scholarly journals Acid and Bile‐Salt Stress of EnteropathogenicEscherichia coliEnhances Adhesion to Epithelial Cells and Alters Glycolipid Receptor Binding Specificity

2005 ◽  
Vol 192 (8) ◽  
pp. 1430-1440 ◽  
Author(s):  
Margaret C. de Jesus ◽  
Agnieszka A. Urban ◽  
Marastella E. Marasigan ◽  
Debora E. Barnett Foster
Keyword(s):  
Salt Stress ◽  
Epithelial Cells ◽  
Bile Salt ◽  
Receptor Binding ◽  
Binding Specificity ◽  
Receptor Binding Specificity ◽  
Glycolipid Receptor

High-Resolution Structure of Murine Interleukin 1 Homologue IL-1F5 Reveals Unique Loop Conformations for Receptor Binding Specificity†,‡

Biochemistry ◽  
2003 ◽  
Vol 42 (37) ◽  
pp. 10938-10944 ◽  
Author(s):  
Eleanor F. Dunn ◽  
Nicholas J. Gay ◽  
Adrian F. Bristow ◽  
David P. Gearing ◽  
Luke A. J. O'Neill ◽  
...  
Keyword(s):  
High Resolution ◽  
Receptor Binding ◽  
Interleukin 1 ◽  
Binding Specificity ◽  
Loop Conformations ◽  
High Resolution Structure ◽  
Receptor Binding Specificity ◽  
Resolution Structure

scholarly journals Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity

2017 ◽  
Vol 23 (2) ◽  
pp. 220-231 ◽  
Author(s):  
Hongbo Guo ◽  
Erik de Vries ◽  
Ryan McBride ◽  
Jojanneke Dekkers ◽  
Wenjie Peng ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Influenza A ◽  
Binding Specificity ◽  
Highly Pathogenic ◽  
Receptor Binding Specificity

scholarly journals Receptor-Binding Specificity Depending on N-terminal Structure of VIP/PACAP

1999 ◽  
Vol 20 (4) ◽  
pp. 219-231 ◽  
Author(s):  
SATOMI ONOUE ◽  
YUMIKO NAGANO ◽  
ICHIRO TATSUNO ◽  
DAIGAKU UCHIDA ◽  
KAZUHISA KASHIMOTO
Keyword(s):  
Receptor Binding ◽  
Binding Specificity ◽  
Terminal Structure ◽  
Receptor Binding Specificity

scholarly journals Neuraminidase Inhibitor Sensitivity and Receptor-Binding Specificity of Cambodian Clade 1 Highly Pathogenic H5N1 Influenza Virus

2011 ◽  
Vol 55 (5) ◽  
pp. 2004-2010 ◽  
Author(s):  
M. Naughtin ◽  
J. C. Dyason ◽  
S. Mardy ◽  
S. Sorn ◽  
M. von Itzstein ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Receptor Binding ◽  
Reverse Genetics ◽  
Binding Specificity ◽  
Neuraminidase Inhibitor ◽  
H5n1 Influenza Virus ◽  
Highly Pathogenic ◽  
H5n1 Influenza ◽  
Receptor Binding Specificity ◽  
Pathogenic H5n1

ABSTRACTThe evolution of the highly pathogenic H5N1 influenza virus produces genetic variations that can lead to changes in antiviral susceptibility and in receptor-binding specificity. In countries where the highly pathogenic H5N1 virus is endemic or causes regular epidemics, the surveillance of these changes is important for assessing the pandemic risk. In Cambodia between 2004 and 2010, there have been 26 outbreaks of highly pathogenic H5N1 influenza virus in poultry and 10 reported human cases, 8 of which were fatal. We have observed naturally occurring mutations in hemagglutinin (HA) and neuraminidase (NA) of Cambodian H5N1 viruses that were predicted to alter sensitivity to neuraminidase inhibitors (NAIs) and/or receptor-binding specificity. We tested H5N1 viruses isolated from poultry and humans between 2004 and 2010 for sensitivity to the NAIs oseltamivir (Tamiflu) and zanamivir (Relenza). All viruses were sensitive to both inhibitors; however, we identified a virus with a mildly decreased sensitivity to zanamivir and have predicted that a V149A mutation is responsible. We also identified a virus with a hemagglutinin A134V mutation, present in a subpopulation amplified directly from a human sample. Using reverse genetics, we verified that this mutation is adaptative for human α2,6-linked sialidase receptors. The importance of an ongoing surveillance of H5N1 antigenic variance and genetic drift that may alter receptor binding and sensitivities of H5N1 viruses to NAIs cannot be underestimated while avian influenza remains a pandemic threat.

Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity

Nature ◽  
1983 ◽  
Vol 304 (5921) ◽  
pp. 76-78 ◽  
Author(s):  
G. N. Rogers ◽  
J. C. Paulson ◽  
R. S. Daniels ◽  
J. J. Skehel ◽  
I. A. Wilson ◽  
...  
Keyword(s):  
Amino Acid ◽  
Receptor Binding ◽  
Binding Specificity ◽  
Single Amino Acid ◽  
Amino Acid Substitutions ◽  
Receptor Binding Specificity
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