scholarly journals An Animal Model for the Tickborne Flavivirus—Omsk Hemorrhagic Fever Virus

2005 ◽  
Vol 191 (1) ◽  
pp. 100-108 ◽  
Author(s):  
Michael R. Holbrook ◽  
Judith F. Aronson ◽  
Gerald A. Campbell ◽  
Steven Jones ◽  
Heinz Feldmann ◽  
...  
Keyword(s):  
Animal Model ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Hemorrhagic Fever Virus ◽  
Omsk Hemorrhagic Fever

scholarly journals Pathogenesis and Immune Response of Crimean-Congo Hemorrhagic Fever Virus in a STAT-1 Knockout Mouse Model

2010 ◽  
Vol 84 (21) ◽  
pp. 11089-11100 ◽  
Author(s):  
Dennis A. Bente ◽  
Judie B. Alimonti ◽  
Wun-Ju Shieh ◽  
Gaëlle Camus ◽  
Ute Ströher ◽  
...  
Keyword(s):  
Animal Model ◽  
Mouse Model ◽  
Immune Cell ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Interferon Response ◽  
Laboratory Animals ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus ◽  
Elevated Liver Enzymes

ABSTRACT Tick-borne Crimean-Congo hemorrhagic fever virus (CCHFV) causes a severe hemorrhagic syndrome in humans but not in its vertebrate animal hosts. The pathogenesis of the disease is largely not understood due to the lack of an animal model. Laboratory animals typically show no overt signs of disease. Here, we describe a new small-animal model to study CCHFV pathogenesis that manifests clinical disease, similar to that seen in humans, without adaptation of the virus to the host. Our studies revealed that mice deficient in the STAT-1 signaling molecule were highly susceptible to infection, succumbing within 3 to 5 days. After CCHFV challenge, mice exhibited fever, leukopenia, thrombocytopenia, and highly elevated liver enzymes. Rapid viremic dissemination and extensive replication in visceral organs, mainly in liver and spleen, were associated with prominent histopathologic changes in these organs. Dramatically elevated proinflammatory cytokine levels were detected in the blood of the animals, suggestive of a cytokine storm. Immunologic analysis revealed delayed immune cell activation and intensive lymphocyte depletion. Furthermore, this study also demonstrated that ribavirin, a suggested treatment in human cases, protects mice from lethal CCHFV challenge. In conclusion, our data demonstrate that the interferon response is crucial in controlling CCHFV replication in this model, and this is the first study that offers an in-depth in vivo analysis of CCHFV pathophysiology. This new mouse model exhibits key features of fatal human CCHF, proves useful for the testing of therapeutic strategies, and can be used to study virus attenuation.

Inactivated Vaccine Against Tick-Borne Encephalitis Virus as Surrogate Vaccine Against Omsk Hemorrhagic Fever Virus

2011 ◽  
Vol 90 (2) ◽  
pp. A45 ◽  
Author(s):  
Liubov Terekhina ◽  
Nataliya Pripuzova ◽  
Mikhail Vorovitch ◽  
Yulia Rogova ◽  
Lidiya Romanova ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Encephalitis Virus ◽  
Fever Virus ◽  
Inactivated Vaccine ◽  
Hemorrhagic Fever Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Omsk Hemorrhagic Fever

scholarly journals Trans Complementation of Replication-defective Omsk Hemorrhagic Fever Virus for Antiviral Study

2019 ◽  
Vol 34 (4) ◽  
pp. 412-422 ◽  
Author(s):  
Qiuyan Zhang ◽  
Na Li ◽  
Chenglin Deng ◽  
Zherui Zhang ◽  
Xiaodan Li ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Hemorrhagic Fever Virus ◽  
Omsk Hemorrhagic Fever

scholarly journals Structure of the envelope protein domain III of Omsk hemorrhagic fever virus

Virology ◽  
2006 ◽  
Vol 351 (1) ◽  
pp. 188-195 ◽  
Author(s):  
David E. Volk ◽  
Leonard Chavez ◽  
David W.C. Beasley ◽  
Alan D.T. Barrett ◽  
Michael R. Holbrook ◽  
...  
Keyword(s):  
Envelope Protein ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Protein Domain ◽  
Hemorrhagic Fever Virus ◽  
Domain Iii ◽  
Omsk Hemorrhagic Fever

scholarly journals Construction of an infectious cDNA clone for Omsk hemorrhagic fever virus, and characterization of mutations in NS2A and NS5

2011 ◽  
Vol 155 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Kentaro Yoshii ◽  
Manabu Igarashi ◽  
Kimihito Ito ◽  
Hiroaki Kariwa ◽  
Michael R. Holbrook ◽  
...  
Keyword(s):  
Cdna Clone ◽  
Hemorrhagic Fever ◽  
Infectious Cdna Clone ◽  
Fever Virus ◽  
Hemorrhagic Fever Virus ◽  
Omsk Hemorrhagic Fever

The deduced evolution history of Omsk hemorrhagic fever virus

2013 ◽  
Vol 86 (7) ◽  
pp. 1181-1187 ◽  
Author(s):  
Liudmila S. Karan ◽  
Massimo Ciccozzi ◽  
Valerii V. Yakimenko ◽  
Alessandra Lo Presti ◽  
Eleonora Cella ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Hemorrhagic Fever Virus ◽  
History Of ◽  
Omsk Hemorrhagic Fever
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