scholarly journals CD4 Cell Response to 3 Doses of Subcutaneous Interleukin 2: Meta-analysis of 3 Vanguard Studies

2004 ◽  
Vol 39 (1) ◽  
pp. 115-122 ◽  
Author(s):  
R. C. Arduino ◽  
E. C. Nannini ◽  
M. R. Barradas ◽  
S. Schrader ◽  
M. Losso ◽  
...  
2018 ◽  
Vol 66 (suppl_2) ◽  
pp. S152-S159 ◽  
Author(s):  
Nathan Ford ◽  
Zara Shubber ◽  
Joseph N Jarvis ◽  
Tom Chiller ◽  
Greg Greene ◽  
...  

2010 ◽  
Vol 84 (20) ◽  
pp. 10923-10927 ◽  
Author(s):  
Michael Molloy ◽  
Weijun Zhang ◽  
Edward Usherwood

ABSTRACT Interleukin-2 (IL-2) has been implicated as being necessary for the optimal formation of primary CD8+ T cell responses against various pathogens. Here we have examined the role that IL-2 signaling plays in several aspects of a CD8+ T cell response against murine gammaherpesvirus 68 (MHV-68). Exposure to MHV-68 causes a persistent infection, along with infectious mononucleosis, providing a model for studying these processes in mice. Our study indicates that CD25 is necessary for optimal expansion of the antigen-specific CD8+ T cell response but not for the long-term memory response. Contrastingly, IL-2 signaling through CD25 is absolutely required for CD8+ T cell mononucleosis.


2001 ◽  
Vol 69 (2) ◽  
pp. 1226-1229 ◽  
Author(s):  
Hitoshi Nishimura ◽  
Mitsuhiko Tagaya ◽  
Hironaka Tsunobuchi ◽  
Haruhiko Suzuki ◽  
Izumi Nakashima ◽  
...  

ABSTRACT Interleukin-2 (IL-2)/IL-15 receptor β (IL-15Rβ)−/− mice were susceptible to infection with avirulent Salmonella enterica subsp. entericaserovar Choleraesuis, whereas IL-2−/− mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2−/− but not in IL-2/IL-15Rβ−/− mice infected with Salmonella, suggesting that IL-2/IL-15Rβ signaling is important for the generation of protective Th1 cells.


2017 ◽  
Vol 15 (5) ◽  
pp. 776-788 ◽  
Author(s):  
Asma Kazemi ◽  
Kurosh Djafarian ◽  
John R. Speakman ◽  
Parviz Sabour ◽  
Sepideh Soltani ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document