scholarly journals Human Herpesvirus 8 as a Potential Sexually Transmitted Agent in Honduras

1998 ◽  
Vol 178 (2) ◽  
pp. 547-551 ◽  
Author(s):  
C. Sosa ◽  
W. Klaskala ◽  
B. Chandran ◽  
R. Soto ◽  
L. Sieczkowski ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Sexually Transmitted

Sexual behaviour and human herpesvirus 8 infection in homosexual men in Australia

Sexual Health ◽  
2005 ◽  
Vol 2 (1) ◽  
pp. 13 ◽  
Author(s):  
Andrew E. Grulich ◽  
Philip Cunningham ◽  
Mee-Ling Munier ◽  
Garrett Prestage ◽  
Janaki Amin ◽  
...  
Keyword(s):  
Sexual Behaviour ◽  
Sexual Transmission ◽  
Human Herpesvirus ◽  
Immunofluorescence Assay ◽  
Human Herpesvirus 8 ◽  
Homosexual Men ◽  
Anal Sex ◽  
Herpesvirus 8 ◽  
Sexually Transmitted ◽  
Receptive Anal Sex

Background: Human herpesvirus 8 (HHV-8) is a common sexually transmitted agent among homosexual men, but there are few Australian data. We aimed to describe the prevalence and risk factors for seropositivity to HHV-8 in Australian homosexual men. Methods: We conducted a prospective cohort study of 179 homosexual men in Sydney Australia in 1992–1998. Detailed data on sexual behaviour was collected annually, and HHV-8 status was determined at the end of the study by an algorithm based on results of an immunofluorescence assay and an enzyme-linked immunoassay to the K8.1 protein of HHV-8. HHV-8 DNA was detected in buffy coats using a nested qualitative PCR. Results: Data on sexual behaviour in at least three interviews and HHV-8 status were available in 174 (97%) of 179 men who agreed to participate. Of these, 31 (18%) were HHV-8 seropositive, and HHV-8 DNA was detected in 5 (16%) of these. The prevalence of HHV-8 infection was much higher in HIV positive (52%) than HIV negative (11%) men (OR 8.60, 95% CI 3.55–20.86). HHV-8 infection was related to more frequent reporting of unprotected receptive anal sex (OR for most frequent versus least frequent category 3.03, 95% CI 1.01–9.03, P trend 0.02), insertive oro–anal sex (OR for most frequent v. least frequent category 3.02, 95% CI 1.15–7.93, P trend 0.02) and receptive oro–anal sex (OR for most frequent v. least frequent category 3.09, 95% CI 1.11–8.60, P trend 0.05) with casual partners. Conclusions: These data are consistent with sexual transmission of HHV-8, but the precise mode of HHV-8 transmission remains unclear. Studies to elucidate the precise mode of sexual transmission of HHV-8 need to focus on potential salivary transmission, and should collect data on the HHV-8 infection and excretion status of the sexual partner.

scholarly journals Seropositivity to human herpesvirus 8 in relation to sexual history and risk of sexually transmitted infections among women

2000 ◽  
Vol 87 (2) ◽  
pp. 232-235 ◽  
Author(s):  
Rosamaria Tedeschi ◽  
Laura Caggiari ◽  
Ilvars Silins ◽  
Ingegerd Kallings ◽  
Agneta Andersson-Ellström ◽  
...  
Keyword(s):  
Sexually Transmitted Infections ◽  
Human Herpesvirus ◽  
Sexual History ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Sexually Transmitted

scholarly journals Human Herpesvirus 8 in the Prostate Glands of Men with Kaposi’s Sarcoma

1998 ◽  
Vol 72 (7) ◽  
pp. 6223-6227 ◽  
Author(s):  
Catherine Diamond ◽  
Scott J. Brodie ◽  
John N. Krieger ◽  
Meei-Li Huang ◽  
David M. Koelle ◽  
...  
Keyword(s):  
Kaposi's Sarcoma ◽  
Transrectal Ultrasound ◽  
Human Herpesvirus ◽  
Kaposi’S Sarcoma ◽  
Prostate Tissue ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Sexually Transmitted ◽  
Prostate Biopsies

ABSTRACT The epidemiology of human immunodeficiency virus (HIV)-associated Kaposi’s sarcoma (KS) resembles that of a sexually transmitted pathogen. However, human herpesvirus 8 (HHV-8), the proposed cause of KS, is found in semen only infrequently and at low titers. To determine whether HHV-8 was present in the urogenital tract, transrectal ultrasound-guided prostate biopsies were obtained from six men with KS (five with concurrent HIV infection) and four without KS (three with concurrent HIV) and assayed for HHV-8 by PCR. Nine of the 10 men were seropositive for HHV-8. Five of nine HHV-8-seropositive men had HHV-8 DNA detected in prostate tissue by solution-based PCR. All five currently had KS or had it previously. In two subjects, prostate tissue was the only identified source of HHV-8. In situ PCR on serial sections of prostate indicated that HHV-8 infection was localized to discrete areas of the prostate. When detected, HHV-8 DNA was present in the nuclei of >90% of the glandular epithelial cells. In situ hybridization for HHV-8 mRNA revealed that between 1 and 5% of cells harboring HHV-8 DNA expressed viral transcripts associated with HHV-8 replication (T1.1 transcript), while >90% expressed gene products associated with viral latency (T0.7 transcript). Intermittent replication of HHV-8 in the prostate and subsequent shedding of virus in semen may be crucial factors for determining whether HHV-8 can be transmitted through sexual activity.

Human herpesvirus 8 infection of the genital tract of HIV-seropositive and HIV-seronegative women at risk of sexually transmitted diseases

AIDS ◽  
2000 ◽  
Vol 14 (8) ◽  
pp. 1073 ◽  
Author(s):  
Guy Boivin ◽  
Catherine Hankins ◽  
Normand Lapointe ◽  
Sharon Walmsley ◽  
Annie Gaudreau ◽  
...  
Keyword(s):  
At Risk ◽  
Sexually Transmitted Diseases ◽  
Genital Tract ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Sexually Transmitted ◽  
Hiv Seropositive

scholarly journals Incidence of Human Herpesvirus 8 (HHV-8) infection among HIV-uninfected individuals at high risk for sexually transmitted infections

2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Massimo Giuliani ◽  
Paola Cordiali-Fei ◽  
Concetta Castilletti ◽  
Aldo Di Carlo ◽  
Guido Palamara ◽  
...  
Keyword(s):  
High Risk ◽  
Sexually Transmitted Infections ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Sexually Transmitted
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