scholarly journals Low Risk of Tropical Spastic Paraparesis/Human T Lymphotropic Virus Type 1–Associated Myelopathy Development among Persons Aged >50 Years

2008 ◽  
Vol 47 (5) ◽  
pp. 728-729 ◽  
Author(s):  
Jorge Casseb ◽  
Augusto C. P. Oliveira
Keyword(s):  
Virus Type ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Low Risk ◽  
T Lymphotropic Virus

The Role of Human T-Lymphotropic Virus Type 1 (HTLV-1)-Infected Dendritic Cells in the Development of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

1999 ◽  
Vol 73 (6) ◽  
pp. 4575-4581 ◽  
Author(s):  
Masahiko Makino ◽  
Satoshi Shimokubo ◽  
Shin-Ichi Wakamatsu ◽  
Shuji Izumo ◽  
Masanori Baba
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Virus Type ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Normal Donor ◽  
Dependent Manner ◽  
T Lymphotropic Virus

ABSTRACT The development of human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is closely associated with the activation of T cells which are HTLV-1 specific but may cross-react with neural antigens (Ags). Immature dendritic cells (DCs), differentiated from normal donor monocytes by using recombinant granulocyte-macrophage colony-stimulating factor and recombinant interleukin-4, were pulsed with HTLV-1 in vitro. The pulsed DCs contained HTLV-1 proviral DNA and expressed HTLV-1 Gag Ag on their surface 6 days after infection. The DCs matured by lipopolysaccharides stimulated autologous CD4+ T cells and CD8+ T cells in a viral dose-dependent manner. However, the proliferation level of CD4+ T cells was five- to sixfold higher than that of CD8+ T cells. In contrast to virus-infected DCs, DCs pulsed with heat-inactivated virions activated only CD4+ T cells. To clarify the role of DCs in HAM/TSP development, monocytes from patients were cultured for 4 days in the presence of the cytokines. The expression of CD86 Ag on DCs was higher and that of CD1a Ag was more down-regulated than in DCs generated from normal monocytes. DCs from two of five patients expressed HTLV-1 Gag Ag. Furthermore, both CD4+ and CD8+ T cells from the patients were greatly stimulated by contact with autologous DCs pulsed with inactivated viral Ag as well as HTLV-1-infected DCs. These results suggest that DCs are susceptible to HTLV-1 infection and that their cognate interaction with T cells may contribute to the development of HAM/TSP.

Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: The First Case Report in Southeast Asia

2017 ◽  
Vol 33 (7) ◽  
pp. 629-631
Author(s):  
Sekh Thanprasertsuk ◽  
Suwapan Pleumkanitkul ◽  
Supaporn Wacharapluesadee ◽  
Teerada Ponpinit ◽  
Thiravat Hemachudha ◽  
...  
Keyword(s):  
Case Report ◽  
Southeast Asia ◽  
Virus Type ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
T Lymphotropic Virus ◽  
First Case

scholarly journals Human T-lymphotropic virus type 1–associated myelopathy/tropical spastic paraparesis: Viral load and muscle tone are correlated

2006 ◽  
Vol 12 (6) ◽  
pp. 466-471
Author(s):  
J R Zunt ◽  
S M Montano ◽  
I Beck ◽  
J OV Alarcón ◽  
L M Frenkel ◽  
...  
Keyword(s):  
Viral Load ◽  
Virus Type ◽  
Muscle Tone ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
T Lymphotropic Virus

scholarly journals Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis

2009 ◽  
Vol 156 (3) ◽  
pp. 455-462 ◽  
Author(s):  
M. C. F. Nascimento ◽  
J. Primo ◽  
A. Bittencourt ◽  
I. Siqueira ◽  
M. de Fátima Oliveira ◽  
...  
Keyword(s):  
Virus Type ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
T Lymphotropic Virus
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