scholarly journals Dengue in Vietnamese Infants—Results of Infection‐Enhancement Assays Correlate with Age‐Related Disease Epidemiology, and Cellular Immune Responses Correlate with Disease Severity

2008 ◽  
Vol 198 (4) ◽  
pp. 516-524 ◽  
Author(s):  
Tran Nguyen Bich Chau ◽  
Nguyen Than Ha Quyen ◽  
Tran Thi Thuy ◽  
Nguyen Minh Tuan ◽  
Dang Minh Hoang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Disease Severity ◽  
Disease Epidemiology ◽  
Cellular Immune Responses ◽  
Related Disease ◽  
Age Related ◽  
Cellular Immune

scholarly journals Aging dampens the intestinal innate immune response during Clostridioides difficile infection and is associated with altered intestinal eosinophil mobilization

2020 ◽  
Author(s):  
Lisa Abernathy-Close ◽  
Michael G. Dieterle ◽  
Kimberly C. Vendrov ◽  
Ingrid L. Bergin ◽  
Vincent B. Young
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Disease Severity ◽  
Advanced Age ◽  
Simultaneous Increase ◽  
Aged Mice ◽  
Age Related ◽  
Cellular Immune ◽  
The Impact ◽  
Young Mice

ABSTRACTClostridioides (formerly Clostridium) difficile is the most common cause of hospital-acquired infection, and advanced age is a risk factor for C. difficile infection. Disruption of the intestinal microbiota and immune responses contribute to host susceptibility and severity of C. difficile infection. However, the impact of aging on the cellular immune response associated with C. difficile infection in the setting of advanced age remains to be well described. This study explores the effect of age on cellular immune responses in C. difficile infection as well as disease severity. Young adult mice (2-3 months old) and aged mice (22-28 months old) were rendered susceptible to C. difficile infection with cefoperazone and then infected with C. difficile strains of varying disease-causing potential. Aged mice infected with C. difficile develop more severe clinical disease, compared to young mice. Tissue-specific CD45+ immune cell responses occurred at the time of peak disease severity in the cecum and colon of all mice infected with a high-virulence strain of C. difficile; however, significant deficits in intestinal neutrophils and eosinophils were detected in aged mice. Interestingly, while C. difficile infection in young mice was associated with a robust increase in cecal and colonic eosinophils, there was a complete lack of an intestinal eosinophil response in aged counterparts accompanied by a simultaneous increase in blood eosinophils with severe disease. These findings demonstrate that age-related alterations in immune responses are associated with significantly worse C. difficile infection and support a key role for intestinal eosinophils in mitigating C. difficile-mediated disease severity.

scholarly journals Viral Load, Clinical Disease Severity and Cellular Immune Responses in Primary Varicella Zoster Virus Infection in Sri Lanka

PLoS ONE ◽  
2008 ◽  
Vol 3 (11) ◽  
pp. e3789 ◽  
Author(s):  
Gathsaurie Neelika Malavige ◽  
Louise Jones ◽  
S. D. Kamaladasa ◽  
A. Wijewickrama ◽  
S. L. Seneviratne ◽  
...  
Keyword(s):  
Viral Load ◽  
Sri Lanka ◽  
Virus Infection ◽  
Immune Responses ◽  
Varicella Zoster Virus ◽  
Disease Severity ◽  
Varicella Zoster Virus Infection ◽  
Varicella Zoster ◽  
Cellular Immune Responses ◽  
Cellular Immune

scholarly journals Age-related differences in humoral and cellular immune responses after primary immunisation: indications for stratified vaccination schedules

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Angelika Wagner ◽  
Erika Garner-Spitzer ◽  
Joanna Jasinska ◽  
Herwig Kollaritsch ◽  
Karin Stiasny ◽  
...  
Keyword(s):  
Immune Responses ◽  
Cellular Immune Responses ◽  
Primary Immunisation ◽  
Age Related ◽  
Cellular Immune

scholarly journals Local immune response to respiratory syncytial virus infection is diminished in senescence-accelerated mice

2007 ◽  
Vol 88 (9) ◽  
pp. 2552-2558 ◽  
Author(s):  
Beixing Liu ◽  
Yoshinobu Kimura
Keyword(s):  
Respiratory Syncytial Virus ◽  
T Lymphocytes ◽  
Immune Responses ◽  
Aged Mouse ◽  
Virus Growth ◽  
Cellular Immune Responses ◽  
Age Related ◽  
Rsv Infection ◽  
Syncytial Virus ◽  
Cellular Immune

The effect of ageing on the local defence system against respiratory syncytial virus (RSV) infection was investigated using an aged mouse model of the senescence-accelerated mouse (SAM) strain P1. Following intranasal infection with RSV, SAM-P1 mice showed a marked loss in weight, with elevated virus growth in the lungs and prolonged virus shedding. The increased susceptibility to RSV infection was associated mainly with diminished cellular immunity by local virus-specific cytotoxic T lymphocytes and natural killer cells. The deficiency in cellular immune responses was due to a lack of clonal expansion of CD4+ and CD8+ T lymphocytes, together with an imbalance of T-helper type 1 (Th1)/Th2 cytokine production in the respiratory tract, including the lungs. Furthermore, the production of virus-specific local IgA antibody was restrained. Prolonged virus loading in the lungs of SAM-P1 mice caused a massive infiltration of CD16+/32+ inflammatory cells, which was one factor responsible for severe pneumonia. The adoptive transfer of immune-competent spleen cells achieved an appreciable protection for SAM-P1 mice against RSV challenge infection. These results suggested that age-related immune dysfunction, especially defects in cellular immune responses, accounts for the increased morbidity and mortality in RSV infection of the elderly.

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