scholarly journals Antimicrobial Agents: Antibacterials and Antifungals Edited by Andre Bryskier Washington, DC: ASM Press, 2005. 1426 pp. $189.95 (cloth)

2006 ◽  
Vol 42 (12) ◽  
pp. 1816-1816 ◽  
Author(s):  
K. O. Cleveland
Keyword(s):  
Antimicrobial Agents ◽  
Washington Dc

scholarly journals In Vitro Activities of Three New Dihydrofolate Reductase Inhibitors against Clinical Isolates of Gram-Positive Bacteria

2009 ◽  
Vol 53 (11) ◽  
pp. 4949-4952 ◽  
Author(s):  
Karen E. Bowker ◽  
Patrick Caspers ◽  
Bérengère Gaucher ◽  
Alasdair P. MacGowan
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Agents ◽  
Washington Dc ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Reductase Inhibitors ◽  
Drug Classes ◽  
Vancomycin Resistant ◽  
Dihydrofolate Reductase Inhibitors

ABSTRACT BAL0030543, BAL0030544, and BAL0030545 are dihydrophthalazine inhibitors with in vitro potency against gram-positive pathogens. The MIC50s for methicillin (meticillin)-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, hetero-vancomycin-resistant Staphylococcus aureus, and vancomycin-resistant Staphylococcus aureus (VISA) range from 0.015 to 0.25 μg/ml (MIC90s ≤ 0.5 μg/ml). MIC50s for beta-hemolytic streptococci range from 0.03 to 0.06 μg/ml, MIC50s for Streptococcus pneumoniae range from 0.06 to 0.12 μg/ml, MIC50s for Listeria monocytogenes range from 0.015 to 0.06 μg/ml, and MIC50s for Streptococcus mitis are ≤0.015 μg/ml. These three dihydrophthalazine antifolates have improved potency compared to that of trimethoprim and activity against gram-positive pathogens resistant to other drug classes. (This work was presented in part at the 48th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, 2008 [1].)

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