scholarly journals Efavirenz‐Based Regimens in Treatment‐Naive Patients with a Range of Pretreatment HIV‐1 RNA Levels and CD4 Cell Counts

2008 ◽  
Vol 197 (7) ◽  
pp. 1006-1010 ◽  
Author(s):  
Heather J. Ribaudo ◽  
Daniel R. Kuritzkes ◽  
Christina M. Lalama ◽  
Jeffrey T. Schouten ◽  
Bruce R. Schackman ◽  
...  
2009 ◽  
Vol 52 (3) ◽  
pp. 422-426 ◽  
Author(s):  
Valérie Potard ◽  
Laurence Weiss ◽  
Franck Lamontagne ◽  
Elisabeth Rouveix ◽  
Geneviève Beck-Wirth ◽  
...  

AIDS ◽  
2007 ◽  
Vol 21 (2) ◽  
pp. 169-178 ◽  
Author(s):  
Lidia Ruiz ◽  
Roger Paredes ◽  
Guadalupe Gómez ◽  
Joan Romeu ◽  
Pere Domingo ◽  
...  

AIDS ◽  
2000 ◽  
Vol 14 (9) ◽  
pp. 1147-1153 ◽  
Author(s):  
Eoin P. G. Coakley ◽  
Matthew H. Samore ◽  
Jacqueline M. Gillis ◽  
Michael D. Hughes ◽  
Scott M. Hammer

AIDS ◽  
2013 ◽  
Vol 27 (15) ◽  
pp. 2441-2450 ◽  
Author(s):  
Dana N. Raugi ◽  
Geoffrey S. Gottlieb ◽  
Papa S. Sow ◽  
Macoumba Toure ◽  
Fatima Sall ◽  
...  
Keyword(s):  
Cd4 Cell ◽  

2021 ◽  
Vol 31 (4) ◽  
pp. 43-50
Author(s):  
Tran Thi Minh Tam ◽  
Nguyen Thuy Linh ◽  
Phan Ha My ◽  
Nguyen Thi Lan Anh

Human Leukocyte Antigen (HLA) class I plays a regulatory role in cellular immune response to HIV-1 infection. The role of HLA alleles in HIV progression via viral load and CD4 cell count is well known. HLA class I is polymorphic and distributed differently by nation. This descriptive cross-sectional study was performed on 303 HIV-1 infected patients in 2014 - 2016, with aims to (i) characterize HLA class I genotype with 4-digit nomenclature and (ii) identify specifc alleles in correlate with CD4 cell counts and HIV viral load. 117 allele genotypes have been identifed, including 28 HLA-A alleles, 54 HLA-B alleles and 35 HLA-C alleles. The results showed that the most prevalent alleles in the population include A*11:01 (30.7%), B*15:02 (15.2%) and C*08:01 (17.1%). The frequency of haplotype created from these alleles is 8.4%. A*02:03, B*46:01 related to gender and ethnicity respectively. In conclusion, the study provided detailed pattern of HLA class I expression in a study population of HIV-1 infected patients and reported for the frst time the associated B*51:01, C*14:02 alleles associated to an increase in CD4 cell counts.


2011 ◽  
Vol 57 (5) ◽  
pp. 387-395 ◽  
Author(s):  
Hemant Kulkarni ◽  
Jason F Okulicz ◽  
Greg Grandits ◽  
Nancy F Crum-Cianflone ◽  
Michael L Landrum ◽  
...  

1996 ◽  
Vol 40 (11) ◽  
pp. 2664-2668 ◽  
Author(s):  
A M Been-Tiktak ◽  
I Williams ◽  
H M Vrehen ◽  
J Richens ◽  
D Aldam ◽  
...  

Atevirdine is a nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1). In this study we investigated the effect of atevirdine in asymptomatic antiretroviral naive HIV-infected patients with CD4+ cell counts of between 200 and 750 cells per mm3. Patients were randomized to receive 600 mg of atevirdine (n = 15) or a placebo (n = 15) three times a day for 12 weeks. There was no statistically significant effect of atevirdine on viral loads (HIV p24 antigen and HIV-1 RNA levels by PCR) or CD4+ cell counts. The data do not support the use of atevirdine as a monotherapy in the treatment of HIV-infected patients.


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