Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids. Richard Durbin , Sean R. Eddy , Anders Krogh , Graeme Mitchison

2000 ◽  
Vol 75 (3) ◽  
pp. 313-314 ◽  
Author(s):  
Gary D. Stormo
Keyword(s):  
Sequence Analysis ◽  
Nucleic Acids ◽  
Probabilistic Models ◽  
Biological Sequence ◽  
Biological Sequence Analysis

Representation learning applications in biological sequence analysis

2021 ◽  
Author(s):  
Hitoshi Iuchi ◽  
Taro Matsutani ◽  
Keisuke Yamada ◽  
Shunsuke Sumi ◽  
Shion Hosoda ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Language Processing ◽  
High Throughput Sequencing ◽  
Probabilistic Models ◽  
Representation Learning ◽  
Biological Sequences ◽  
Biological Sequence ◽  
Structure Estimation ◽  
Biological Sequence Analysis ◽  
Essential Step

Remarkable advances in high-throughput sequencing have resulted in rapid data accumulation, and analyzing biological (DNA/RNA/protein) sequences to discover new insights in biology has become more critical and challenging. To tackle this issue, the application of natural language processing (NLP) to biological sequence analysis has received increased attention, because biological sequences are regarded as sentences and k-mers in these sequences as words. Embedding is an essential step in NLP, which converts words into vectors. This transformation is called representation learning and can be applied to biological sequences. Vectorized biological sequences can be used for function and structure estimation, or as inputs for other probabilistic models. Given the importance and growing trend in the application of representation learning in biology, here, we review the existing knowledge in representation learning for biological sequence analysis.

Sign in / Sign up

Export Citation Format

Share Document