scholarly journals Incidence and Risk Factors for Immune Reconstitution Inflammatory Syndrome in an Ethnically Diverse HIV Type 1-Infected Cohort

2006 ◽  
Vol 42 (3) ◽  
pp. 418-427 ◽  
Author(s):  
I. Ratnam ◽  
C. Chiu ◽  
N.- B. Kandala ◽  
P. J. Easterbrook
Keyword(s):  
Risk Factors ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Ethnically Diverse ◽  
Hiv Type 1 ◽  
Inflammatory Syndrome

scholarly journals The Epidemiology of IRIS in Southern India: An Observational Cohort Study

2017 ◽  
Vol 16 (5) ◽  
pp. 475-480 ◽  
Author(s):  
Nisha Thambuchetty ◽  
Kayur Mehta ◽  
Karthika Arumugam ◽  
Umadevi G. Shekarappa ◽  
Jyothi Idiculla ◽  
...  
Keyword(s):  
Risk Factors ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
South India ◽  
Significant Risk ◽  
Southern India ◽  
Art Initiation ◽  
Incidence Risk ◽  
Observational Cohort ◽  
Inflammatory Syndrome

Immune reconstitution inflammatory syndrome (IRIS) is an uncommon but dynamic phenomenon seen among patients initiating antiretroviral therapy (ART). We aimed to describe incidence, risk factors, clinical spectrum, and outcomes among ART-naive patients experiencing IRIS in southern India. Among 599 eligible patients monitored prospectively between 2012 and 2014, there were 59.3% males, with mean age 36.6 ± 7.8 years. Immune reconstitution inflammatory syndrome incidence rate was 51.3 per 100 person-years (95% confidence interval: 44.5-59.2). One-third (31.4%) experienced at least 1 IRIS event, at a median of 27 days since ART initiation. Mucocutaneous infections and candidiasis were common IRIS events, followed by tuberculosis. Significant risk factors included age >40 years, body mass index <18.5 kg/m2, CD4 count <100 cells/mm3, viral load >10 000 copies/mL, hemoglobin <11 g/dL, and erythrocyte sedimentation rate >50 mm/h. Immune reconstitution inflammatory syndrome–related morality was 1.3% (8 of 599); 3 patients died of complicated diarrhea. These findings highlight the current spectrum of IRIS in South India and underscore the importance of heightened vigilance for anemia and treatment of diarrhea and candidiasis during ART initiation.

scholarly journals Type 1 Helper T Cells and FoxP3-positive T Cells in HIV–Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome

2008 ◽  
Vol 178 (10) ◽  
pp. 1083-1089 ◽  
Author(s):  
Graeme Meintjes ◽  
Katalin Andrea Wilkinson ◽  
Molebogeng Xheeda Rangaka ◽  
Keira Skolimowska ◽  
Kerryn van Veen ◽  
...  
Keyword(s):  
T Cells ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Helper T Cells ◽  
Inflammatory Syndrome

scholarly journals Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Tasnim M. Bana ◽  
Maia Lesosky ◽  
Dominique J. Pepper ◽  
Helen van der Plas ◽  
Charlotte Schutz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Immune Reconstitution Inflammatory Syndrome ◽  
Immune Reconstitution ◽  
Inflammatory Syndrome
Sign in / Sign up

Export Citation Format

Share Document