scholarly journals Mitochondrial DNA–Deletion Mutations Accumulate Intracellularly to Detrimental Levels in Aged Human Skeletal Muscle Fibers

2006 ◽  
Vol 79 (3) ◽  
pp. 469-480 ◽  
Author(s):  
Entela Bua ◽  
Jody Johnson ◽  
Allen Herbst ◽  
Bridget Delong ◽  
Debbie McKenzie ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Human Skeletal Muscle ◽  
Muscle Fibers ◽  
Mitochondrial Dna Deletion ◽  
Deletion Mutations ◽  
Dna Deletion ◽  
Skeletal Muscle Fibers

scholarly journals Accurate Measurement of Mitochondrial DNA Deletion Level and Copy Number Differences in Human Skeletal Muscle

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e114462 ◽  
Author(s):  
John P. Grady ◽  
Julie L. Murphy ◽  
Emma L. Blakely ◽  
Ronald G. Haller ◽  
Robert W. Taylor ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Copy Number ◽  
Human Skeletal Muscle ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion

Glycogen depletion patterns in human skeletal muscle fibers during prolonged work

1973 ◽  
Vol 344 (1) ◽  
pp. 1-12 ◽  
Author(s):  
P. D. Gollnick ◽  
R. B. Armstrong ◽  
C. W. Saubert ◽  
W. L. Sembrowich ◽  
R. E. Shepherd ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Muscle Fibers ◽  
Glycogen Depletion ◽  
Skeletal Muscle Fibers

Induction of GLUT-1 protein in adult human skeletal muscle fibers

2000 ◽  
Vol 279 (5) ◽  
pp. E1191-E1195 ◽  
Author(s):  
M. Gaster ◽  
J. Franch ◽  
P. Staehr ◽  
H. Beck-Nielsen ◽  
T. Smith ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Contractile Activity ◽  
Muscle Fibers ◽  
Insulin Dependent Diabetes Mellitus ◽  
Human Muscle ◽  
Dependent Diabetes Mellitus ◽  
Glut 1 ◽  
Adult Human ◽  
Skeletal Muscle Fibers

Prompted by our recent observations that GLUT-1 is expressed in fetal muscles, but not in adult muscle fibers, we decided to investigate whether GLUT-1 expression could be reactivated. We studied different stimuli concerning their ability to induce GLUT-1 expression in mature human skeletal muscle fibers. Metabolic stress (obesity, non-insulin-dependent diabetes mellitus), contractile activity (training), and conditions of de- and reinnervation (amyotrophic lateral sclerosis) could not induce GLUT-1 expression in human muscle fibers. However, regenerating muscle fibers in polymyositis expressed GLUT-1. In contrast to GLUT-1, GLUT-4 was expressed in all investigated muscle fibers. Although the significance of GLUT-1 in adult human muscle fibers appears limited, GLUT-1 may be of importance for the glucose supplies in immature and regenerating muscle.

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