human Immunodeficiency Virus Controllers Despite Waning T-Cell Responses During Antiretroviral Therapy

2020 ◽  
Vol 222 (11) ◽  
pp. 1837-1842 ◽  
Author(s):  
Nikolaus Jilg ◽  
Pilar Garcia-Broncano ◽  
Michael Peluso ◽  
Florencia P Segal ◽  
Ronald J Bosch ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Activation ◽  
Cell Activation ◽  
T Cell Responses ◽  
Cell Responses ◽  
Immunodeficiency Virus ◽  
Undetectable Viremia ◽  
Hiv Controllers

Abstract AIDS Clinical Trials Group study A5308 found reduced T-cell activation and exhaustion in human immunodeficiency virus (HIV) controllers start antiretroviral therapy (ART). We further assessed HIV-specific T-cell responses and post-ART viral loads. Before ART, the 31% of participants with persistently undetectable viremia had more robust HIV-specific T-cell responses. During ART, significant decreases were observed in a broad range of T-cell responses. Eight controllers in A5308 and the Study of the Consequences of the Protease Inhibitor Era (SCOPE) cohort showed no viremia above the level of quantification in the first 12 weeks after ART discontinuation. ART significantly reduced HIV-specific T-cell responses in HIV controllers but did not adversely affect controller status after ART discontinuation.

scholarly journals Changes in Inflammation but Not in T-Cell Activation Precede Non-AIDS-Defining Events in a Case-Control Study of Patients on Long-term Antiretroviral Therapy

2017 ◽  
Vol 218 (2) ◽  
pp. 239-248 ◽  
Author(s):  
Konstantia Angelidou ◽  
Peter W Hunt ◽  
Alan L Landay ◽  
Cara C Wilson ◽  
Benigno Rodriguez ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Activation ◽  
Cell Activation ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Factors Associated With CD8+ T-Cell Activation in HIV-1–Infected Patients on Long-term Antiretroviral Therapy

2014 ◽  
Vol 67 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Lu Zheng ◽  
Babafemi Taiwo ◽  
Rajesh T. Gandhi ◽  
Peter W. Hunt ◽  
Ann C. Collier ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Factors Associated ◽  
Hiv 1

scholarly journals The impact of age on the prognostic capacity of CD8+ T-cell activation during suppressive antiretroviral therapy

AIDS ◽  
2013 ◽  
Vol 27 (13) ◽  
pp. 2101-2110 ◽  
Author(s):  
Judith J. Lok ◽  
Peter W. Hunt ◽  
Ann C. Collier ◽  
Constance A. Benson ◽  
Mallory D. Witt ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
The Impact
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