scholarly journals Outcome of Prosthetic Joint Infection in Patients with Rheumatoid Arthritis: The Impact of Medical and Surgical Therapy in 200 Episodes

2006 ◽  
Vol 42 (2) ◽  
pp. 216-223 ◽  
Author(s):  
E. F. Berbari ◽  
D. R. Osmon ◽  
M. C. T. Duffy ◽  
R. N. W. Harmssen ◽  
J. N. Mandrekar ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Surgical Therapy ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Prosthetic Joint ◽  
The Impact

Assessing risk of prosthetic joint infection

2018 ◽  
pp. 9-12
Author(s):  
Umraz Khan ◽  
Graeme Perks ◽  
Rhidian Morgan-Jones ◽  
Peter James ◽  
Colin Esler ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
High Risk ◽  
Prosthetic Joint Infection ◽  
Elective Surgery ◽  
Joint Infection ◽  
High Risk Patient ◽  
Prosthetic Joint ◽  
Risk Patients ◽  
Marginal Gain ◽  
Cellular Turnover

This chapter discusses assessing the risk of prosthetic joint infection (PJI) and includes discussion on high-risk patients (classified by age, skin colour, extracellular matrix, cellular turnover, diabetes, obesity, rheumatoid arthritis, previous periarticular fractures and skin disorders). The aim is to allow the practitioner to identify high-risk patient attributes that can be positively influenced such that the risk of PJI is reduced. There are some patients with more than one risk factor and, as such, every effort must be made to reduce each even if there is a marginal gain in each. Delaying elective surgery until the risks of PJI are reduced must be encouraged but must be balanced with alleviating patient symptoms.

scholarly journals Risk of Recurrent Staphylococcus aureus Prosthetic Joint Infection in Rheumatoid Arthritis Patients—A Nationwide Cohort Study

2019 ◽  
Vol 6 (11) ◽  
Author(s):  
Namrata Singh ◽  
Rajeshwari Nair ◽  
Michihiko Goto ◽  
Martha L Carvour ◽  
Ryan Carnahan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Staphylococcus Aureus ◽  
Cohort Study ◽  
Prosthetic Joint Infection ◽  
Proportional Hazards ◽  
Joint Infection ◽  
International Classification Of Diseases ◽  
Cox Proportional Hazards ◽  
Prosthetic Joint ◽  
Implant Retention

AbstractBackgroundTreatment of rheumatoid arthritis (RA) often involves immune-suppressive therapies. Concern for recurrent prosthetic joint infection (PJI) in RA patients might be high and could reduce use of joint implantation in these patients. We aimed to evaluate the risk of recurrence of PJI in RA patients compared with osteoarthritis (OA) patients by utilizing a large health care system.MethodsWe conducted a retrospective cohort study of all patients admitted for a Staphylococcus aureus PJI who underwent debridement, antibiotics, and implant retention (DAIR) or 2-stage exchange (2SE) between 2003 and 2010 at 86 Veterans Affairs Medical Centers. Both RA patients and the comparison group of osteoarthritis (OA) patients were identified using International Classification of Diseases, Ninth Revision, codes. All index PJI and recurrent positive cultures for S. aureus during 2 years of follow-up were validated by manual chart review. A Cox proportional hazards regression model was used to compare the time to recurrent PJI for RA vs OA.ResultsIn our final cohort of 374 veterans who had either DAIR or 2SE surgery for their index S. aureus PJI, 11.2% had RA (n = 42). The majority of the cohort was male (97.3%), and 223 (59.6%) had a methicillin-susceptible S. aureus PJI. RA patients had a similar risk of failure compared with OA patients, after adjusting for covariates (hazard ratio, 0.81; 95% confidence interval, 0.48–1.37).ConclusionsPrior diagnosis of RA does not increase the risk of recurrent S. aureus PJI. Further studies are needed to evaluate the effect of different RA therapies on outcomes of episodes of PJI.

scholarly journals Impact of Prior Intra-articular Injections on the Risk of Prosthetic Joint Infection Following Total Joint Arthroplasty: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Fei Nie ◽  
Wei Li
Keyword(s):  
Systematic Review ◽  
Prosthetic Joint Infection ◽  
Total Joint Arthroplasty ◽  
Meta Analysis ◽  
Joint Infection ◽  
Joint Arthroplasty ◽  
Injection Group ◽  
Prosthetic Joint ◽  
Increased Risk ◽  
The Impact

Objective: The current review was designed to assess the impact of prior intra-articular injections on the risk of prosthetic joint infection (PJI) in patients undergoing total joint arthroplasty (TJA) with a focus on the timing of injection before surgery.Methods: The databases of PubMed, Embase and Google Scholar were searched up to 15th June 2021. All studies comparing the incidence of PJI with and without prior intra-articular injections were included. Risk ratios (RR) with 95% confidence intervals were calculated for PJI.Results: Nineteen studies were included. Both corticosteroids and hyaluronic acid injections were used before TJA in the included studies. Overall, comparing 127,163 patients with prior intra-articular injections and 394,104 patients without any injections, we noted a statistically significant increased risk of PJI in the injection group (RR 1.24 95% CI: 1.11, 1.38 I2 = 48% p = 0.002). On subgroup analysis, there was a statistically significant increased risk of PJI in the injection group in studies where intra-articular injections were administered <12 months before surgery (RR 1.18 95% CI: 1.10, 1.27 I2 = 7% p < 0.00001). Furthermore, on meta-analysis, we noted non-significant but increased risk of PJI when injections were administered 1 month (RR 1.47 95% CI: 0.88, 2.46 I2 = 77% p = 0.14), 0–3 months (RR 1.22 95% CI: 0.96, 1.56 I2 = 84% p = 0.11), and 3–6 months (RR 1.16 95% CI: 0.99, 1.35 I2 = 49% p = 0.06) before surgery.Conclusion: Our results indicate that patients with prior intra-articular injections have a small but statistically significant increased risk of PJI after TJA. Considering that PJI is a catastrophic complication with huge financial burden, morbidity and mortality; the clinical significance of this small risk cannot be dismissed. The question of the timing of injections and the risk of PJI still remains and can have a significant impact on the decision making.Systematic Review Registration: PROSPERO: CRD42021258297.

scholarly journals Deep prosthetic joint infection: a qualitative study of the impact on patients and their experiences of revision surgery

BMJ Open ◽  
2015 ◽  
Vol 5 (12) ◽  
pp. e009495 ◽  
Author(s):  
Andrew J Moore ◽  
Ashley W Blom ◽  
Michael R Whitehouse ◽  
Rachael Gooberman-Hill
Keyword(s):  
Qualitative Study ◽  
Prosthetic Joint Infection ◽  
Revision Surgery ◽  
Joint Infection ◽  
Prosthetic Joint ◽  
The Impact

scholarly journals Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis

2008 ◽  
Vol 59 (12) ◽  
pp. 1713-1720 ◽  
Author(s):  
Tim Bongartz ◽  
Christine S. Halligan ◽  
Douglas R. Osmon ◽  
Megan S. Reinalda ◽  
William R. Bamlet ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Knee Replacement ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Total Hip ◽  
Prosthetic Joint

Anti-tumor necrosis factor therapy in rheumatoid arthritis patients with a history of deep prosthetic joint infection: a report of four cases

2011 ◽  
Vol 21 (5) ◽  
pp. 542-547
Author(s):  
Yuji Hirano ◽  
Toshihisa Kojima ◽  
Yasuhide Kanayama ◽  
Tomone Shioura ◽  
Masatoshi Hayashi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis Factor ◽  
Prosthetic Joint Infection ◽  
Tumor Necrosis ◽  
Joint Infection ◽  
Prosthetic Joint ◽  
History Of ◽  
Factor Therapy ◽  
Necrosis Factor
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