scholarly journals Regulation of Interleukin‐12 by Interleukin‐10, Transforming Growth Factor‐β, Tumor Necrosis Factor‐α, and Interferon‐γ in Human Monocytes Infected withMycobacterium tuberculosisH37Ra

1998 ◽  
Vol 178 (4) ◽  
pp. 1105-1114 ◽  
Author(s):  
S. A. Fulton ◽  
J. V. Cross ◽  
Z. T. Toossi ◽  
W. H. Boom
Keyword(s):  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Interleukin 10 ◽  
Interferon Γ ◽  
Interleukin 12 ◽  
Human Monocytes ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Evaluation of Interleukin-1α, Interleukin-10, Tumor Necrosis Factor-α and transforming Growth Factor-β in the Serum of Patients with Pemphigus Vulgaris

2014 ◽  
Vol 15 (6) ◽  
pp. 746-749 ◽  
Author(s):  
Faezeh Khozeimeh ◽  
Omid Savabi ◽  
Masih Esnaashari
Keyword(s):  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Transforming Growth Factor ◽  
Pemphigus Vulgaris ◽  
Transforming Growth Factor Β ◽  
Interleukin 10 ◽  
Tnf Α ◽  
Interleukin 1Α ◽  
Factor Α ◽  
Necrosis Factor

ABSTRACT Pemphigus is an autoimmune blistering disease characterized by a loss of cell adhesion result in acantholysis. Genetic factors and immunologic factors such as cytokines particularly IL-1α, IL-10, TNF-α, and TGF-β may counterpart to developing of Pemphigus. The aim of this study was to evaluate. The concentration of IL-1α, IL-10, TNF-α, TGF-α in serum of pemphigus vulgaris (PV) patients and normal individuals. Material and methods In this analytic and descriptive study 25 patients with pemphigus vulgaris (in active phase) and 25 healthy persons were examined. Serum samples of two groups were obtained and the level of IL-1α, IL-10, TNF-α and TGF-β were measured by ELISA technique. The data were analyzed statistically by independent T test (α = 0/05). Results All cytokines tested, showed higher concentration in patient's sera comparing to healthy control individuals. The level of IL-1α (p = 0.004), TNF-α (p = 0.008) and TGF-β (p = 0.009) were statistically different in two experimental groups, There was no significant difference in IL-10 level (p = 0.605). Conclusion Cytokines such as IL-1α, IL-10, TNF-α and TGF-β probably have a role in pathogenesis of PV. Further comprehensive studies are suggested to confirm these findings. How to cite this article Khozeimeh F, Savabi O, Esnaashari M. Evaluation of Interleukin-1α, Interleukin-10, Tumor Necrosis Factor-α and transforming Growth Factor-β in the Serum of Patients with Pemphigus Vulgaris. J Contemp Dent Pract 2014;15(6):746-749.

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