scholarly journals Nucleic Acid Testing for West Nile Virus RNA in Plasma Enhances Rapid Diagnosis of Acute Infection in Symptomatic Patients

2006 ◽  
Vol 193 (10) ◽  
pp. 1361-1364 ◽  
Author(s):  
Peter A. G. Tilley ◽  
Julie D. Fox ◽  
Gayatri C. Jayaraman ◽  
Jutta K. Preiksaitis
Keyword(s):  
West Nile Virus ◽  
Nucleic Acid ◽  
Acute Infection ◽  
Rapid Diagnosis ◽  
Nucleic Acid Testing ◽  
West Nile ◽  
Virus Rna

Collaborative study to evaluate a working reagent for West Nile virus RNA detection by nucleic acid testing

Transfusion ◽  
2005 ◽  
Vol 45 (1) ◽  
pp. 97-102 ◽  
Author(s):  
John Saldanha ◽  
Susan Shead ◽  
Alan Heath ◽  
Michael Drebot ◽  
Keyword(s):  
West Nile Virus ◽  
Nucleic Acid ◽  
Collaborative Study ◽  
Nucleic Acid Testing ◽  
West Nile ◽  
Rna Detection ◽  
Virus Rna

Probable transfusion transmission of West Nile virus from an apheresis platelet that screened non‐reactive by individual donor‐nucleic acid testing

Transfusion ◽  
2019 ◽  
Vol 60 (2) ◽  
pp. 424-429 ◽  
Author(s):  
Chelsea Hayes ◽  
Laura Stephens ◽  
Joy L. Fridey ◽  
Robert E. Snyder ◽  
Jamel A. Groves ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Nucleic Acid ◽  
Nucleic Acid Testing ◽  
West Nile ◽  
Individual Donor

West Nile virus testing experience in 2007: evaluation of different criteria for triggering individual-donation nucleic acid testing

Transfusion ◽  
2009 ◽  
Vol 49 (6) ◽  
pp. 1160-1170 ◽  
Author(s):  
Steven H. Kleinman ◽  
Joan Dunn Williams ◽  
Gene Robertson ◽  
Sally Caglioti ◽  
Robert C. Williams ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Nucleic Acid ◽  
Nucleic Acid Testing ◽  
West Nile ◽  
Virus Testing

Screening the Blood Supply for West Nile Virus RNA by Nucleic Acid Amplification Testing

2005 ◽  
Vol 353 (5) ◽  
pp. 460-467 ◽  
Author(s):  
Michael P. Busch ◽  
Sally Caglioti ◽  
Eugene F. Robertson ◽  
Joan D. McAuley ◽  
Leslie H. Tobler ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Nucleic Acid ◽  
Blood Supply ◽  
Nucleic Acid Amplification ◽  
West Nile ◽  
Nucleic Acid Amplification Testing ◽  
Virus Rna

scholarly journals Superiority of West Nile Virus RNA Detection in Whole Blood for Diagnosis of Acute Infection

2016 ◽  
Vol 54 (9) ◽  
pp. 2294-2297 ◽  
Author(s):  
Yaniv Lustig ◽  
Batya Mannasse ◽  
Ravit Koren ◽  
Shiri Katz-Likvornik ◽  
Musa Hindiyeh ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Whole Blood ◽  
Predictive Value ◽  
Acute Infection ◽  
The Other ◽  
Lower Sensitivity ◽  
West Nile ◽  
Rna Detection ◽  
Routine Diagnosis ◽  
Virus Rna

The current diagnosis of West Nile virus (WNV) infection is primarily based on serology, since molecular identification of WNV RNA is unreliable due to the short viremia and absence of detectable virus in cerebrospinal fluid (CSF). Recent studies have shown that WNV RNA can be detected in urine for a longer period and at higher concentrations than in plasma. In this study, we examined the presence of WNV RNA in serum, plasma, whole-blood, CSF, and urine samples obtained from patients diagnosed with acute WNV infection during an outbreak which occurred in Israel in 2015. Our results demonstrate that 33 of 38 WNV patients had detectable WNV RNA in whole blood at the time of diagnosis, a higher rate than in any of the other sample types tested. Overall, whole blood was superior to all other samples, with 86.8% sensitivity, 100% specificity, 100% positive predictive value, and 83.9% negative predictive value. Interestingly, WNV viral load in urine was higher than in whole blood, CSF, serum, and plasma despite the lower sensitivity than that of whole blood. This study establishes the utility of whole blood in the routine diagnosis of acute WNV infection and suggests that it may provide the highest sensitivity for WNV RNA detection in suspected cases.

scholarly journals West Nile virus blood transfusion-related infection despite nucleic acid testing

Transfusion ◽  
2004 ◽  
Vol 44 (12) ◽  
pp. 1695-1699 ◽  
Author(s):  
Alexandre Macedo de Oliveira ◽  
Brady D. Beecham ◽  
Susan P. Montgomery ◽  
Robert S. Lanciotti ◽  
Jeffrey M. Linnen ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Nucleic Acid ◽  
Blood Transfusion ◽  
Nucleic Acid Testing ◽  
West Nile
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