scholarly journals Two Years’ Prospective Collection of Molecular and Epidemiological Data Shows Limited Spread of Hepatitis A Virus outside Risk Groups in Amsterdam, 2000–2002

2004 ◽  
Vol 189 (3) ◽  
pp. 471-482 ◽  
Author(s):  
Jim E. van Steenbergen ◽  
Grace Tjon ◽  
Anneke van den Hoek ◽  
Alex Koek ◽  
Roel A. Coutinho ◽  
...  
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Epidemiological Data ◽  
Risk Groups

scholarly journals Spillover of a hepatitis A outbreak among men who have sex with men (MSM) to the general population, the Netherlands, 2017

2018 ◽  
Vol 23 (23) ◽  
Author(s):  
Ingrid HM Friesema ◽  
Gerard JB Sonder ◽  
Mariska WF Petrignani ◽  
Annemarie E Meiberg ◽  
Gini GC van Rijckevorsel ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
General Population ◽  
The Netherlands ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Epidemiological Data ◽  
Risk Groups ◽  
Virus Genotypes ◽  
Sex With Men ◽  
The Impact

Since 2015, outbreaks of hepatitis A among men who have sex with men (MSM) have been reported worldwide. To examine the impact of these MSM outbreaks in the Netherlands, we combined notification and epidemiological data with sequence analysis. Our results show the hazards of outbreaks within risk-groups spilling over into the largely susceptible general population. One third of the outbreak-related hepatitis A virus genotypes were detected in non-MSM cases.

scholarly journals Susceptibility to Hepatitis A Virus Infection in the United States, 2007–2016

2020 ◽  
Vol 71 (10) ◽  
pp. e571-e579 ◽  
Author(s):  
Shaoman Yin ◽  
Laurie Barker ◽  
Kathleen N Ly ◽  
Greta Kilmer ◽  
Monique A Foster ◽  
...  
Keyword(s):  
United States ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Risk Groups ◽  
The United States ◽  
Poverty Level ◽  
Health And Nutrition ◽  
National Immunization ◽  
Vaccination Recommendations ◽  
Sex With Men

Abstract Background Despite national immunization efforts, including universal childhood hepatitis A (HepA) vaccination recommendations in 2006, hepatitis A virus (HAV)–associated outbreaks have increased in the United States. Unvaccinated or previously uninfected persons are susceptible to HAV infection, yet the susceptibility in the US population is not well known. Methods Using National Health and Nutrition Examination Survey 2007–2016 data, we estimated HAV susceptibility prevalence (total HAV antibody negative) among persons aged ≥2 years. Among US-born adults aged ≥20 years, we examined prevalence, predictors, and age-adjusted trends of HAV susceptibility by sociodemographic characteristics. We assessed HAV susceptibility and self-reported nonvaccination to HepA among risk groups and the “immunization cohort” (those born in or after 2004). Results Among US-born adults aged ≥20 years, HAV susceptibility prevalence was 74.1% (95% confidence interval, 72.9–75.3%) during 2007–2016. Predictors of HAV susceptibility were age group 30–49 years, non-Hispanic white/black, 130% above the poverty level, and no health insurance. Prevalences of HAV susceptibility and nonvaccination to HepA, respectively, were 72.9% and 73.1% among persons who reported injection drug use, 67.5% and 65.2% among men who had sex with men, 55.2% and 75.1% among persons with hepatitis B or hepatitis C, and 22.6% and 25.9% among the immunization cohort. Susceptibility and nonvaccination decreased over time among the immunization cohort but remained stable among risk groups. Conclusions During 2007–2016, approximately three-fourths of US-born adults remained HAV susceptible. Enhanced vaccination efforts are critically needed, particularly targeting adults at highest risk for HAV infection, to mitigate the current outbreaks.

Changing risk profile of hepatitis A in The Netherlands: a comparison of seroprevalence in 1995–1996 and 2006–2007

2011 ◽  
Vol 139 (8) ◽  
pp. 1172-1180 ◽  
Author(s):  
L. VERHOEF ◽  
H. J. BOOT ◽  
M. KOOPMANS ◽  
L. MOLLEMA ◽  
F. VAN DER KLIS ◽  
...  
Keyword(s):  
The Netherlands ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Risk Groups ◽  
Second World War ◽  
World War ◽  
Susceptible Population ◽  
Prophylactic Vaccination ◽  
The Cost ◽  
Second World

SUMMARYThe prevalence of antibodies to hepatitis A virus (HAV) was assessed in a nationwide sample (n=6229) in The Netherlands in 2006–2007, and compared to the seroprevalence in a similar study in 1995–1996 (n=7376). The overall seroprevalence increased from 34% in 1995–1996 to 39% in 2006–2007, mainly due to vaccination of travellers and an increased immigrant population. Risk factors remain travelling to, and originating from, endemic regions, and vaccination is targeted currently at these risk groups. Our results show a trend of increasing age of the susceptible population. These people would also benefit from HAV vaccination because they are likely to develop clinically serious symptoms after infection, and are increasingly at risk of exposure through imported viruses through foods or travellers. The cost-effectiveness of adding elderly people born after the Second World War as a target group for prophylactic vaccination to reduce morbidity and mortality after HAV infection should be assessed.

scholarly journals Comparative hepatitis A seroepidemiology in 10 European countries

2012 ◽  
Vol 140 (12) ◽  
pp. 2172-2181 ◽  
Author(s):  
S. KURKELA ◽  
R. PEBODY ◽  
G. KAFATOS ◽  
N. ANDREWS ◽  
C. BARBARA ◽  
...  
Keyword(s):  
Disease Burden ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Age Groups ◽  
Risk Groups ◽  
Vaccination Policy ◽  
Laboratory Results ◽  
Children And Young Adults ◽  
Middle Aged Adults ◽  
Local Laboratory

SUMMARYThe WHO recommends hepatitis A virus (HAV) immunization according to level of transmission and disease burden. We aimed to identify susceptible age groups by standardized serosurveys to inform HAV vaccination policy in participating countries: Belgium, Czech Republic, England, Finland, Germany, Italy, Lithuania, Malta, Romania, and Slovakia. Each country tested national serum banks (n = 1854–6748), collected during 1996–2004, for anti-HAV antibodies. Local laboratory results were standardized to common units. Forty-one per cent of those aged <30 years and 6% of those aged ⩾30 years were susceptible to HAV in Romania; compared to 70–94% and 26–71%, respectively, elsewhere. Romania reported high HAV incidence in children and young adults. Other countries reported HAV disease primarily in older risk groups. The results suggest low level of HAV transmission in most of Europe. Romania, however, appeared as an area with intermediate transmission. Vaccination of risk groups in countries with high susceptibility of young and middle-aged adults needs to be continued.

scholarly journals Estimating the critical immunity threshold for preventing hepatitis A outbreaks in men who have sex with men

2015 ◽  
Vol 144 (7) ◽  
pp. 1528-1537 ◽  
Author(s):  
D. G. REGAN ◽  
J. G. WOOD ◽  
C. BENEVENT ◽  
H. ALI ◽  
L. WATCHIRS SMITH ◽  
...  
Keyword(s):  
High Risk ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Reproduction Number ◽  
Vaccine Coverage ◽  
Risk Groups ◽  
Developed Countries ◽  
Population Immunity ◽  
Sex With Men ◽  
The Basic Reproduction Number

SUMMARYSeveral outbreaks of hepatitis A in men who have sex with men (MSM) were reported in the 1980s and 1990s in Australia and other countries. An effective hepatitis A virus (HAV) vaccine has been available in Australia since 1994 and is recommended for high-risk groups including MSM. No outbreaks of hepatitis A in Australian MSM have been reported since 1996. In this study, we aimed to estimate HAV transmissibility in MSM populations in order to inform targets for vaccine coverage in such populations. We used mathematical models of HAV transmission in a MSM population to estimate the basic reproduction number (R0) and the probability of an HAV epidemic occurring as a function of the immune proportion. We estimated a plausible range forR0of 1·71–3·67 for HAV in MSM and that sustained epidemics cannot occur once the proportion immune to HAV is greater than ~70%. To our knowledge this is the first estimate ofR0and the critical population immunity threshold for HAV transmission in MSM. As HAV is no longer endemic in Australia or in most other developed countries, vaccination is the only means of maintaining population immunity >70%. Our findings provide impetus to promote HAV vaccination in high-risk groups such as MSM.

scholarly journals Immunization strategies to control a community-wide hepatitis A epidemic

2001 ◽  
Vol 127 (3) ◽  
pp. 461-467 ◽  
Author(s):  
K. M. THORBURN ◽  
R. BOHORQUES ◽  
P. STEPAK ◽  
L. L. SMITH ◽  
C. JOBB ◽  
...  
Keyword(s):  
High Risk ◽  
Injection Drug Users ◽  
Drug Users ◽  
Hepatitis A ◽  
Illicit Drug ◽  
Hepatitis A Virus ◽  
Risk Groups ◽  
Jail Inmates ◽  
Illicit Drug Users ◽  
Immunization Strategies

One fifth of 527 cases of hepatitis A occurred in self-identified injection drug users during a community-wide epidemic in Spokane County (Washington) in 1997–8. We hypothesized that an immunization campaign targeted at illicit drug users could control the epidemic. Starting in May 1998, hepatitis A vaccine was provided to individuals in jails and other sites frequented by illicit drug users. Volunteers at vaccination sites were surveyed about risk. Serial convenience samples of jail inmates who denied previous vaccination were anonymously tested for hepatitis A virus (HAV) immunoglobulin G (IgG). From May to December 1998, 2765 high-risk individuals were vaccinated against hepatitis A. The proportion of HAV IgG seropositive inmates increased from 30% to more than 50%. Our findings suggest that vaccination along with naturally occurring infection increased the rate of hepatitis A immunity among illicit drug users during the final months of the epidemic. This supports the hypothesis that targeted immunization of high risk groups may shorten the natural history of a community-wide epidemic.

scholarly journals Usability of the international HAVNet hepatitis A virus database for geographical annotation, backtracing and outbreak detection

2018 ◽  
Vol 23 (37) ◽  
Author(s):  
Annelies Kroneman ◽  
Rita de Sousa ◽  
Linda Verhoef ◽  
Marion P G Koopmans ◽  
Harry Vennema ◽  
...  
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Descriptive Analysis ◽  
Epidemiological Data ◽  
Genomic Region ◽  
Outbreak Detection ◽  
Geographical Differences ◽  
Geographic Coverage ◽  
International Laboratory ◽  
Common Sequence

Background HAVNet is an international laboratory network sharing sequences and corresponding metadata on hepatitis A virus in an online database. Aim: We give an overview of the epidemiological and genetic data and assess the usability of the present dataset for geographical annotation, backtracing and outbreak detection. Methods: A descriptive analysis was performed on the timeliness, completeness, epidemiological data and geographic coverage of the dataset. Length and genomic region of the sequences were reviewed as well as the numerical and geographical distribution of the genotypes. The geographical signal in the sequences was assessed based on a short common nt stretch using a 100% identity analysis. Results: The 9,211 reports were heterogeneous for completeness and timeliness, and for length and genomic region of the sequences. Some parts of the world were not represented by the sequences. Geographical differences in prevalence of HAV genotypes described previously could be confirmed with this dataset and for a third (1,075/3,124) of the included sequences, 100% identity of the short common sequence coincided with an identical country of origin. Conclusion: Analysis of a subset of short, shared sequences indicates that a geographical annotation on the level of individual countries is possible with the HAVNet data. If the current incompleteness and heterogeneity of the data can be improved on, HAVNet could become very useful as a worldwide reference set for geographical annotation and for backtracing and outbreak detection.

scholarly journals Hepatitis A in Poland in 2017 - epidemic increase cases

2019 ◽  
pp. 487-497
Keyword(s):  
Infectious Diseases ◽  
Rural Areas ◽  
Hepatitis A ◽  
Fold Increase ◽  
Epidemiological Data ◽  
Risk Groups ◽  
Individual Case ◽  
Female Ratio ◽  
Aggregated Data ◽  
The Individual

AIM. The aim of this article is to describe and assess changes in epidemiological situation of Hepatitis A in Poland in 2017. MATERIALS AND METHODS. The assessment was based on the information from the individual case questionnaires, aggregated data from the bulletins “Infectious diseases and poisonings in Poland in 2017” and reports from epidemiological investigations in outbreaks of hepatitis A, submitted by the sanitary-epidemiological stations to the Department of Epidemiology of Infectious Diseases and Surveillance in NIPH-NIH. RESULTS. In 2017 a large increase of HAV cases and hepatitis A incidence was observed in Poland (3006 cases, incidence 7.8 per 100 000) in comparison to 2016 (35; 0.09). Majority of the cases were registered in large cities, where incidence was 3 times higher than in rural areas. Among reported there were 501 cases (16.6% of all cases) selfdeclaring as man who have sex with man (MSM). In course of the year an increasing trend in the number of cases was observed until September and the increase of male to female ratio (m/f) until May. Moreover 251 HAV outbreaks were reported, number of which increased until October and with the increase of m/f ratio in these outbreaks until April. From July to October there was an increase in the number of small outbreaks with m/f ratio equal 1. There were 178 imported cases reported, most of them from European countries- especially Germany and Spain. SUMMARY AND CONCLUSIONS. In 2017 over 80-fold increase of HAV cases and hepatitis A incidence was observed in comparison to previous years. Available epidemiological data indicate that ongoing HAV outbreak among MSM in Europe reached also Poland, and data from the second part of the year suggest infection spreading in non-MSM part of the population. It is therefore highly indicated that the list of risk groups for which vaccination against hepatitis A is recommended should also be expanded for MSM. To avoid such increase in the number of cases in future it is recommended to introduce vaccinations in risk groups as soon as large international outbreak occurs.

Factors associated with hepatitis A virus infection among HIV-positive patients before and after implementation of a hepatitis A virus vaccination program at a medical centre in central Taiwan

Sexual Health ◽  
2020 ◽  
Vol 17 (3) ◽  
pp. 239
Author(s):  
Jia-Juen Lin ◽  
Yuan-Ti Lee ◽  
Hao-Jan Yang
Keyword(s):  
Hepatitis A ◽  
Cox Regression ◽  
Hepatitis A Virus ◽  
Preventive Measure ◽  
Risk Groups ◽  
Vaccination Rate ◽  
Hiv Positive ◽  
Adjusted Relative Risk ◽  
Vaccination Policy ◽  
Central Taiwan

Background Taiwan government has promoted the administration of a hepatitis A vaccine at public expense for high-risk groups as a preventive measure after the outbreak of hepatitis A virus (HAV) infections in 2015. The aim of this study was to evaluate the efficacy of such vaccination policy in patients with human immunodeficiency virus (HIV). Methods: From January 2016 to July 2017, we enrolled 658 HIV-positive male participants. Participants were stratified into anti-HAV-positive (n = 165) and anti-HAV-negative (n = 493) groups. A total of 364 anti-HAV-negative patients received vaccination against HAV and were followed up for 1.5 years. A Cox regression model was used to estimate the effects of factors predicting positive anti-HAV detection after vaccination. Results: Patients with HIV had an anti-HAV-positive prevalence of 25.1% before vaccination. Of the 364 patients inoculated with the first dose of vaccine, 58.0% received the second dose. Seroresponse rates were 50.0% and 80.6%, respectively. Antibody production was 30.0% lower in patients with a CD4 T-cell count &lt;200 cells/µL (adjusted relative risk (ARR) = 0.7; 95% confidence interval (CI) = 0.5–0.9) compared with those with 500 cells/µL. Hepatitis C co-infection reduced the production of antibodies by 50.0% (ARR = 0.5; 95% CI = 0.2–0.8). Conclusion: This study suggests that vaccination against hepatitis A be administered when the immunity of an HIV-positive patient is strong. The promotion of the current vaccination policy against hepatitis A in Taiwan has improved the vaccination rate; the response rate for receiving one dose of the vaccine doubled.

scholarly journals A descriptive analysis of the spatiotemporal distribution of hepatitis A virus outbreak in Pacitan, East Java, Indonesia

2021 ◽  
Vol 129 (s2) ◽  
Author(s):  
Aditya Doni Pradana ◽  
Raissa Virgy Rianda ◽  
Zhanna Ovitha Riskhathusa ◽  
Swastika A. S. Asri ◽  
Rama Azalix Rianda ◽  
...  
Keyword(s):  
Public Health ◽  
Viral Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Descriptive Analysis ◽  
Temporal Distribution ◽  
Epidemiological Data ◽  
Spatiotemporal Distribution ◽  
Socioeconomic Determinants ◽  
Spatio Temporal

Background: Hepatitis A virus (HAV) is one of the most serious notifiable viral hepatitis and causing public health problems in Indonesia. The outbreaks of HAV in Indonesia have been reported in several sites from 1998-2018, however systematic epidemiological data regarding Spatio-temporal distribution of HAV outbreaks are lacking. Aims: To explore, visualize, and report systematically the recent HAV outbreak and identify the socioeconomic determinants associated with the risk of HAV outbreak.

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