scholarly journals Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas

2008 ◽  
Vol 197 (s1) ◽  
pp. S19-S24 ◽  
Author(s):  
Eileen Thacker ◽  
Bruce Janke
Keyword(s):  
Influenza Virus ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Zoonotic Potential ◽  
Vaccination Strategies

Evaluation of the zoonotic potential of a novel reassortant H1N2 swine influenza virus with gene constellation derived from multiple viral sources

2015 ◽  
Vol 34 ◽  
pp. 378-393 ◽  
Author(s):  
Jee Hoon Lee ◽  
Philippe Noriel Q. Pascua ◽  
Arun G. Decano ◽  
Se Mi Kim ◽  
Su-Jin Park ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Zoonotic Potential

scholarly journals Epidemic Status of Swine Influenza Virus in China

2013 ◽  
Vol 54 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Weili Kong ◽  
Jiahui Ye ◽  
Shangsong Guan ◽  
Jinhua Liu ◽  
Juan Pu
Keyword(s):  
Influenza Virus ◽  
Swine Influenza Virus ◽  
Swine Influenza

scholarly journals Isolation of a Novel Swine Influenza Virus from Oklahoma in 2011 Which Is Distantly Related to Human Influenza C Viruses

2013 ◽  
Vol 9 (2) ◽  
pp. e1003176 ◽  
Author(s):  
Ben M. Hause ◽  
Mariette Ducatez ◽  
Emily A. Collin ◽  
Zhiguang Ran ◽  
Runxia Liu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Human Influenza

scholarly journals Designing Inhibitors of M2 Proton Channel against H1N1 Swine Influenza Virus

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9388 ◽  
Author(s):  
Qi-Shi Du ◽  
Ri-Bo Huang ◽  
Shu-Qing Wang ◽  
Kuo-Chen Chou
Keyword(s):  
Influenza Virus ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Proton Channel ◽  
M2 Proton Channel

scholarly journals Bat influenza vectored NS1-truncated live vaccine protects pigs against heterologous virus challenge

2020 ◽  
Author(s):  
Jinhwa Lee ◽  
Yonghai Li ◽  
Yuhao Li ◽  
A. Giselle Cino-Ozuna ◽  
Michael Duff ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Influenza A ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Live Vaccine ◽  
H3n2 Virus ◽  
Swine Industry ◽  
Vaccine Candidates ◽  
Virus Challenge ◽  
Significant Difference

AbstractSwine influenza is an important disease for the swine industry. Currently used whole inactivated virus (WIV) vaccines can induce vaccine-associated enhanced respiratory disease (VAERD) in pigs when the vaccine strains mismatch with the infected viruses. Live attenuated influenza virus vaccine (LAIV) is effective to protect pigs against homologous and heterologous swine influenza virus infections without inducing VAERD, but has safety concerns due to potential reassortment with circulating viruses. Herein, we used a chimeric bat influenza Bat09:mH3mN2 virus, which contains both surface HA and NA gene open reading frames of the A/swine/Texas/4199-2/1998 (H3N2) and six internal genes from the novel bat H17N10 virus, to develop modified live-attenuated viruses (MLVs) as vaccine candidates which cannot reassort with canonical influenza A viruses by co-infection. Two attenuated MLV vaccine candidates including the virus that expresses a truncated NS1 (Bat09:mH3mN2-NS1-128, MLV1) or expresses both a truncated NS1 and the swine IL-18 (Bat09:mH3mN2-NS1-128-IL-18, MLV2) were generated and evaluated in pigs against a heterologous H3N2 virus using the WIV vaccineb as a control. Compared to the WIV vaccine, both MLV vaccines were able to reduce lesions and virus replication in lungs and limit nasal virus shedding without VAERD, also induced significantly higher levels of mucosal IgA response in lungs and significantly increased numbers of antigen-specific IFN-γ secreting cells against the challenge virus. However, no significant difference was observed in efficacy between the MLV1 and MLV2. These results indicate that bat influenza vectored MLV vaccines can be used as a safe live vaccine to prevent swine influenza.

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