scholarly journals In Vivo Development of High-Level Fluoroquinolone Resistance in Streptococcus pneumoniae in Chronic Obstructive Pulmonary Disease

2005 ◽  
Vol 41 (4) ◽  
pp. 560-564 ◽  
Author(s):  
E. Purez-Trallero ◽  
J. M. Marimon ◽  
A. Gonzalez ◽  
M. Ercibengoa ◽  
J. Larruskain
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Streptococcus Pneumoniae ◽  
Pulmonary Disease ◽  
Fluoroquinolone Resistance ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
High Level

In Vivo Thrombin Generation and Platelet Hyperactivity in Patients with Chronic Obstructive Pulmonary Disease

Platelets ◽  
1994 ◽  
Vol 5 (5) ◽  
pp. 276-278 ◽  
Author(s):  
P. Ferroni ◽  
S. Basili ◽  
F. M. Pulcinelli ◽  
G. Pettirossi ◽  
C. Alessandri ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Thrombin Generation ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Repeated Exposure to Streptococcus pneumoniae Exacerbates Chronic Obstructive Pulmonary Disease

2019 ◽  
Vol 189 (9) ◽  
pp. 1711-1720 ◽  
Author(s):  
Xuxu Gou ◽  
Qiao Zhang ◽  
Sunil More ◽  
Gayan Bamunuarachchi ◽  
Yurong Liang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Streptococcus Pneumoniae ◽  
Pulmonary Disease ◽  
Repeated Exposure ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Chemerin: A Potential Regulator of Inflammation and Metabolism for Chronic Obstructive Pulmonary Disease and Pulmonary Rehabilitation

2020 ◽  
Vol 2020 ◽  
pp. 1-20
Author(s):  
Jian Li ◽  
Yufan Lu ◽  
Ning Li ◽  
Peijun Li ◽  
Zhengrong Wang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lipid Metabolism ◽  
Pulmonary Disease ◽  
Inflammatory Responses ◽  
Therapeutic Interventions ◽  
Chronic Obstructive ◽  
Barrier Dysfunction ◽  
Obstructive Pulmonary Disease ◽  
Glucose And Lipid Metabolism

Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are also closely related to inflammation processes. Further insights into the interactions of inflammation and glucose and lipid metabolism might therefore inspire novel therapeutic interventions to promote lung rehabilitation. Chemerin, as a recently discovered adipokine, has been shown to play a role in inflammatory response and glucose and lipid metabolism in many diseases (including COPD). Chemerin recruits inflammatory cells to sites of inflammation during the early stages of COPD, leading to endothelial barrier dysfunction, early vascular remodeling, and angiogenesis. Moreover, it supports the recruitment of antigen-presenting cells that guide immune cells as part of the body’s inflammatory responses. Chemerin also regulates metabolism via activation of its cognate receptors. Glucose homeostasis is affected via effects on insulin secretion and sensitivity, and lipid metabolism is changed by increased transformation of preadipocytes to mature adipocytes through chemerin-binding receptors. Controlling chemerin signaling may be a promising approach to improve various aspects of COPD-related dysfunction. Importantly, several studies indicate that chemerin expression in vivo is influenced by exercise. Although available evidence is still limited, therapeutic alterations of chemerin activity may be a promising target of therapeutic approaches aimed at the rehabilitation of COPD patients based on exercises. In conclusion, chemerin plays an essential role in COPD, especially in the inflammatory responses and metabolism, and has a potential to become a target for, and a biomarker of, curative mechanisms underlying exercise-mediated lung rehabilitation.

scholarly journals Imaging approaches to understand disease complexity: chronic obstructive pulmonary disease as a clinical model

2018 ◽  
Vol 124 (2) ◽  
pp. 512-520 ◽  
Author(s):  
Karin J. C. Sanders ◽  
Samuel Y. Ash ◽  
George R. Washko ◽  
Felix M. Mottaghy ◽  
Annemie M. W. J. Schols
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Medical Imaging ◽  
Pulmonary Disease ◽  
Clinical Care ◽  
Clinical Manifestations ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Clinical Model ◽  
Imaging Research

The clinical manifestations of chronic obstructive pulmonary disease (COPD) reflect an aggregate of multiple pulmonary and extrapulmonary processes. It is increasingly clear that full assessment of these processes is essential to characterize disease burden and to tailor therapy. Medical imaging has advanced such that it is now possible to obtain in vivo insight in the presence and severity of lung disease-associated features. In this review, we have assembled data from multiple disciplines of medical imaging research to review the role of imaging in characterization of COPD. Topics include imaging of the lungs, body composition, and extrapulmonary tissue metabolism. The primary focus is on imaging modalities that are widely available in clinical care settings and that potentially contribute to describing COPD heterogeneity and enhance our insight in underlying pathophysiological processes and their structural and functional effects.

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