scholarly journals Human Illness and Isolation of Low‐Pathogenicity Avian Influenza Virus of the H7N3 Subtype in British Columbia, Canada

2006 ◽  
Vol 193 (6) ◽  
pp. 899-900 ◽  
Author(s):  
Danuta M. Skowronski ◽  
S. Aleina Tweed ◽  
Martin Petric ◽  
Tim Booth ◽  
Yan Li ◽  
...  
Keyword(s):  
British Columbia ◽  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Human Illness

scholarly journals Intersegmental recombination between the haemagglutinin and matrix genes was responsible for the emergence of a highly pathogenic H7N3 avian influenza virus in British Columbia

2005 ◽  
Vol 86 (3) ◽  
pp. 727-731 ◽  
Author(s):  
John Pasick ◽  
Katherine Handel ◽  
John Robinson ◽  
John Copps ◽  
Deidre Ridd ◽  
...  
Keyword(s):  
British Columbia ◽  
Influenza Virus ◽  
Homologous Recombination ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Highly Pathogenic Avian Influenza ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza ◽  
Pathogenic Viruses ◽  
H7n3 Virus

In February 2004 a highly pathogenic avian influenza (HPAI) outbreak erupted in British Columbia. Investigations indicated that the responsible HPAI H7N3 virus emerged suddenly from a low pathogenic precursor. Analysis of the haemagglutinin (HA) genes of the low and high pathogenic viruses isolated from the index farm revealed the only difference to be a 21 nt insert at the HA cleavage site of the highly pathogenic avian influenza virus. It was deduced that this insert most probably arose as a result of non-homologous recombination between the HA and matrix genes of the same virus. Over the course of the outbreak, a total of 37 isolates with, and 3 isolates without inserts were characterized. The events described here appear very similar to those which occurred in Chile in 2002 where the virulence shift of another H7N3 virus was attributed to non-homologous recombination between the HA and nucleoprotein genes.

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