scholarly journals Highly Bovine Spongiform Encephalopathy–Sensitive Transgenic Mice Confirm the Essential Restriction of Infectivity to the Nervous System in Clinically Diseased Cattle

2005 ◽  
Vol 192 (5) ◽  
pp. 934-942 ◽  
Author(s):  
Anne Buschmann ◽  
Martin H. Groschup
Keyword(s):  
Nervous System ◽  
Transgenic Mice ◽  
Bovine Spongiform Encephalopathy ◽  
Spongiform Encephalopathy ◽  
Essential Restriction

Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice

2002 ◽  
Vol 20 (11) ◽  
pp. 1147-1150 ◽  
Author(s):  
Jiri G. Safar ◽  
Michael Scott ◽  
Jeff Monaghan ◽  
Camille Deering ◽  
Svetlana Didorenko ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Bovine Spongiform Encephalopathy ◽  
Chronic Wasting Disease ◽  
Spongiform Encephalopathy ◽  
Wasting Disease

scholarly journals Experimental Transmission of H-Type Bovine Spongiform Encephalopathy to Bovinized Transgenic Mice

2010 ◽  
Vol 48 (5) ◽  
pp. 942-947 ◽  
Author(s):  
H. Okada ◽  
K. Masujin ◽  
Y. Iwamaru ◽  
M. Imamura ◽  
Y. Matsuura ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Bovine Spongiform Encephalopathy ◽  
Spongiform Encephalopathy ◽  
Experimental Transmission

scholarly journals Protease-resistant PrP deposition in brain and non-central nervous system tissues of a murine model of bovine spongiform encephalopathy

1996 ◽  
Vol 77 (8) ◽  
pp. 1941-1946 ◽  
Author(s):  
C. F. Farquhar ◽  
J. Dornan ◽  
R. C. Moore ◽  
R. A. Somerville ◽  
A. M. Tunstall ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Bovine Spongiform Encephalopathy ◽  
Murine Model ◽  
Spongiform Encephalopathy

scholarly journals PrPTSE in muscle-associated lymphatic tissue during the preclinical stage of mice infected orally with bovine spongiform encephalopathy

2009 ◽  
Vol 90 (10) ◽  
pp. 2563-2568 ◽  
Author(s):  
Franco Cardone ◽  
Achim Thomzig ◽  
Walter Schulz-Schaeffer ◽  
Angelina Valanzano ◽  
Marco Sbriccoli ◽  
...  
Keyword(s):  
Nervous System ◽  
Bovine Spongiform Encephalopathy ◽  
Neuromuscular Junctions ◽  
Clinical Stage ◽  
Transmissible Spongiform Encephalopathies ◽  
Spongiform Encephalopathy ◽  
Muscle Fibres ◽  
Preclinical Stage ◽  
Spongiform Encephalopathies ◽  
Stage Of Disease

The involvement of muscles in the pathogenesis of transmissible spongiform encephalopathies (TSEs) is irregular and unpredictable. We show that the TSE-specific protein (PrPTSE) is present in muscles of mice fed with a mouse-adapted strain of bovine spongiform encephalopathy as early as 100 days post-infection, corresponding to about one-third of the incubation period. The proportion of mice with PrPTSE-positive muscles and the number of muscles involved increased as infection progressed, but never attained more than a limited distribution, even at the clinical stage of disease. The appearance of PrPTSE in muscles during the preclinical stage of disease was probably due to the haematogenous/lymphatic spread of infectivity from the gastrointestinal tract to lymphatic tissues associated with muscles, whereas in symptomatic animals, the presence of PrPTSE in the nervous system, in neuromuscular junctions and in muscle fibres suggests a centrifugal spread from the central nervous system, as already observed in other TSE models.

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