Bacitracin Versus Mupirocin for Staphylococcus aureus Nasal Colonization

1999 ◽  
Vol 20 (05) ◽  
pp. 351-353 ◽  
Author(s):  
Norberto E. Soto ◽  
Ashok Vaghjimal ◽  
Annette Stahl-Avicolli ◽  
John R. Protic ◽  
Larry I. Lutwick ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Prospective Study ◽  
Healthcare Workers ◽  
Day Treatment ◽  
Similar Efficacy ◽  
Nasal Colonization

AbstractWe performed a randomized prospective study of 5-day treatment with topical mupirocin or bacitracin for the elimination ofStaphylococcus aureusnasal colonization in healthcare workers (HCWs). Nasal cultures were obtained from 141 HCWs, 37 (26%) of whom showed Saureus.After 72 to 96 hours of treatment, the organism was eradicated in 15 (94%) of 16 by mupirocin and in 8 (44%) of 18 by bacitracin (P=.0031). Similar efficacy was demonstrated at 30 days. Mupirocin may be more effective than bacitracin for eradication of Saureusin healthy HCWs.

scholarly journals Methicillin-resistant Staphylococcus aureus colonization among healthcare workers in Oman

2021 ◽  
Vol 15 (10) ◽  
pp. 1426-1435
Author(s):  
Loay Al Wahaibi ◽  
Rajaa Al Sudairi ◽  
Abdullah Balkhair ◽  
Huda Al-Awaisi ◽  
Mohamed Mabruk
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Healthcare Workers ◽  
Nasal Swab ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Aureus Strain ◽  
Nasal Colonization ◽  
Methicillin Resistant ◽  
Associated Risk Factors ◽  
Mrsa Colonization

Introduction: Methicillin-Resistant Staphylococcus aureus (MRSA) is a S. aureus strain characterized by resistance to cloxacillin. Healthcare workers (HCWs), are recognized for their heightened risk for MRSA acquisition and possibly for MRSA nosocomial transmission. This cross-sectional study aimed to determine the prevalence and the associated risk factors of MRSA colonization among healthcare workers at Sultan Qaboos University Hospital (SQUH) in Oman. Methodology: A total of 200 nasal swab samples were collected from the healthcare workers at SQUH during the period October 2nd 2018 to January 7th 2019. All nasal swab samples were examined microbiologically for the presence of MRSA using the standard method and the results were confirmed by detection of the mecA product (PBP2a). Data on associated risk factors for MRSA colonization was collected and analyzed. Results: Forty-one of the 200 screened healthcare workers (20.5%) were found to have nasal carriage of Staphylococcus aureus of which 63.4% were Methicillin Sensitive and 36.6% were Methicillin-Resistant (MRSA). Methicillin-Resistant Staphylococcus aureus (MRSA) was isolated from fifteen of the 200 screened healthcare workers giving a prevalence rate of nasal colonization with MRSA of 7.5%. We found no statistical association between healthcare worker MRSA nasal colonization and age, gender, HCWs specialty, hand hygiene practices, skin condition, previous MRSA infection, and previous exposure to antibiotics. Conclusions: Identification of the prevalence and the associated risk factors of MRSA colonization in healthcare workers mandates continuous surveillance and the implementation of all possible preventive measures to reduce re-occurrences.

scholarly journals Genotyping of Staphylococcus aureus associated with nasal colonization among healthcare workers using DNA microarray

2018 ◽  
Vol 12 (05) ◽  
pp. 321-325 ◽  
Author(s):  
Abiola Catherine Senok ◽  
Ali Somily ◽  
Muhabat Raji ◽  
Ghada Garaween ◽  
Maha Kabil ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Dna Microarray ◽  
Healthcare Workers ◽  
Acid Resistance ◽  
Clonal Diversity ◽  
Nasal Colonization ◽  
Carriage Rate ◽  
Nasal Swabs ◽  
Staphylococcal Cassette Chromosome

Introduction: Healthcare workers (HCWs) colonized with Staphylococcus aureus may serve as a reservoir of infection. This study was carried to determine the genetic make-up of S. aureus nasal colonizers in HCWs. Methodology: Nasal swabs were obtained from 93 HCWs and molecular characterization of identified S. aureus isolates was carried out using the StaphyType DNA microarray (Alere Technologies GmbH, Jena, Germany). Results: Twenty-nine HCWs (31%) were colonized with S. aureus (MSSA = 23; MRSA = 6). Thus the overall MRSA carriage rate was 6.5% (n/N = 6/93) and 20.7% (n/N = 6/29) of those colonized with S. aureus harboured MRSA. The S. aureus isolates belonged to 16 clonal complexes (CC). MSSA isolates included three each for CC15, CC188, ST2867; two each for CC5, CC97, CC367 as well as one each for CC1, CC8, CC30, CC45, CC101, CC121, ST291/813 and CC1153. The staphylococcal cassette chromosome recombinase genes ccrA-1; ccrB-1 and the fusidic acid resistance gene (fusC) were present in two MSSA isolates (CC1 and CC8). The six MRSA isolates included CC5-MRSA-[VI+fusC] (n = 2); one each of CC5-MRSA-V; CC22-MRSA-IV (tst1+); CC80-MRSA-IV [pvl+] (“European CA-MRSA Clone”) and CC97-MRSA-[V+fusC]. Conclusion: There is wide clonal diversity of S. aureus colonizers with associated high MRSA carriage among the HCWs. The presence of genetically stable MSSA isolates with the capability to transform into MRSA isolates is of concern.

scholarly journals Nasal carriage of Staphylococcus aureus among healthcare workers in relation to patient contact

2020 ◽  
Author(s):  
Hsin-I Shih ◽  
Fan-Ching Shen ◽  
Yun-Ju Lee ◽  
Hsiang-Chin Hsu ◽  
Chiu-Hui Wu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Healthcare Workers ◽  
Care Facility ◽  
Nasal Carriage ◽  
Health Concern ◽  
Molecular Characteristics ◽  
Hospital Nurses ◽  
Nasal Colonization ◽  
Patient Contact ◽  
Term Care

Abstract Background : Methicillin-resistant Staphylococcus aureus (MRSA) is a major public health concern worldwide. Healthcare workers (HCWs) are an important source of transmission of MRSA. We conducted a prospective study to define the frequency of S. aureus nasal colonization and emphasize on the carriage of MRSA in HCWs in relation to the intensity of patient contact. Methods: To evaluate the prevalence of S. aureus carriage and the relevance of transmission from community to the hospital, MRSA and methicillin-susceptible S. aureus (MSSA) nasal colonization in selected HCWs was compared. These included an emergency department, intensive care unit, out-of-hospital care emergency medical technicians and students, and a long-term care facility (LTCF). The MRSA isolates were further identified by their microbiological and molecular characteristics. Results: S. aureus was isolated from 63 of 248 HCWs (25.4%). The overall MRSA nasal carriage rate was 15/248, 6%. Most MRSA carriers were female (14/15, 93.3%), and HCWs who had worked for ≥5 years (11/15, 73.3%). LTCFs had the highest prevalence (3/25, 12%). In contrast, the overall carriage of MSSA was 48/248, 19.4%, and most carriers worked for ≥5 years (25/48, 52.1%). Hospital nurses had the highest rate of MSSA carriage (22/103, 21.4%). Most of the MRSA isolates were SCC mec IV/ST59 or ST45 (60%), and were resistant to erythromycin and clindamycin (53%). Only one MRSA was chlorhexidine resistant. All produced low level of biofilms. Conclusions: This study demonstrates hospital nurses have highest S. aureus nasal carriage, whereas HCWs worked in the LTCFs have the highest prevalence of nasal MRSA colonization. The differences in the characteristics of MRSA and MSSA nasal carriage among HCWs highlights the importance on inclusion of all strains of S. aureus in surveillance and infection control programs.

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