scholarly journals Role of Hepatitis B Virus Precore/Core Promoter Mutations and Serum Viral Load on Noncirrhotic Hepatocellular Carcinoma: A Case‐Control Study

2006 ◽  
Vol 194 (5) ◽  
pp. 594-599 ◽  
Author(s):  
Chun‐Jen Liu ◽  
Bing‐Fang Chen ◽  
Pei‐Jer Chen ◽  
Ming‐Yang Lai ◽  
Wen‐Ling Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Viral Load ◽  
Case Control Study ◽  
Core Promoter ◽  
Case Control ◽  
Serum Viral Load ◽  
B Virus ◽  
Promoter Mutations ◽  
Control Study

scholarly journals Combined Mutations in Pre‐S/Surface and Core Promoter/Precore Regions of Hepatitis B Virus Increase the Risk of Hepatocellular Carcinoma: A Case-Control Study

2008 ◽  
Vol 198 (11) ◽  
pp. 1634-1642 ◽  
Author(s):  
Chien‐Hung Chen ◽  
Chi‐Sin Changchien ◽  
Chuan‐Mo Lee ◽  
Chao‐Hung Hung ◽  
Tsung‐Hui Hu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Core Promoter ◽  
Case Control ◽  
B Virus ◽  
Control Study

scholarly journals Association of MBOAT7-TMC4 rs641738 with the risk of hepatocellular carcinoma and persistent infection of hepatitis B virus: a case-control study and meta-analysis

2019 ◽  
Author(s):  
Peng Wang ◽  
Yu Zhou ◽  
Lu Li ◽  
Yajie Gong ◽  
Rong Zhong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Hbv Infection ◽  
B Virus ◽  
Control Study

Abstract Background: Recent studies reported that a hot genetic variant, rs641738 within the membrane bound O-acyltransferase domain containing 7(MBOAT7) and transmembrane channel-like 4 (TMC4) , was associated with several liver diseases. However, results are still conflicting. We conducted this study to explore the role of MBOAT7-TMC4 rs641738 in the risk of hepatocellular carcinoma (HCC) and persistent hepatitis B virus (HBV) infection. Methods: We first performed a case-control study by including 779 HCC cases and 1412 cancer-free controls. Controls are consisted of 678 HBV persistent carriers and 734 spontaneously recovered subjects. Rs641738 was genotyped by MassARRAY platform. Results were analyzed by multivariate logistic regression analysis under five genetic models. Second, we conducted a systematic review and meta-analysis to further explore the role of this variant in HCC risk. Results: Results suggested no association between MBOAT7-TMC4 rs641738 and HCC risk in most genetic models (All P > 0.05), although a marginally significant association was observed in TT vs. CC ( P = 0.037) and recessive model ( P = 0.044). Further meta-analysis including 2135 HCC cases and 4388 controls supported that this variant was not related to HCC risk, even in the TT vs. CC and recessive models. Besides, we identified that this variant also had no influence on persistent HBV infection. Conclusion: Our work highlights that MBOAT7-TMC4 rs641738 is not associated with the risk of HCC or persistent HBV infection. This study provides some clues to identify the “truth” of potential disease-related genetic factors in the post-genome era.

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