scholarly journals Reconstitution of Herpes Simplex Virus–Specific T Cell Immunity in HIV‐Infected Patients Receiving Highly Active Antiretroviral Therapy

2007 ◽  
Vol 195 (3) ◽  
pp. 410-415 ◽  
Author(s):  
Meghna Ramaswamy ◽  
Anele Waters ◽  
Colette Smith ◽  
Emma Hainsworth ◽  
Gareth Hardy ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
T Cell Immunity ◽  
Highly Active ◽  
Cell Immunity ◽  
Simplex Virus

scholarly journals Frequent Reactivation of Herpes Simplex Virus among HIV‐1–Infected Patients Treated with Highly Active Antiretroviral Therapy

2004 ◽  
Vol 190 (4) ◽  
pp. 693-696 ◽  
Author(s):  
Christine M. Posavad ◽  
Anna Wald ◽  
Steven Kuntz ◽  
Meei Li Huang ◽  
Stacy Selke ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active ◽  
Simplex Virus ◽  
Hiv 1

scholarly journals Cutting Edge: Priming of CD8 T Cell Immunity to Herpes Simplex Virus Type 1 Requires Cognate TLR3 Expression InVivo

2010 ◽  
Vol 184 (5) ◽  
pp. 2243-2246 ◽  
Author(s):  
Gayle M. Davey ◽  
Magdalena Wojtasiak ◽  
Anna I. Proietto ◽  
Francis R. Carbone ◽  
William R. Heath ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Cell Immunity ◽  
Simplex Virus

scholarly journals Subclinical Genital Herpes Shedding in HIV/Herpes Simplex Virus 2-Coinfected Women during Antiretroviral Therapy Is Associated with an Increase in HIV Tissue Reservoirs and Potentially Promotes HIV Evolution

2020 ◽  
Vol 95 (1) ◽  
Author(s):  
Tajanna Stinn ◽  
Steve Kuntz ◽  
Dana Varon ◽  
Meei-Li Huang ◽  
Stacy Selke ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Immune Responses ◽  
Recent Common Ancestor ◽  
Hiv Replication ◽  
Hiv Dna ◽  
Biopsy Specimens ◽  
Simplex Virus

ABSTRACT Antigen (Ag)-specific immune responses to chronic infections, such as herpes simplex virus type 2 (HSV-2) in HIV/HSV-coinfected persons, may sustain HIV tissue reservoirs by promoting T-cell proliferation but are poorly studied in women on antiretroviral therapy (ART). Mixed anogenital swabs and cervical secretions were self-collected by nine HIV/HSV-2-coinfected women during ART for 28 days to establish subclinical HSV DNA shedding rates and detection of HIV RNA by real-time PCR. Typical herpes lesion site biopsy (TLSB) and cervical biopsy specimens were collected at the end of the daily sampling period. Nucleic acids (NA) isolated from biopsy specimens had HIV quantified and HIV envC2-V5 single-genome amplification (SGA) and T-cell receptor (TCR) repertoires assessed. Women had a median CD4 count of 537 cells/μl (IQR: 483 to 741) at enrollment and HIV plasma viral loads of <40 copies/ml. HSV DNA was detected on 12% of days (IQR: 2 to 25%) from anogenital specimens. Frequent subclinical HSV DNA shedding was associated with increased HIV DNA tissue concentrations and increased divergence from the most recent common ancestor (MRCA), an indicator of HIV replication. Distinct predominant TCR clones were detected in cervical and TLSB specimens in a woman with frequent HSV DNA shedding, with mixing of minor variants between her tissues. In contrast, more limited TCR repertoire mixing was observed in two women with less frequent subclinical HSV DNA shedding. Subclinical HSV shedding in HIV/HSV-coinfected women during ART may sustain HIV tissue reservoirs via Ag exposure or HIV replication. This study provides evidence supporting further study of interventions targeting suppression of Ag-specific immune responses as a component of HIV cure strategies. IMPORTANCE Persons with HIV infection are frequently coinfected with chronic herpesviruses, which periodically replicate and produce viable herpes virions, particularly in anogenital and cervical tissues. Persistent protein expression results in proliferation of CD8+ and CD4+ T cells, and the latter could potentially expand and sustain HIV tissue reservoirs. We found HSV genital shedding rates were positively correlated with HIV DNA concentrations and HIV divergence from ancestral sequences in tissues. Our work suggests that immune responses to common coinfections, such as herpesviruses, may sustain HIV tissue reservoirs during suppressive ART, suggesting future cure strategies should study interventions to suppress replication or reactivation of chronic herpes infections.

T.109. Lipopeptide Vaccine Induces T Cell Immunity to Ocular Herpes Simplex Virus Type 1 in Human Leukocyte Antigen-(HLA)-A⁎0201 Transgenic Rabbit Model

2009 ◽  
Vol 131 ◽  
pp. S82-S83
Author(s):  
Aziz Alami Chentoufi ◽  
Gargi Dasgupta ◽  
Arfan Azeem ◽  
Zareen Choudhury ◽  
Anthony Nesburn ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Rabbit Model ◽  
Human Leukocyte ◽  
T Cell Immunity ◽  
Leukocyte Antigen ◽  
Cell Immunity ◽  
Ocular Herpes ◽  
Simplex Virus

scholarly journals Antigen-driven CD4+ T cell and HIV-1 dynamics: Residual viral replication under highly active antiretroviral therapy

1999 ◽  
Vol 96 (26) ◽  
pp. 15167-15172 ◽  
Author(s):  
N. M. Ferguson ◽  
F. deWolf ◽  
A. C. Ghani ◽  
C. Fraser ◽  
C. A. Donnelly ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Viral Replication ◽  
Highly Active Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Highly Active ◽  
Hiv 1
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