scholarly journals Human Herpesvirus 6 Genome Integration: A Possible Cause of Misdiagnosis of Active Viral Infection?

2006 ◽  
Vol 194 (7) ◽  
pp. 1019-1020 ◽  
Author(s):  
David Boutolleau ◽  
Henri Agut ◽  
Agnès Gautheret‐Dejean
Keyword(s):  
Viral Infection ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Genome Integration ◽  
Herpesvirus 6 ◽  
Possible Cause

scholarly journals Association of Active Human Herpesvirus-6, -7 and Parvovirus B19 Infection with Clinical Outcomes in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Svetlana Chapenko ◽  
Angelika Krumina ◽  
Inara Logina ◽  
Santa Rasa ◽  
Maksims Chistjakovs ◽  
...  
Keyword(s):  
Viral Infection ◽  
Proinflammatory Cytokines ◽  
Parvovirus B19 ◽  
Human Herpesvirus ◽  
High Rate ◽  
Simultaneous Increase ◽  
Concurrent Infection ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Healthy Persons

Frequency of active human herpesvirus-6, -7 (HHV-6, HHV-7) and parvovirus B19 (B19) infection/coinfection and its association with clinical course of ME/CFS was evaluated. 108 ME/CFS patients and 90 practically healthy persons were enrolled in the study. Viral genomic sequences were detected by PCR, virus-specific antibodies and cytokine levels—by ELISA, HHV-6 variants—by restriction analysis. Active viral infection including concurrent infection was found in 64.8% (70/108) of patients and in 13.3% (12/90) of practically healthy persons. Increase in peripheral blood leukocyte DNA HHV-6 load as well as in proinflammatory cytokines' levels was detected in patients during active viral infection. Definite relationship was observed between active betaherpesvirus infection and subfebrility, lymphadenopathy and malaise after exertion, and between active B19 infection and multijoint pain. Neuropsychological disturbances were detected in all patients. The manifestation of symptoms was of more frequent occurrence in patients with concurrent infection. The high rate of active HHV-6, HHV-7 and B19 infection/coinfection with the simultaneous increase in plasma proinflammatory cytokines' level as well as the association between active viral infection and distinctive types of clinical symptoms shows necessity of simultaneous study of these viral infections for identification of possible subsets of ME/CFS.

scholarly journals Molecular Detection of Epstein - Barr virus and Human Herpesvirus-6 in a Sample of Iraqi Patients with Acute Leukemia

2020 ◽  
Vol 11 (2) ◽  
pp. 2234-2240
Author(s):  
Arwa Mujahid Al-Shuwaikh ◽  
Dalya Basil Hanna ◽  
Asmaa B. Al-Obaidi ◽  
Ghaith Ali Jasim
Keyword(s):  
Acute Leukemia ◽  
Viral Infection ◽  
Epstein Barr Virus ◽  
Hematological Parameters ◽  
Human Herpesvirus ◽  
Control Group ◽  
Human Herpesvirus 6 ◽  
Barr Virus ◽  
Herpesvirus 6 ◽  
Epstein Barr

The pathogenic roles of human herpesvirus-6 (HHV-6) and Epstein-Barr virus (EBV) in acute leukemia have been of great interest. Patients with leukemia should be evaluated for viral infection, so they could be diagnosed for optimal therapy. In the current study, we aimed to determine the frequency of HHV-6 and EBV in a sample of Iraqi patients with acute leukemia in children and adults before chemotherapy. Fluorescent probe-based quantitative polymerase chain reaction (Q-PCR) method was used to quantify copies of HHV-6 and EBV DNA in 20 cases of acute lymphoblastic leukemia (AML), and 40 cases of hematological stable control subjects. Also, the effects of viral infection on hematological parameters were investigated. Results show that (47.5%) 19 out of 40 of patients at diagnosis recorded positive to one of the investigated viruses. Thirteen (32.5%) and 12 (30%) out of 40 patients with acute leukemia had positive EBV and HHV-6 viremia, respectively, while none of control group shows positive result with highly significant differences between patients and control groups (P<0.001). The mean EBV and HHV-6 viral load was (7737.615±9106.838 copies/ml) and (94393.58±214528.9 copies/ml), respectively. In this study, there was no significant association between viral infection and hematological parameters (P>0.05).In conclusion, infections or co-infections with EBV and HHV-6 could be a factor in the development of acute leukemia but further studies are required to establish whether there is a real association.

scholarly journals Is There a Role for Human Herpesvirus–6 in the Course of Multiple Sclerosis?

2002 ◽  
Vol 4 (1) ◽  
pp. 30-39 ◽  
Author(s):  
Silvia Delgado ◽  
Micheline McCarthy
Keyword(s):  
Multiple Sclerosis ◽  
Viral Infection ◽  
Human Herpesvirus ◽  
Focused Attention ◽  
Human Herpesvirus 6 ◽  
Animal Virus ◽  
The Past ◽  
Specific Factors ◽  
Herpesvirus 6

Historically multiple sclerosis (MS) has been associated with many different viruses, including several members of the Herpesviridae family. However, no human or animal virus has been identified as a true “cause” of MS; rather, the epidemiologic and diagnostic data suggest that viral infection may be a cofactor affecting the pathogenesis of MS. Human herpesvirus-6 (HHV-6) is a ubiquitous herpesvirus associated with a common childhood illness, roseola, and this virus is one of those most recently associated with MS. During the past decade, a number of investigations have examined anti—HHV-6-specific antibody responses, HHV-6 viral DNA, or HHV-6 presence in central nervous system (CNS) tissue in both MS patients and controls. There is a growing body of evidence associating HHV-6 infection of the CNS with MS in at least a subpopulation of patients, although the specific factors that define the vulnerable subpopulation(s) of MS patients have not been elucidated. This evidence is provocative but not definitive, and it does not distinguish between HHV-6 as a causal agent in MS versus HHV-6 as a cofactor. Although more clinically based data are needed, the controversy surrounding HHV-6 and MS has again focused attention on the role of viral infection in the clinical and pathologic course of MS. (Int J MS Care. 2002; 4: 30–31, 36–39)

Sign in / Sign up

Export Citation Format

Share Document