scholarly journals Inhibition of Heme Aggregation by Chloroquine ReducesSchistosoma mansoniInfection

2004 ◽  
Vol 190 (4) ◽  
pp. 843-852 ◽  
Author(s):  
Marcus F. Oliveira ◽  
Joana C. P. d'Avila ◽  
Antônio J. Tempone ◽  
Juliana B. R. Corrêa Soares ◽  
Franklin D. Rumjanek ◽  
...  
Keyword(s):  
Heme Aggregation

Raman microspectroscopy and imaging provides insights into heme aggregation and denaturation within human erythrocytes

2005 ◽  
Vol 10 (1) ◽  
pp. 014005 ◽  
Author(s):  
Bayden R. Wood ◽  
Larissa Hammer ◽  
Lara Davis ◽  
Don McNaughton
Keyword(s):  
Raman Microspectroscopy ◽  
Human Erythrocytes ◽  
Heme Aggregation

scholarly journals Effect of Red Light-Emitting Diodes Irradiation on Hemoglobin for Potential Hypertension Treatment Based on Confocal Micro-Raman Spectroscopy

Scanning ◽  
2017 ◽  
Vol 2017 ◽  
pp. 1-8
Author(s):  
Xuejun Qiu ◽  
Hanchuan Huang ◽  
Zhitong Huang ◽  
Zhengfei Zhuang ◽  
Zhouyi Guo ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Raman Spectra ◽  
Light Emitting Diodes ◽  
Red Light ◽  
Oxygen Binding ◽  
Dependent Manner ◽  
Light Emitting ◽  
Micro Raman Spectroscopy ◽  
Heme Aggregation ◽  
Led Irradiation

Red light-emitting diodes (LED) were used to irradiate the isolated hypertension hemoglobin (Hb) and Raman spectra difference was recorded using confocal micro-Raman spectroscopy. Differences were observed between the controlled and irradiated Hb by comparing the spectra records. The Raman spectrum at the 1399 cm−1 band decreased following prolonged LED irradiation. The intensity of the 1639 cm−1 band decreased dramatically in the first five minutes and then gradually increased in a time-dependent manner. This observation indicated that LED irradiation increased the ability of oxygen binding in Hb. The appearance of the heme aggregation band at 1399 cm−1, in addition to the oxygen marker band at 1639 cm−1, indicated that, in our study, 30 min of irradiation with 15.0 mW was suitable for inhibiting heme aggregation and enhancing the oxygen-carrying capacity of Hb. Principal component analysis showed a one-to-one relationship between irradiated Hb at different time points and the corresponding Raman spectra. Our approach could be used to analyze the hemoglobin from patients with confocal micro-Raman spectroscopy and is helpful for developing new nondrug hypertension therapy.

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