scholarly journals Injectable Contraceptive Use and Genital Ulcer Disease during the Early Phase of HIV‐1 Infection Increase Plasma Virus Load in Women

2004 ◽  
Vol 189 (2) ◽  
pp. 303-311 ◽  
Author(s):  
Ludo Lavreys ◽  
Jared M. Baeten ◽  
Joan K. Kreiss ◽  
Barbra A. Richardson ◽  
Bhavna H. Chohan ◽  
...  
Keyword(s):  
Early Phase ◽  
Contraceptive Use ◽  
Genital Ulcer ◽  
Plasma Virus ◽  
Virus Load ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Injectable Contraceptive ◽  
Plasma Virus Load ◽  
Hiv 1

Increasing HIV-1 seroprevalence associated with genital ulcer disease, New York City, 1990-1992

AIDS ◽  
1995 ◽  
Vol 9 (2) ◽  
pp. 177-182
Author(s):  
Lucia V. Torian ◽  
Isaac B. Weisfuse ◽  
Hadi A. Makki ◽  
Deborah A. Benson ◽  
Linda M. DiCamillo ◽  
...  
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Hiv 1

Impact of aciclovir on ulcer healing, lesional, genital and plasma HIV-1 RNA among patients with genital ulcer disease in Malawi

2010 ◽  
Vol 86 (5) ◽  
pp. 345-352 ◽  
Author(s):  
S. Phiri ◽  
I. F. Hoffman ◽  
H. A. Weiss ◽  
F. Martinson ◽  
N. Nyirenda ◽  
...  
Keyword(s):  
Ulcer Healing ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Hiv 1

Increasing HIV-1 seroprevalence associated with genital ulcer disease, New York City, 1990-1992

AIDS ◽  
1995 ◽  
Vol 9 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Lucia V. Torian ◽  
Isaac B. Weisfuse ◽  
Hadi A. Makki ◽  
Deborah A. Benson ◽  
Linda M. DiCamillo ◽  
...  
Keyword(s):  
New York ◽  
New York City ◽  
York City ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Hiv 1

scholarly journals Relationship between In Vitro Human Immunodeficiency Virus Type 1 Replication Rate and Virus Load in Plasma

2003 ◽  
Vol 77 (22) ◽  
pp. 12105-12112 ◽  
Author(s):  
Thomas B. Campbell ◽  
Kristina Schneider ◽  
Terri Wrin ◽  
Christos J. Petropoulos ◽  
Elizabeth Connick
Keyword(s):  
Replication Capacity ◽  
Replication Rate ◽  
Plasma Virus ◽  
Virus Load ◽  
Immunodeficiency Virus ◽  
Plasma Virus Load ◽  
Hiv 1 ◽  
Rna Concentration

ABSTRACT Although plasma human immunodeficiency virus type 1 (HIV-1) RNA concentration is a major determinant of the rate of HIV-1 disease progression, the reasons for variability in plasma virus loads among infected individuals are not fully understood. We conducted investigations with 15 HIV-1-infected individuals who were not receiving antiretroviral therapy to evaluate the hypothesis that HIV-1 replication rate in vitro is a significant determinant of plasma virus load. Virus could not be isolated from one subject. Two subjects were excluded because they had features previously associated with distinct plasma virus loads and altered rates of disease progression; one harbored a syncytium-inducing virus and the second was heterozygous for a 32-bp deletion from the CCR5 gene. HIV-1 replication rates were determined by culturing autologous virus isolates in phytohemagglutinin-treated peripheral blood mononuclear cells (PBMC) and determining the rate of p24 antigen production during the logarithmic phase of viral replication. The contribution of HIV-1 reverse transcriptase (RT) and protease (PR) alleles to replication capacity was assessed using recombinant viruses in a single-cycle infection assay. HIV-1 replication rates ranged from 0.15 to 0.76 log10 pg/ml/day and were reproducible within the same donor PBMC (coefficient of variation ± 4%). RT-PR replication capacity ranged from 14 to 95% of that of control virus and was linearly related to replication rate (r 2 = 0.53; P = 0.007). Plasma HIV-1 RNA concentration was linearly related to replication rate (r 2 = 0.71; P < 0.001) and RT-PR replication capacity (r 2 = 0.44; P = 0.019). These data suggest that different RT-PR alleles are important determinants of HIV-1 replication rates and that HIV-1 replication rate explains much of the variability in plasma virus load in chronic HIV-1 infection.

scholarly journals Effect of Genital Ulcer Disease on HIV‐1 Coreceptor Expression in the Female Genital Tract

2007 ◽  
Vol 196 (10) ◽  
pp. 1509-1516 ◽  
Author(s):  
Jeanne S. Sheffield ◽  
George D. Wendel, Jr. ◽  
Donald D. McIntire ◽  
Michael V. Norgard
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Hiv 1 ◽  
Female Genital

Cervicovaginal HIV-1 and herpes simplex virus type 2 shedding during genital ulcer disease episodes

AIDS ◽  
2007 ◽  
Vol 21 (12) ◽  
pp. 1569-1578 ◽  
Author(s):  
J??r??me LeGoff ◽  
Helen A Weiss ◽  
G??rard Gresenguet ◽  
Khonde Nzambi ◽  
Eric Frost ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Simplex Virus ◽  
Hiv 1

Association Between HIV-1 Infection, the Etiology of Genital Ulcer Disease, and Response to Syndromic Management

2003 ◽  
Vol 30 (3) ◽  
pp. 241-245 ◽  
Author(s):  
PRASHINI MOODLEY ◽  
PATRICK D. J. STURM ◽  
TRUSHA VANMALI ◽  
DAVID WILKINSON ◽  
CATHY CONNOLLY ◽  
...  
Keyword(s):  
Genital Ulcer ◽  
Syndromic Management ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Hiv 1

scholarly journals Acute HIV Infections among Men with Genital Ulcer Disease in South Africa

2010 ◽  
Vol 201 (12) ◽  
pp. 1811-1815 ◽  
Author(s):  
G. Paz Bailey ◽  
M. Sternberg ◽  
D. A. Lewis ◽  
A. Puren
Keyword(s):  
South Africa ◽  
Hiv Infections ◽  
Genital Ulcer ◽  
Ulcer Disease ◽  
Genital Ulcer Disease ◽  
Acute Hiv
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