scholarly journals CD4+T Cell Depletion in an Untreated HIV Type 1–Infected Human Leukocyte Antigen–B*5801–Positive Patient with an Undetectable Viral Load

2008 ◽  
Vol 46 (8) ◽  
pp. e78-e82 ◽  
Author(s):  
Adriana Andrade ◽  
Justin R. Bailey ◽  
Jie Xu ◽  
Frances H. Philp ◽  
Thomas C. Quinn ◽  
...  
Keyword(s):  
Viral Load ◽  
T Cell ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Undetectable Viral Load ◽  
Cd4 T Cell ◽  
Leukocyte Antigen ◽  
Antigen B ◽  
Hiv Type 1

scholarly journals Juxtaposition of Coeliac Disease and Type 1 Diabetes; the Role of Shared Non-Human Leukocyte Antigen Loci

2018 ◽  
Vol 3 (1) ◽  
pp. 1-8
Author(s):  
Iraj Shahramian ◽  
Hossein Shahdadi ◽  
Ali Bazi ◽  
Nosratollah Masinaeinejad ◽  
Mojtaba Delaramnasab
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Human Leukocyte Antigen ◽  
Coeliac Disease ◽  
Adaptor Protein ◽  
Human Leukocyte ◽  
Substantial Impact ◽  
Leukocyte Antigen

Although extensive studies have been performed to explore the role of various alleles within the human leukocyte antigen (HLA) in susceptibility to coeliac disease (CD) and type 1 diabetes (T1D), less attention has been dedicated to the role of shred non-HLA loci. In present report, we have provided a review on the role of genetic variants in seven shared non-HLA loci in determination the risk of either CD or T1D. The literature search was done on the Web of Knowledge, PubMed, and Scopus databases using keywords of polymorphism, coeliac disease, and type 1 diabetes. The literature published within 2000-2017 were recruited. Seven discussed shared loci between CD and T1D were those resided within cytotoxic T-lymphocyte associated protein 4 (CTL4), regulator of G protein signaling (RGS1), SH2B adaptor protein (SH2B3), T cell activation Rho GTPase activating protein (TAGAP), interleukin 18 receptor accessory protein (IL18RAP), protein tyrosine phosphatase, non-receptor type (PTPN2), and C-C motif chemokine receptor (CCR5). Interaction between polymorphisms of these genes seems to exert a substantial impact on determination the risk of CD and T1D in context of each other. Polymorphisms residing in these loci can exert synergistic or opposing effects toward either protection or predisposition to CD and T1D. The majority of these polymorphisms affect the function of cytokine signaling or T cell activating pathways. The net outcome deems to be delineated by a complex interaction between these adaptor arms, as well as the modulatory effects of other components of immune system, in particular HLA alleles.

Early Viral Load and CD4+T Cell Count, But Not Percentage of CCR5+or CXCR4+CD4+T Cells, Are Associated with R5-to-X4 HIV Type 1 Virus Evolution

2003 ◽  
Vol 19 (5) ◽  
pp. 389-398 ◽  
Author(s):  
Ronald P. van Rij ◽  
Mette D. Hazenberg ◽  
Birgit H.B. van Benthem ◽  
Sigrid A. Otto ◽  
Maria Prins ◽  
...  
Keyword(s):  
T Cells ◽  
Viral Load ◽  
T Cell ◽  
Cell Count ◽  
Cd4 T Cells ◽  
Virus Evolution ◽  
Cd4 T Cell ◽  
Hiv Type 1 ◽  
Cd4 T Cell Count

scholarly journals Human leukocyte antigen (HLA) class I frequencies in human T-cell lymphotropic virus type 1 (HTLV-1)-infected patients from Salvador-Brazil

Retrovirology ◽  
2011 ◽  
Vol 8 (Suppl 1) ◽  
pp. A121
Author(s):  
Viviana N Olavarria ◽  
Maria F Grassi ◽  
Ramon Kruschewsky ◽  
Xiao-Jiang Gao ◽  
Alline Nascimento ◽  
...  
Keyword(s):  
T Cell ◽  
Human Leukocyte Antigen ◽  
Virus Type ◽  
Human Leukocyte ◽  
Hla Class I ◽  
Class I ◽  
Leukocyte Antigen ◽  
Human T Cell

CD8+CD38+T Cells But Not HIV Type 1 RNA Viral Load Predict CD4+T Cell Loss in a Predominantly Minority Female HIV+Adolescent Population

2004 ◽  
Vol 20 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Craig M. Wilson ◽  
Jonas H. Ellenberg ◽  
Steven D. Douglas ◽  
Anna-Barbara Moscicki ◽  
Christie A. Holland ◽  
...  
Keyword(s):  
T Cells ◽  
Viral Load ◽  
T Cell ◽  
Cell Loss ◽  
Cd4 T Cell ◽  
Adolescent Population ◽  
Predominantly Minority ◽  
Hiv Type 1
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