scholarly journals Specific Polymorphisms in Hepatitis C Virus Genotype 3 Core Protein Associated with Intracellular Lipid Accumulation

2008 ◽  
Vol 197 (2) ◽  
pp. 283-291 ◽  
Author(s):  
Ravi Jhaveri ◽  
John McHutchison ◽  
Keyur Patel ◽  
Guan Qiang ◽  
Anna Mae Diehl
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lipid Accumulation ◽  
Core Protein ◽  
Genotype 3 ◽  
Virus Genotype ◽  
Intracellular Lipid ◽  
Intracellular Lipid Accumulation

scholarly journals microRNA-99a Restricts Replication of Hepatitis C Virus by Targeting mTOR and De Novo Lipogenesis

Viruses ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 696 ◽  
Author(s):  
Eun Byul Lee ◽  
Pil Soo Sung ◽  
Jung-Hee Kim ◽  
Dong Jun Park ◽  
Wonhee Hur ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lipid Accumulation ◽  
De Novo ◽  
Regulatory Element ◽  
Mammalian Target Of Rapamycin ◽  
De Novo Lipogenesis ◽  
Hcv Rna ◽  
Intracellular Lipid ◽  
Intracellular Lipid Accumulation

In this study, we investigated the role of microRNA-99a (miR-99a) in hepatitis C virus (HCV) replication and lipogenesis in hepatocytes. Cell-culture-derived HCV (HCVcc) infection caused down-regulation of miR-99a in Huh-7 cells, and the relative levels of miR-99a were significantly lower in the sera of the HCV-infected patients than in those of healthy controls. Transfection of miR-99a-5p mimics resulted in a decrease in the intracellular and secreted HCV RNA levels. It also caused a decreased mammalian target of rapamycin (mTOR) protein level and phosphorylation of its downstream targets in HCV-replicating cells. Sterol regulatory element binding protein (SREBP)-1c expression and intracellular lipid accumulation decreased when either miR-99a-5p mimics or si-mTOR was transfected in oleic acid-treated Huh-7 cells. Overexpression of mTOR rescued HCV RNA replication and lipid droplet accumulation in miR-99a-5p mimics-transfected HCV replicon cells. Our data demonstrated that miR-99a ameliorates intracellular lipid accumulation by regulating mTOR/SREBP-1c and causes inefficient replication and packaging of intracellular HCV.

Hepatitis C virus genotype 3 was associated with the development of hepatocellular carcinoma in Korea

2019 ◽  
Vol 26 (4) ◽  
pp. 459-465 ◽  
Author(s):  
Sang Soo Lee ◽  
Cha Young Kim ◽  
Bo Ra Kim ◽  
Ra Ri Cha ◽  
Wan Soo Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 3 ◽  
Virus Genotype

scholarly journals Morphological changes in intracellular lipid droplets induced by different hepatitis C virus genotype core sequences and relationship with steatosis

Hepatology ◽  
2008 ◽  
Vol 48 (1) ◽  
pp. 16-27 ◽  
Author(s):  
Aurélie Piodi ◽  
Philippe Chouteau ◽  
Hervé Lerat ◽  
Christophe Hézode ◽  
Jean‐Michel Pawlotsky
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lipid Droplets ◽  
Morphological Changes ◽  
Virus Genotype ◽  
Intracellular Lipid

scholarly journals Hepatitis C virus genotype 3 and the risk of severe liver disease in a large population of drug users in France

2010 ◽  
Vol 82 (10) ◽  
pp. 1647-1654 ◽  
Author(s):  
Christine Larsen ◽  
Vanina Bousquet ◽  
Elisabeth Delarocque-Astagneau ◽  
Corinne Pioche ◽  
Françoise Roudot-Thoraval
Keyword(s):  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Drug Users ◽  
Large Population ◽  
Genotype 3 ◽  
Severe Liver ◽  
Virus Genotype ◽  
Severe Liver Disease
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