Bloodborne Pathogen Exposure Risk Among Surgeons in Sub-Saharan Africa

2007 ◽  
Vol 28 (12) ◽  
pp. 1334-1336 ◽  
Author(s):  
Elayne Kornblatt Phillips ◽  
Alex Owusu-Ofori ◽  
Janine Jagger
Keyword(s):  
Body Fluid ◽  
Sub Saharan Africa ◽  
Hepatitis B Vaccination ◽  
Postexposure Prophylaxis ◽  
Exposure Risk ◽  
Pan African ◽  
Immunodeficiency Virus ◽  
Bloodborne Pathogen ◽  
Sub Saharan ◽  
Pathogen Exposure

To document the frequency and circumstances of bloodborne pathogen exposures among surgeons in sub-Saharan Africa, we surveyed surgeons attending the 2006 Pan-African Association of Surgeons conference. During the previous year, surgeons sustained a mean of 3.1 percutaneous injuries, which were typically caused by suture needles. They sustained a mean of 4.1 exposures to blood and body fluid, predominantly from blood splashes to the eyes. Fewer than half of the respondents reported completion of hepatitis B vaccination, and postexposure prophylaxis for human immunodeficiency virus was widely available. Surgeons reported using hands-free passing and blunt suture needles. Non-fluid-resistant cotton gowns and masks were the barrier garments worn most frequently.

scholarly journals Development of an Intervention to Increase Occupational Postexposure Prophylaxis in Sub-Saharan Africa

2016 ◽  
Vol 27 (5) ◽  
pp. 727-730 ◽  
Author(s):  
Cari Courtenay-Quirk ◽  
Dejana Selenic ◽  
Maria Lahuerta ◽  
Getachew Kassa ◽  
Marita Murrman ◽  
...  
Keyword(s):  
Sub Saharan Africa ◽  
Postexposure Prophylaxis ◽  
Sub Saharan

scholarly journals Methylome-wide analysis reveals epigenetic marks associated with resistance to tuberculosis in HIV-infected individuals from East Africa

2020 ◽  
Author(s):  
Catherine Stein ◽  
Penelope Bencheck ◽  
Jacquelaine Bartlett ◽  
Robert P Igo ◽  
Rafal S Sobota ◽  
...  
Keyword(s):  
Genome Wide Association Study ◽  
Sub Saharan Africa ◽  
Chromosome 1 ◽  
Chromosome 2 ◽  
Chromosome 5 ◽  
Epigenetic Marks ◽  
Genome Wide ◽  
A Genome ◽  
Immunodeficiency Virus ◽  
Sub Saharan

Background: Tuberculosis (TB) is the most deadly infectious disease globally and highly prevalent in the developing world, especially sub-Saharan Africa. Even though a third of humans are exposed to Myocbacterium tuberculosis (Mtb), most infected immunocompetent individuals do not develop active TB. In contrast, for individuals infected with both TB and the human immunodeficiency virus (HIV), the risk of active disease is 10% or more per year. Previously, we identified in a genome-wide association study a region on chromosome 5 that was associated with resistance to TB. This region included epigenetic marks that could influence gene regulation so we hypothesized that HIV-infected individuals exposed to Mtb, who remain disease free, carry epigenetic changes that strongly protect them from active TB. To test this hypothesis, we conducted a methylome-wide study in HIV-infected, TB-exposed cohorts from Uganda and Tanzania. Results: In 221 HIV-infected adults from Uganda and Tanzania, we identified 3 regions of interest that included markers that were differentially methylated between TB cases and LTBI controls, that also included methylation QTLs and associated SNPs: chromosome 1 (RNF220, p=4x10-5), chromosome 2 (between COPS8 and COL6A3 genes, p=2.7x10-5), and chromosome 5 (CEP72, p=1.3x10-5). These methylation results colocalized with associated SNPs, methylation QTLs, and methylation x SNP interaction effects. These markers were in regions with regulatory markers for cells involved in TB immunity and/or lung. Conclusion: Epigenetic regulation is a potential biologic factor underlying resistance to TB in immunocompromised individuals that can act in conjunction with genetic variants.

scholarly journals The recent evolution of the HIV rates in Sub-Saharan Africa: Do differences still persist?

2019 ◽  
Author(s):  
antonio montañés bernal ◽  
Cristina Martínez
Keyword(s):  
Null Hypothesis ◽  
Incidence Rates ◽  
Sub Saharan Africa ◽  
Female Education ◽  
Prevalence Rates ◽  
African Countries ◽  
Total Incidence ◽  
Immunodeficiency Virus ◽  
Patterns Of Behavior ◽  
Sub Saharan

Abstract Background This paper studies the evolution of the human immunodeficiency virus (HIV) prevalence and incidence rates in Sub-Saharan African countries, paying special attention to the possible presence of a unique pattern of behavior of these variables across the mentioned countries during the 1990-2016 period. Methods We employ time series methods designed to analyze the hypothesis of convergence. We apply these tests to prevalence and incidence rates of the Sub-Saharan African countries for the 1990-2016 period. Results We cannot reject the null hypothesis of convergence for male prevalence rates and total incidence rates. By contrast, we can observe divergence in female prevalence rates, Conclusion The evolution of the male prevalence rates and incidence rates is quite similar for the Sub-Saharan countries. But, we can still find different patterns of behavior for female prevalence rates. Therefore, the recent HIV-oriented policies have not been able to control its transmission yet. We can also appreciate that some socioeconomic variables play a crucial role to explain the different behaviors of female prevalence rates, especially the level of female education. So, focusing on this variable is crucial to control this pandemia.

scholarly journals A Randomized Switch From Nevirapine-Based Antiretroviral Therapy to Single Tablet Rilpivirine/Emtricitabine/Tenofovir Disoproxil Fumarate in Virologically Suppressed Human Immunodeficiency Virus-1-Infected Rwandans

2016 ◽  
Vol 3 (3) ◽  
Author(s):  
Sean E. Collins ◽  
Philip M. Grant ◽  
Francois Uwinkindi ◽  
Annie Talbot ◽  
Eric Seruyange ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Tenofovir Disoproxil Fumarate ◽  
Sub Saharan Africa ◽  
Current Therapy ◽  
Virologic Suppression ◽  
Open Label ◽  
Immunodeficiency Virus ◽  
Sub Saharan ◽  
Hiv 1

Abstract Background.  Many human immunodeficiency virus (HIV)-infected patients remain on nevirapine-based antiretroviral therapy (ART) despite safety and efficacy concerns. Switching to a rilpivirine-based regimen is an alternative, but there is little experience with rilpivirine in sub-Saharan Africa where induction of rilpivirine metabolism by nevirapine, HIV subtype, and dietary differences could potentially impact efficacy. Methods.  We conducted an open-label noninferiority study of virologically suppressed (HIV-1 ribonucleic acid [RNA] < 50 copies/mL) HIV-1-infected Rwandan adults taking nevirapine plus 2 nucleos(t)ide reverse-transcriptase inhibitors. One hundred fifty participants were randomized 2:1 to switch to coformulated rilpivirine-emtricitabine-tenofovir disoproxil fumarate (referenced as the Switch Arm) or continue current therapy. The primary efficacy endpoint was HIV-1 RNA < 200 copies/mL at week 24 assessed by the US Food and Drug Administration Snapshot algorithm with a noninferiority margin of 12%. Results.  Between April and September 2014, 184 patients were screened, and 150 patients were enrolled; 99 patients switched to rilpivirine-emtricitabine-tenofovir, and 51 patients continued their nevirapine-based ART. The mean age was 42 years and 43% of participants were women. At week 24, virologic suppression (HIV-1 RNA level <200 copies/mL) was maintained in 93% and 92% in the Switch Arm versus the continuation arm, respectively. The Switch Arm was noninferior to continued nevirapine-based ART (efficacy difference 0.8%; 95% confidence interval, −7.5% to +12.0%). Both regimens were generally safe and well tolerated, although 2 deaths, neither attributed to study medications, occurred in participants in the Switch Arm. Conclusions.  A switch from nevirapine-based ART to rilpivirine-emtricitabine-tenofovir disoproxil fumarate had similar virologic efficacy to continued nevirapine-based ART after 24 weeks with few adverse events.

Introduction

ESC CardioMed ◽  
2018 ◽  
pp. 1185-1186
Author(s):  
Nombulelo P. Magula ◽  
Akira Singh
Keyword(s):  
Black Women ◽  
Hiv Infection ◽  
The United States ◽  
Sub Saharan Africa ◽  
Middle Income ◽  
High Burden ◽  
Immunodeficiency Virus ◽  
Widespread Availability ◽  
Sub Saharan ◽  
Young Black Women

Life expectancy has increased significantly with the widespread availability of antiretroviral therapy. Despite this, new human immunodeficiency virus (HIV) infection rates in low- to middle-income, high-burden countries remain a cause for concern. The greatest impact of infection remains in sub-Saharan Africa, among young black women. However, the majority of studies investigating cardiovascular disease associated with HIV infection have been conducted in the United States and Europe, in predominantly male cohorts.

scholarly journals Evaluation of Foliar Diseases for Soybean Entries in the Pan-African Trials in Malawi and Zambia

Plant Disease ◽  
2020 ◽  
Vol 104 (8) ◽  
pp. 2068-2073
Author(s):  
Christabell Nachilima ◽  
Godfree Chigeza ◽  
Mwila Chibanda ◽  
Hapson Mushoriwa ◽  
Brian D. Diers ◽  
...  
Keyword(s):  
Disease Severity ◽  
The United States ◽  
Sub Saharan Africa ◽  
Brown Spot ◽  
Soybean Rust ◽  
Growth Stages ◽  
Foliar Diseases ◽  
Pan African ◽  
Private And Public ◽  
Sub Saharan

Soybean production has expanded worldwide including countries in sub-Saharan Africa. Several national and international agencies and research groups have partnered to improve overall performance of soybean breeding stocks and have introduced new germplasm from Brazil and the United States with the goal of developing new high-yielding cultivars. Part of this effort has been to test improved soybean lines/cultivars accumulated from private and public sources in multilocational trials in sub-Saharan Africa. These trials are known as the Pan-African Soybean Variety Trials, and the entries come from both private and public breeding programs. The objective of this research was to evaluate entries in the trials that include commercial cultivars or advanced experimental lines for the incidence and severity of foliar diseases. All trials were planted in December 2018 with six located in Zambia and one in Malawi. Plants were evaluated during the reproductive growth stages using a visual pretransformed severity rating scale. Foliar disease ratings were recorded for three bacterial diseases, six fungal diseases, one oomycete, and viruses. The overall occurrence of most of the diseases was high except for soybean rust and target spot, which were only found at two and one location, respectively. However, disease severity was generally low, although there were differences in disease severity ratings among the entries at some of the locations for brown spot, downy mildew, frogeye leaf spot, red leaf blotch, and soybean rust.

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