Risk of Clostridium difficile-Associated Disease Among Patients Receiving Proton-Pump Inhibitors in a Quebec Medical Intensive Care Unit

2007 ◽  
Vol 28 (11) ◽  
pp. 1305-1307 ◽  
Author(s):  
Mathieu Beaulieu ◽  
David Williamson ◽  
Gilbert Pichette ◽  
Jean Lachaine
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Clostridium Difficile ◽  
Gastric Acid ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Medical Intensive Care Unit ◽  
Antibiotic Use ◽  
Medical Intensive Care

Our study was conducted to determine whether use of gastric acid-suppressive agents increased the risk of Clostridium difficile-associated disease (CDAD) in a medical intensive care unit of one of the first hospitals to be threatened by the current CDAD epidemic in Quebec, Canada. Our findings suggest that efforts to determine risk factors for CDAD should focus on other areas, such as older age and antibiotic use.

Sa1158 Overuse of Proton Pump Inhibitors in a University Medical Intensive Care Unit

2012 ◽  
Vol 142 (5) ◽  
pp. S-231
Author(s):  
Curtis R. Weaver ◽  
Danielle Marino ◽  
Arthur J. DeCross ◽  
Michael Apostolakos
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Medical Intensive Care Unit ◽  
Medical Intensive Care

scholarly journals Risk factors and clinical outcomes of arrhythmias in the medical intensive care unit

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Rodrigo J. Valderrábano ◽  
Alejandro Blanco ◽  
Eduardo J. Santiago-Rodriguez ◽  
Christine Miranda ◽  
José Rivera-del Rio del Rio ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Clinical Outcomes ◽  
Medical Intensive Care Unit ◽  
Medical Intensive Care

scholarly journals Risk factors for broncho-pulmonary nosocomial infection in medical intensive care unit

Critical Care ◽  
2001 ◽  
Vol 5 (Suppl 1) ◽  
pp. P044
Author(s):  
S Nseir ◽  
C Dipompeo ◽  
T Onimus ◽  
S Beague ◽  
B Grandbastien ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Nosocomial Infection ◽  
Medical Intensive Care Unit ◽  
Medical Intensive Care

scholarly journals 692: RISK FACTORS ASSOCIATED WITH SUBOPTIMAL TOBRAMYCIN LEVELS IN THE MEDICAL INTENSIVE CARE UNIT

2021 ◽  
Vol 50 (1) ◽  
pp. 340-340
Author(s):  
Jacob Counts ◽  
Jessica Elefritz ◽  
Erica Reed ◽  
Connor Aossey ◽  
Marilly Palettas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Medical Intensive Care Unit ◽  
Factors Associated ◽  
Medical Intensive Care

scholarly journals 1099. The Correlation Between Antimicrobial Utilization and Resistance in a Medical Intensive Care Unit

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S390-S391
Author(s):  
John W Ahern ◽  
Lindsay Smith ◽  
W Kemper Alston
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Medical Intensive Care Unit ◽  
Resistance Index ◽  
Antibiotic Use ◽  
Multidrug Resistant ◽  
Antimicrobial Utilization ◽  
Multidrug Resistant Organisms ◽  
Medical Intensive Care ◽  
The Relationship

Abstract Background The relationship between antimicrobial utilization and the incidence of antimicrobial-resistant pathogens can be obscured by a lack of longitudinal data. We used 9 years of antimicrobial utilization data combined with a unique metric of antimicrobial resistance to examine this relationship. Methods The medical intensive care unit (MICU) at UVMMC has 22 beds. The unit’s size and location did not change during the study. Since 2010, defined daily doses (DDD) in the MICU for ceftazidime, ceftriaxone, cefepime, ciprofloxacin, levofloxacin, piperacillin–tazobactam, meropenem, and vancomycin were measured. Concurrently, a database of positive cultures acquired in MICU, whether colonization or infection, was built for 6 selected organisms: Clostridioides difficile, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, ceftazidime-resistant Gram-negative bacilli, fluoroquinolone-resistant Pseudomonas aeruginosa (QRPA), and Stenotrophomonas maltophilia. The occurrence of these 6 organisms/1,000 patient-days is termed “resistance index.” Data for both metrics were collected in the same way, by the same person, throughout. The relationship between these 2 measures was analyzed with simple linear regression. Results From 2010 to 2018, the use of 8 broad-spectrum antibiotics fell in a linear fashion from 12.11 to 4.39 DDD/100,000 patient-days. The resistance index for the 6 multidrug-resistant organisms in MICU also fell in parallel from 6.5 to 1.5/1,000 patient-days (figure, r = 0.9, P = 0.001). For the 2 quinolones specifically, use fell from 2.26 to 0.18 DDD/100,000 patient-days, while the occurrence of QRPA fell from 1.5 to 0/1,000 patient-days (figure, r = 0.84, P = 0.004). Conclusion These longitudinal data, collected consistently over 9 years, clearly demonstrate a significant correlation between broad-spectrum antibiotic use and the occurrence of multidrug-resistant organisms in a MICU. A steep, linear decline in antibiotic use was correlated with a parallel fall in these 6 organisms. These data demonstrate that sustained, meaningful reductions in antimicrobial utilization in a MICU can result in significant reductions in the incidence of antimicrobial-resistant pathogens. Disclosures All authors: No reported disclosures.

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