Monoclonal and Polyclonal Hypergammaglobulinemia: Clinical and Biological Significance.Jan Gosta Waldenstrom

1969 ◽  
Vol 44 (3) ◽  
pp. 338-339
Keyword(s):  
Polyclonal Hypergammaglobulinemia

scholarly journals Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: Report of a case.

1991 ◽  
Vol 30 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Tadanori NAGAI ◽  
Rhyuzou KOYAMA ◽  
Yutaka SASAGAWA ◽  
Shuji MATSUMOTO ◽  
Yohoshiro NIISU ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Polyclonal Hypergammaglobulinemia

scholarly journals Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome

Hematology ◽  
2000 ◽  
Vol 5 (2) ◽  
pp. 163-165 ◽  
Author(s):  
Tohru Murayama ◽  
Yoshitake Hayashi ◽  
Shion Imoto ◽  
Manabu Shimoyama ◽  
Hiroshi Matsuoka ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Necrosis ◽  
Polyclonal Hypergammaglobulinemia ◽  
Blue Toe Syndrome ◽  
Massive Bone

Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children

1999 ◽  
Vol 78 (10) ◽  
pp. 445-448
Author(s):  
G. Surico ◽  
P. Muggeo ◽  
V. Muggeo ◽  
A. Lucarelli ◽  
C. Novielli ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Polyclonal Hypergammaglobulinemia ◽  
Leukemia In Children ◽  
Acute Myeloid

scholarly journals Granulated T cell lymphocytosis with neutropenia: malignant or benign chronic lymphoproliferative disorder?

Blood ◽  
1985 ◽  
Vol 66 (2) ◽  
pp. 259-266
Author(s):  
RW McKenna ◽  
DC Arthur ◽  
KJ Gajl-Peczalska ◽  
P Flynn ◽  
RD Brunning
Keyword(s):  
T Cell ◽  
Spontaneous Regression ◽  
Clinical Presentation ◽  
Chromosome Abnormalities ◽  
Severe Neutropenia ◽  
Persistent Lymphocytosis ◽  
Blood Lymphocytes ◽  
Polyclonal Hypergammaglobulinemia ◽  
Suppressor T Lymphocyte ◽  
Pulse Steroid

The clinical, morphological, immunologic, and cytogenetic features of seven cases of chronic granulated T cell lymphocytosis with neutropenia were studied. The disorder was characterized by moderate blood and bone marrow lymphocytosis, neutropenia, polyclonal hypergammaglobulinemia, splenomegaly, absence of lymphadenopathy, and a chronic, relatively stable clinical course. The proliferative lymphocytes manifested a cytotoxic/suppressor T lymphocyte phenotype. In two of four cases studied, blood lymphocytes showed clonal chromosome abnormalities. One patient treated with pulse steroid therapy had reversal of lymphocytosis and severe neutropenia with subsequent resolution of an intractable infection. The lymphocytosis and neutropenia recurred when steroids were withdrawn. Six of the seven patients were living three months to 17 years from diagnosis; one died at 4.3 years of an unrelated cause. Five of the patients, including the two with lymphocyte chromosome abnormalities, had persistent lymphocytosis and neutropenia from three months to 13 years from diagnosis. In two patients, the disease appears to have undergone spontaneous regression. No differences in clinical presentation or the morphological or immunologic characteristics of the proliferative lymphocytes were apparent between those patients with lymphocyte chromosome abnormalities and persistent disease and those who had a spontaneous regression. The finding of clonal chromosome abnormalities in the blood lymphocytes of two of the patients in this study suggests a neoplastic origin for chronic granulated T cell lymphocytosis with neutropenia. However, apparent spontaneous regression in two patients, one after 11 years, lends support to a chronic reactive or immunoregulatory disorder as the etiology. It is probable that cases of granulated T cell lymphocytosis with neutropenia, although morphologically and immunologically similar, are biologically heterogeneous.

Acquired Hypolipoproteinemia

1992 ◽  
Vol 38 (5) ◽  
pp. 776-781 ◽  
Author(s):  
M De Buyzere ◽  
J Delanghe ◽  
C Labeur ◽  
L Noens ◽  
Y Benoit ◽  
...  
Keyword(s):  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Acyltransferase Activity ◽  
Apo B ◽  
Familial Predisposition ◽  
Low Concentrations ◽  
Polyclonal Hypergammaglobulinemia ◽  
Severe Infections ◽  
Hematological Abnormalities

Abstract We present a six-year follow-up of a boy with a novel type of hypolipoproteinemia, with clinical and biochemical features distinct from classical hypoalphalipoproteinemias. There were abnormally low concentrations of total and high-density lipoprotein (HDL) cholesterol, apolipoprotein (apo) B, apo A-I, and apo A-II, and the phospholipids were decreased. The most striking abnormality was an extra fraction containing mainly phospholipids and apo A-I in the HDL3 subfraction. This fraction is reminiscent of concentric 20- to 50-nm-diameter lamellar phospholipid liposomes. Plasma lecithin:cholesterol acyltransferase activity was strongly decreased. We noted a persisting polyclonal hypergammaglobulinemia, hematological abnormalities (hemolytic anemia and thrombocytopenia), and a progressive splenomegaly. After the five-year follow-up, the patient had recurrent severe infections; moderate hematuria and proteinuria developed gradually. Treatment with corticosteroids and immunoglobulins improved thrombocytopenia and hypolipoproteinemia. These clinical and biochemical findings differ from those in the known primary and secondary hypo-alpha-lipoproteinemia syndromes. Although investigation of the relatives suggests a familial predisposition for hypo-alpha-lipoproteinemia, the subject's condition can be regarded as acquired.

scholarly journals Immunologic characterization of a helper T-cell lymphoma

Blood ◽  
1982 ◽  
Vol 59 (4) ◽  
pp. 702-708 ◽  
Author(s):  
M Gramatzki ◽  
MF Dolan ◽  
AS Fauci ◽  
JA Maples ◽  
GD Bonnard ◽  
...  
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Interleukin 2 ◽  
Cell Subset ◽  
Peripheral Blood Lymphocytes ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Helper T Cell ◽  
Cell Surface Antigens ◽  
Polyclonal Hypergammaglobulinemia ◽  
Almost All

Abstract The lymphocytes of a patient with a T-cell non-Hodgkin's lymphoma with peripheral blood involvement and polyclonal hypergammaglobulinemia were characterized in terms of surface markers and immunologic functions. Using the fluorescence-activated cell sorter and employing various monoclonal antibodies against T-cell surface antigens, it was shown that almost all of the patient's peripheral blood lymphocytes were positive for OKT4 and 9.3, antibodies that recognize helper T-cell subset. The circulating lymphoma cells had typical characteristics for T cells; they formed spontaneous rosettes with sheep erythrocytes and stained with the pan-T-cell antibodies 9.6 and 10.2, but did not react with other anti-T-cell monoclonal reagents such as OKT3, UCHT-1, and 3A1. The cells appeared to be mature by the fact that they did not stain with OKT6, and terminal deoxynucleotidyl transferase was undetectable. Functionally, they were able to provide “help” for antibody production, and they could be stimulated to produce moderate amounts of interleukin-2, while unable to proliferate in response to mitogens. Morphologically, some of the lymphocytes showed a deeply cleaved nucleus.

A case of angioimmunoblastic T-cell lymphoma with bone marrow involvement, polyclonal hypergammaglobulinemia and skin rash

Skin Cancer ◽  
2011 ◽  
Vol 26 (2) ◽  
pp. 134-138
Author(s):  
Norihiro SUZUKI ◽  
Daisuke SUZUKI ◽  
Atsushi FUJITA ◽  
Chiyo NOMURA ◽  
Kazuyasu FUJII ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Skin Rash ◽  
Cell Lymphoma ◽  
Bone Marrow Involvement ◽  
T Cell Lymphoma ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Polyclonal Hypergammaglobulinemia

Clinical Implication of Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Report of 16 Cases

2004 ◽  
Vol 12 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Masaru Kojima ◽  
Shigeo Nakamura ◽  
Kazuhiko Shimizu ◽  
Hideaki Itoh ◽  
Yuko Yamane ◽  
...  
Keyword(s):  
Clinical Implication ◽  
Polyclonal Hypergammaglobulinemia

Hairy Cells from Hairy Cell Leukemia Patients Presenting with Pronounced Polyclonal Hypergammaglobulinemia Secrete a Factor Enhancing IgG Synthesis

1993 ◽  
Vol 66 (3) ◽  
pp. 212-218 ◽  
Author(s):  
Yoshihisa Nakamura ◽  
Takashi Machii ◽  
Yukihiro Tokumine ◽  
Ryoichi Inoue ◽  
Masaru Shibano ◽  
...  
Keyword(s):  
Hairy Cell Leukemia ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Igg Synthesis ◽  
Polyclonal Hypergammaglobulinemia ◽  
Hairy Cells
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