scholarly journals The Acute‐Phase Response and Serum Amyloid A Inhibit the Inflammatory Response toAcinetobacter baumanniiPneumonia

2006 ◽  
Vol 193 (2) ◽  
pp. 187-195 ◽  
Author(s):  
Rosemarijn Renckens ◽  
Joris J. T. H. Roelofs ◽  
Sylvia Knapp ◽  
Alex F. de Vos ◽  
Sandrine Florquin ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Serum Amyloid A ◽  
Phase Response ◽  
Serum Amyloid ◽  
Amyloid A

The acute phase response and C-reactive protein

2020 ◽  
pp. 2199-2207
Author(s):  
Mark B. Pepys
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Serum Amyloid A ◽  
Acute Phase Proteins ◽  
Phase Response ◽  
Serum Amyloid ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Amyloid A ◽  
Serum Amyloid A Protein

The acute phase response—trauma, tissue necrosis, infection, inflammation, and malignant neoplasia induce a complex series of nonspecific systemic, physiological, and metabolic responses including fever, leucocytosis, catabolism of muscle proteins, greatly increased de novo synthesis and secretion of a number of ‘acute phase’ plasma proteins, and decreased synthesis of albumin, transthyretin, and high- and low-density lipoproteins. The altered plasma protein concentration profile is called the acute phase response. Acute phase proteins—these are mostly synthesized by hepatocytes, in which transcription is controlled by cytokines including interleukin 1, interleukin 6, and tumour necrosis factor. The circulating concentrations of complement proteins and clotting factors increase by up to 50 to 100%; some of the proteinase inhibitors and α‎1-acid glycoprotein can increase three- to fivefold; but C-reactive protein (CRP) and serum amyloid A protein (an apolipoprotein of high-density lipoprotein particles) are unique in that their concentrations can change by more than 1000-fold. C-reactive protein—this consists of five identical, nonglycosylated, noncovalently associated polypeptide subunits. It binds to autologous and extrinsic materials which contain phosphocholine, including bacteria and their products. Ligand-bound CRP activates the classical complement pathway and triggers the inflammatory and opsonizing activities of the complement system, thereby contributing to innate host resistance to pneumococci and probably to recognition and safe ‘scavenging’ of cellular debris. Clinical features—(1) determination of CRP in serum or plasma is the most useful marker of the acute phase response in most inflammatory and tissue damaging conditions. (2) Acute phase proteins may be harmful in some circumstances. Sustained increased production of serum amyloid A protein can lead to the deposition of AA-type, reactive systemic amyloid.

Serum amyloid A and high density lipoproteins during the acute phase response

1988 ◽  
Vol 18 (6) ◽  
pp. 619-626 ◽  
Author(s):  
LINDA L. BAUSSERMAN ◽  
D. N. BERNIER ◽  
K. P. W. J. McADAM ◽  
P. N. HERBERT
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Serum Amyloid A ◽  
High Density ◽  
Phase Response ◽  
Serum Amyloid ◽  
High Density Lipoproteins ◽  
Amyloid A

scholarly journals Acute phase response in the primiparous dairy cows after repeated percutaneous liver biopsy during the transition period

2016 ◽  
Vol 19 (2) ◽  
pp. 393-399 ◽  
Author(s):  
P. Jawor ◽  
A. Brzozowska ◽  
K. Słoniewski ◽  
Z.M. Kowalski ◽  
T. Stefaniak
Keyword(s):  
Body Temperature ◽  
Liver Biopsy ◽  
Dairy Cows ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Serum Amyloid A ◽  
Transition Period ◽  
Phase Response ◽  
Serum Amyloid ◽  
Amyloid A

Abstract The aim of this study was to evaluate the acute phase response of dairy cows to repeated liver biopsy in order to estimate the safety of this procedure during the transition period. Liver biopsies (up to 1000 mg of liver tissue) were conducted twice a day, 7 days before expected parturition and 3 days after calving. The number of needle insertions for each biopsy was recorded and was dependent on the amount of obtained tissue. Blood samples were taken on day 7 before expected parturition, then on days 3, 4, 7 and 14 after calving. Body temperature was measured daily in all 30 cows from day 3 until day 14 after calving. The concentrations of haptoglobin, serum amyloid A, fibrinogen and interleukin-6 were determined in serum and plasma. In 16.7% of cows, the rectal body temperature rose by ≥ 0.5°C on the day after liver biopsy. Although the concentrations of haptoglobin, serum amyloid A and fibrinogen increased significantly after calving (p<0.01), there was no influence of the number of biopsies on the acute phase reaction and repeated biopsy during the transition period had no effect on body temperature. Therefore, the procedure may be regarded as safe for cows during the transition period.

The acute phase response in Syrian hamsters elevates apolipoprotein serum amyloid A (apoSAA) and disrupts lipoprotein metabolism

Amyloid ◽  
1996 ◽  
Vol 3 (4) ◽  
pp. 261-269 ◽  
Author(s):  
Wayne A. Gonnerman ◽  
May Lima ◽  
Jean D. Sipe ◽  
Kenneth C. Hayes ◽  
Edgar S. Cathcart
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Serum Amyloid A ◽  
Lipoprotein Metabolism ◽  
Phase Response ◽  
Serum Amyloid ◽  
Syrian Hamsters ◽  
Amyloid A

Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain

1997 ◽  
Vol 225 (2) ◽  
pp. 73-76 ◽  
Author(s):  
Jun-shan Liang ◽  
Jacob A Sloane ◽  
John M Wells ◽  
Carmela R Abraham ◽  
Richard E Fine ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Serum Amyloid A ◽  
Phase Response ◽  
Serum Amyloid ◽  
Local Production ◽  
Amyloid A

scholarly journals Zinc Regulates the Acute Phase Response and Serum Amyloid A Production in Response to Sepsis through JAK-STAT3 Signaling

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94934 ◽  
Author(s):  
Ming-Jie Liu ◽  
Shengying Bao ◽  
Jessica R. Napolitano ◽  
Dara L. Burris ◽  
Lianbo Yu ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Serum Amyloid A ◽  
Phase Response ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Stat3 Signaling
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