scholarly journals Doxycycline Reduces Mortality to Lethal Endotoxemia by Reducing Nitric Oxide Synthesis via an Interleukin‐10‐Independent Mechanism

1998 ◽  
Vol 177 (2) ◽  
pp. 489-492 ◽  
Author(s):  
Pietro D'Agostino ◽  
Marzia La Rosa ◽  
Caterina Barbera ◽  
Francesco Arcoleo ◽  
Gloria Di Bella ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Interleukin 10 ◽  
Nitric Oxide Synthesis ◽  
Independent Mechanism

Endothelium-dependent and -independent vasodilation of isolated rat aorta induced by caffeine

1995 ◽  
Vol 269 (5) ◽  
pp. H1679-H1684 ◽  
Author(s):  
Y. Hatano ◽  
K. Mizumoto ◽  
T. Yoshiyama ◽  
M. Yamamoto ◽  
H. Iranami
Keyword(s):  
Nitric Oxide ◽  
Phosphodiesterase Inhibitor ◽  
Rat Aorta ◽  
Content Increase ◽  
Nitric Oxide Synthesis ◽  
Cyclic Monophosphate ◽  
Endothelial Denudation ◽  
Independent Mechanism ◽  
Isolated Rat ◽  
Dependent Mechanism

Caffeine (10(-4)-10(-3) M) induced concentration-dependent relaxations of phenylephrine-precontracted rat aortic rings with endothelium. Endothelial denudation significantly, but only partially, attenuated caffeine-induced relaxation. Pretreatment with NG-nitro-L-arginine, oxyhemoglobin, and methylene blue attenuated the relaxations to an extent similar to endothelial denudation. Guanosine 3',5'-cyclic monophosphate (cGMP) and adenosine 3',5'-cyclic monophosphate (cAMP) contents of aortic strips with endothelium increased significantly after exposure to caffeine (10(-3) M). Endothelial denudation attenuated caffeine-induced cGMP increase. Pretreatment with ryanodine (2 x 10(-5) M), which has been shown to combine with receptors on endoplasmic reticulum (ER) of endothelium, attenuated caffeine-induced relaxation and cGMP content increase of rings with endothelium. Pretreatment with caffeine potentiated sodium nitroprusside-induced relaxations and cGMP increase of rings without endothelium. These results demonstrated that caffeine-induced relaxation comprises two components. In the endothelium-dependent mechanism, caffeine promotes nitric oxide synthesis in endothelium by release of Ca2+ from ER through a ryanodine-sensitive Ca2+ channel, and the suppression of cGMP degradation also contributes to the relaxation. In the endothelium-independent mechanism, caffeine acts as a 3',5'-cyclic-nucleotide phosphodiesterase inhibitor.

scholarly journals Sustained Nitric Oxide Synthesis Contributes to Immunopathology in Ongoing Myocarditis Attributable to Interleukin-10 Disorders

2006 ◽  
Vol 169 (6) ◽  
pp. 2085-2093 ◽  
Author(s):  
Gudrun Szalay ◽  
Martina Sauter ◽  
Joachim Hald ◽  
Andreas Weinzierl ◽  
Reinhard Kandolf ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Interleukin 10 ◽  
Nitric Oxide Synthesis

Age-Dependence in Alterations in Nitric Oxide Synthesis in Cardiovascular System during Adaptation to Physical Training

2010 ◽  
Vol 1 (4) ◽  
pp. 345-356 ◽  
Author(s):  
O. V. Bazilyuk ◽  
Anatolii V. Kotsuruba ◽  
Lyubov. G. Stepanenko ◽  
Sergey A. Talanov ◽  
Yu. P. Korchak ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular System ◽  
Physical Training ◽  
Nitric Oxide Synthesis ◽  
Age Dependence

Chronic Inhibition of Endothelium-Derived Nitric Oxide Synthesis Causes Coronary Microvascular Structural Changes and Hyperreactivity to Serotonin in Pigs

Circulation ◽  
1995 ◽  
Vol 92 (9) ◽  
pp. 2636-2644 ◽  
Author(s):  
Akira Ito ◽  
Kensuke Egashira ◽  
Toshiaki Kadokami ◽  
Yoshihiro Fukumoto ◽  
Tsuneo Takayanagi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Structural Changes ◽  
Nitric Oxide Synthesis

Effects of Long-term Nitric Oxide Synthesis Inhibition on Plasma Volume Expansion and Fetal Growth in the Pregnant Rat

Hypertension ◽  
1995 ◽  
Vol 26 (6) ◽  
pp. 1019-1023 ◽  
Author(s):  
Sofía P. Salas ◽  
Fernando Altermatt ◽  
Mauricio Campos ◽  
Andrea Giacaman ◽  
Pedro Rosso
Keyword(s):  
Nitric Oxide ◽  
Fetal Growth ◽  
Plasma Volume ◽  
Volume Expansion ◽  
Nitric Oxide Synthesis ◽  
Plasma Volume Expansion ◽  
Pregnant Rat ◽  
Synthesis Inhibition

Arginine Vasopressin Increases Nitric Oxide Synthesis in Cytokine-Stimulated Rat Cardiac Myocytes

Hypertension ◽  
1997 ◽  
Vol 30 (5) ◽  
pp. 1112-1120 ◽  
Author(s):  
Keiji Yamamoto ◽  
Uichi Ikeda ◽  
Koji Okada ◽  
Toshikazu Saito ◽  
Yasuhiro Kawahara ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiac Myocytes ◽  
Arginine Vasopressin ◽  
Nitric Oxide Synthesis ◽  
Rat Cardiac Myocytes

Parathyroid Hormone–Related Protein Upregulates Interleukin-1β–Induced Nitric Oxide Synthesis

Hypertension ◽  
1997 ◽  
Vol 30 (4) ◽  
pp. 922-927 ◽  
Author(s):  
Bingbing Jiang ◽  
Shigeto Morimoto ◽  
Jin Yang ◽  
Keisuke Fukuo ◽  
Atsushi Hirotani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Parathyroid Hormone ◽  
Interleukin 1Β ◽  
Nitric Oxide Synthesis ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein
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