scholarly journals Long-Term Effectiveness of Highly Active Antiretroviral Therapy on the Survival of Children and Adolescents with HIV Infection: A 10-Year Follow-Up Study

2008 ◽  
Vol 46 (4) ◽  
pp. 507-515 ◽  
Author(s):  
K. Patel ◽  
M. A. Herna n ◽  
P. L. Williams ◽  
J. D. Seeger ◽  
K. McIntosh ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Children And Adolescents ◽  
Highly Active Antiretroviral Therapy ◽  
Follow Up Study ◽  
Highly Active

scholarly journals Long-Term Effects of Highly Active Antiretroviral Therapy in Pretreated, Vertically HIV Type 1-Infected Children: 6 Years of Follow-Up

2006 ◽  
Vol 42 (6) ◽  
pp. 862-869 ◽  
Author(s):  
S. Resino ◽  
R. Resino ◽  
D. Micheloud ◽  
D. Gurbindo-Gutierrez ◽  
J. A. Leon ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Long Term Effects ◽  
Highly Active ◽  
Hiv Type 1

scholarly journals Nutritional assessment and lipid profile in HIV-infected children and adolescents treated with highly active antiretroviral therapy

2011 ◽  
Vol 44 (3) ◽  
pp. 274-281 ◽  
Author(s):  
Marina Hjertquist Tremeschin ◽  
Daniela Saes Sartorelli ◽  
Maria Célia Cervi ◽  
Bento Vidal de Moura Negrini ◽  
Roberta Garcia Salomão ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Protease Inhibitor ◽  
Children And Adolescents ◽  
Highly Active Antiretroviral Therapy ◽  
Serum Levels ◽  
Hiv Positive ◽  
Control Group ◽  
Highly Active ◽  
Healthy Control

INTRODUCTION: HIV-infected children and adolescents treated with highly active antiretroviral therapy (HAART) regimens that include a protease inhibitor (PI) can show significant improvements in clinical outcomes, nutritional status and quality of life. The study aimed to report nutritional and metabolic alterations for pediatric patients continuously exposed to HAART and for healthy controls for up to 1 year. METHODS: Clinical, anthropometric, lipid profile and food intake data were collected prospectively over approximately 12-months for each patient. RESULTS: Fifty-one individuals were studied, of these, 16 were healthy. After 12 months follow-up, HIV-positive individuals remained below the healthy control group parameters. No change was observed concerning food intake. Triglyceride serum levels were higher in patients using protease inhibitor at the onset of the study [PI groups: 114 (43 - 336), and 136 (63 - 271) versus control group: 54.5 (20 - 162); p = 0.003], but after twelve months follow-up, only the group using protease inhibitor for up to two months presented higher values [140 (73 - 273) versus 67.5 (33 - 117); p = 0.004]. HDL-cholesterol was lower in HIV-positive individuals [HIV-positive groups: 36 (27 - 58) and 36 (23 - 43); control 49.5 (34 - 69); p = 0.004]. CONCLUSIONS: HIV-infected children and adolescents treated with highly active antiretroviral therapy showed compromised nutritional parameters compared to a paired healthy control group. Individuals using protease inhibitor presented worse triglyceride serum levels compared to their healthy counterparts.

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