scholarly journals CHD7 Gene Polymorphisms Are Associated with Susceptibility to Idiopathic Scoliosis

2007 ◽  
Vol 80 (5) ◽  
pp. 957-965 ◽  
Author(s):  
Xiaochong Gao ◽  
Derek Gordon ◽  
Dongping Zhang ◽  
Richard Browne ◽  
Cynthia Helms ◽  
...  
Keyword(s):  
Idiopathic Scoliosis ◽  
Gene Polymorphisms ◽  
Chd7 Gene

scholarly journals CHD7 Gene Polymorphisms and Familial Idiopathic Scoliosis

Spine ◽  
2013 ◽  
Vol 38 (22) ◽  
pp. E1432-E1436 ◽  
Author(s):  
Mera K. Tilley ◽  
Cristina M. Justice ◽  
Kandice Swindle ◽  
Beth Marosy ◽  
Alexander F. Wilson ◽  
...  
Keyword(s):  
Idiopathic Scoliosis ◽  
Gene Polymorphisms ◽  
Chd7 Gene

scholarly journals Association of calmodulin1 gene polymorphisms with susceptibility to adolescent idiopathic scoliosis

2009 ◽  
Vol 1 (1) ◽  
pp. 58-65 ◽  
Author(s):  
Dong Zhao ◽  
Gui-xing Qiu ◽  
Yi-peng Wang ◽  
Jian-guo Zhang ◽  
Jian-xiong Shen ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Gene Polymorphisms

scholarly journals CHD7 gene polymorphisms in female patients with idiopathic scoliosis

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Karolina Borysiak ◽  
Piotr Janusz ◽  
Mirosław Andrusiewicz ◽  
Małgorzata Chmielewska ◽  
Mateusz Kozinoga ◽  
...  
Keyword(s):  
Idiopathic Scoliosis ◽  
Cobb Angle ◽  
Gene Polymorphisms ◽  
Control Group ◽  
Polymorphism Analysis ◽  
Progression Rate ◽  
Study Group ◽  
Wild Allele ◽  
Genetic Examination ◽  
Curve Severity

Abstract Background The CHD7 (chromosome domain helicase DNA binding protein 7) gene has been associated with familial idiopathic scoliosis (IS) in families of European descent. The CHD7 single-nucleotide polymorphisms have never been studied in Polish Caucasian IS patients. Methods The aim of this study was to investigate the relationship of CHD7 gene polymorphisms with susceptibility to or progression of IS in Polish Caucasian females. The study group comprised 211 females who underwent clinical, radiological and genetic examination. The study group was analyzed in three subgroups according to: (1) Cobb angle (Cobb angle ≤30° vs. Cobb angle ≥35°), (2) age of diagnosis (adolescent IS vs. early-onset IS) and (3) rate of progression (non-progressive vs. slowly progressive vs. rapidly progressive IS). The control group comprised 83 females with no scoliosis and with a negative family history who underwent clinical and genetic examination. In total six CHD7 gene polymorphisms were examined. Three polymorphisms (rs1017861, rs13248429, and rs4738813) were examined by RFLP (restriction fragment length polymorphism) analysis, and three were quantified by Sanger sequencing (rs78874766, rs4738824, and rs74797613). Results In rs13248429, rs78874766, and rs74797613 polymorphisms only the wild allele was present. The rs1017861 polymorphism demonstrated an association with IS susceptibility (p < 0.01). Two polymorphisms, rs1017861 and rs4738813, were associated with curve severity and progression rate (p < 0.05). None of the evaluated polymorphisms in CHD7 gene showed any association with the age of IS onset. Conclusions The polymorphism rs1017861 in CHD7 gene showed an association with IS susceptibility. Two polymorphisms (rs1017861 and rs4738813) were associated with curve severity and progression rate. None of the evaluated polymorphisms in CHD7 gene showed any association with the age of IS onset. Further evaluation of CHD7 gene should be considered as IS modifying factor.

Association of Estrogen Receptor β Gene Polymorphisms With Susceptibility to Adolescent Idiopathic Scoliosis

Spine ◽  
2009 ◽  
Vol 34 (8) ◽  
pp. 760-764 ◽  
Author(s):  
Hong-Qi Zhang ◽  
Shi-Jin Lu ◽  
Ming-Xing Tang ◽  
Ling-Qiang Chen ◽  
Shao-Hua Liu ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Gene Polymorphisms ◽  
Estrogen Receptor Β

scholarly journals Association between ladybird homeobox 1 gene polymorphisms and adolescent idiopathic scoliosis

Medicine ◽  
2019 ◽  
Vol 98 (27) ◽  
pp. e16314 ◽  
Author(s):  
Hua Jiang ◽  
Qinghua Yang ◽  
Yang Liu ◽  
Yewen Guan ◽  
Xinli Zhan ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Gene Polymorphisms

Association Between Estrogen Receptor Gene Polymorphisms and Curve Severity of Idiopathic Scoliosis

Spine ◽  
2002 ◽  
Vol 27 (21) ◽  
pp. 2357-2362 ◽  
Author(s):  
Masatoshi Inoue ◽  
Shohei Minami ◽  
Yoshinori Nakata ◽  
Hiroshi Kitahara ◽  
Yoshinori Otsuka ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Idiopathic Scoliosis ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Estrogen Receptor Gene ◽  
Receptor Gene Polymorphisms ◽  
Curve Severity
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