scholarly journals Molecular Population Genetics of the Gene Encoding the Human Fertilization Protein Zonadhesin Reveals Rapid Adaptive Evolution

2006 ◽  
Vol 79 (5) ◽  
pp. 820-830 ◽  
Author(s):  
Joe Gasper ◽  
Willie J. Swanson
Keyword(s):  
Population Genetics ◽  
Adaptive Evolution ◽  
Gene Encoding ◽  
Human Fertilization ◽  
Molecular Population Genetics

scholarly journals Haldane's Sieve and Adaptation From the Standing Genetic Variation

Genetics ◽  
2001 ◽  
Vol 157 (2) ◽  
pp. 875-884 ◽  
Author(s):  
H Allen Orr ◽  
Andrea J Betancourt
Keyword(s):  
Population Genetics ◽  
Genetic Variation ◽  
Environmental Change ◽  
Adaptive Evolution ◽  
Sex Expression ◽  
Background Selection ◽  
Beneficial Mutations ◽  
Deleterious Alleles ◽  
Molecular Population Genetics ◽  
New Mutations

Abstract We consider populations that adapt to a sudden environmental change by fixing alleles found at mutation-selection balance. In particular, we calculate probabilities of fixation for previously deleterious alleles, ignoring the input of new mutations. We find that “Haldane's sieve”—the bias against the establishment of recessive beneficial mutations—does not hold under these conditions. Instead probabilities of fixation are generally independent of dominance. We show that this result is robust to patterns of sex expression for both X-linked and autosomal loci. We further show that adaptive evolution is invariably slower at X-linked than autosomal loci when evolution begins from mutation-selection balance. This result differs from that obtained when adaptation uses new mutations, a finding that may have some bearing on recent attempts to distinguish between hitchhiking and background selection by contrasting the molecular population genetics of X-linked vs. autosomal loci. Last, we suggest a test to determine whether adaptation used new mutations or previously deleterious alleles from the standing genetic variation.

A Primer of Population Genetics and Genomics

2020 ◽  
Author(s):  
Daniel L. Hartl
Keyword(s):  
Population Genetics ◽  
Complex Traits ◽  
Evolutionary Biology ◽  
Knowledge Retention ◽  
Learning By Doing ◽  
Human Populations ◽  
Gene Drive ◽  
Molecular Population Genetics ◽  
Genetics And Genomics ◽  
And Mathematics

A Primer of Population Genetics and Genomics, 4th edition, has been completely revised and updated to provide a concise but comprehensive introduction to the basic concepts of population genetics and genomics. Recent textbooks have tended to focus on such specialized topics as the coalescent, molecular evolution, human population genetics, or genomics. This primer bucks that trend by encouraging a broader familiarity with, and understanding of, population genetics and genomics as a whole. The overview ranges from mating systems through the causes of evolution, molecular population genetics, and the genomics of complex traits. Interwoven are discussions of ancient DNA, gene drive, landscape genetics, identifying risk factors for complex diseases, the genomics of adaptation and speciation, and other active areas of research. The principles are illuminated by numerous examples from a wide variety of animals, plants, microbes, and human populations. The approach also emphasizes learning by doing, which in this case means solving numerical or conceptual problems. The rationale behind this is that the use of concepts in problem-solving lead to deeper understanding and longer knowledge retention. This accessible, introductory textbook is aimed principally at students of various levels and abilities (from senior undergraduate to postgraduate) as well as practising scientists in the fields of population genetics, ecology, evolutionary biology, computational biology, bioinformatics, biostatistics, physics, and mathematics.

scholarly journals Molecular Population Genetics and Evolution of the Chagas’ Disease Vector Triatoma infestans (Hemiptera: Reduviidae)

2013 ◽  
Vol 14 (5) ◽  
pp. 316-323 ◽  
Author(s):  
Beatriz García ◽  
Alicia R. Pérez Rosas ◽  
María Blariza ◽  
Carla Grosso ◽  
Cintia Fernández ◽  
...  
Keyword(s):  
Population Genetics ◽  
Chagas Disease ◽  
Triatoma Infestans ◽  
Disease Vector ◽  
Molecular Population Genetics

MOLECULAR POPULATION GENETICS OF SOCIAL INSECTS

1997 ◽  
Vol 28 (1) ◽  
pp. 1-25 ◽  
Author(s):  
Pekka Pamilo ◽  
Pia Gertsch ◽  
Peter Thorén ◽  
Perttu Seppä
Keyword(s):  
Population Genetics ◽  
Social Insects ◽  
Molecular Population Genetics
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