scholarly journals A Retrospective, Case-Control Study of Acyclovir Resistance in Herpes Simplex Virus

2005 ◽  
Vol 41 (3) ◽  
pp. 320-326 ◽  
Author(s):  
D. Malvy ◽  
M. Treilhaud ◽  
S. Bouee ◽  
A. Crochard ◽  
D. Vallee ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Case Control Study ◽  
Case Control ◽  
Retrospective Case ◽  
Simplex Virus ◽  
Control Study

scholarly journals Results From a Hypothesis Generating Case-Control Study: Herpes Family Viruses and Schizophrenia Among Military Personnel

2007 ◽  
Vol 34 (6) ◽  
pp. 1182-1188 ◽  
Author(s):  
David W. Niebuhr ◽  
Amy M. Millikan ◽  
Robert Yolken ◽  
Yuanzhang Li ◽  
Natalya S. Weber
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Case Control Study ◽  
Case Control ◽  
Herpes Viruses ◽  
Herpès Virus ◽  
Simplex Virus ◽  
Control Study

Abstract Background: Herpes family viruses can cause central nervous system inflammatory changes that can present with symptoms indistinguishable from schizophrenia and therefore are of interest in schizophrenia research. Most existing studies of herpes viruses have used small populations and postdiagnosis specimens. As part of a larger research program, we conducted a hypothesis-generating case-control study of selected herpes virus antibodies among individuals discharged from the US military with schizophrenia and pre- and postdiagnosis sera. Methods: Cases (n = 180) were servicemembers hospitalized and discharged from military service with schizophrenia. Controls, 3:1 matched on several factors, were members not discharged. The military routinely collects and stores members' serum specimens. We used microplate enzyme immunoassay to measure immunoglobulin G (IgG) antibody levels to 6 herpes viruses in pre- and postdiagnosis specimens. Conditional logistic regression was used, and the measure of association was the hazard ratio (HR). Results: Overall, we found a significant association between human herpes virus type 6 and schizophrenia, with an HR of 1.17 (95% confidence interval [CI] = 1.04, 1.32). Women and blacks had significant negative associations with herpes simplex virus type 2 and cytomegalovirus; among blacks, there was a significant positive association with herpes simplex virus type 1. Among men, there was a HHV-6 temporal effect with an HR of 1.41 (95% CI = 1.02, 1.96) for sera drawn 6–12 months before diagnosis. Discussion: Findings from previous studies of herpes family viruses and schizophrenia have been inconsistent. Our study is based on a larger population than most previous studies and used serum specimens collected before onset of illness. This study adds to the body of knowledge and provides testable hypotheses for follow-on studies.

Maternal Herpes simplex virus type 2 infection, syphilis and risk of intra-partum transmission of HIV-1: results of a case control study

AIDS ◽  
2008 ◽  
Vol 22 (2) ◽  
pp. 193-201 ◽  
Author(s):  
Frances M Cowan ◽  
Jean H Humphrey ◽  
Robert Ntozini ◽  
Kuda Mutasa ◽  
Rhoda Morrow ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Case Control Study ◽  
Case Control ◽  
Simplex Virus ◽  
Hiv 1 ◽  
Control Study
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