scholarly journals Protective Efficacy of Hepatitis E Virus DNA Vaccine Administered by Gene Gun in the Cynomolgus Macaque Model of Infection

2004 ◽  
Vol 189 (2) ◽  
pp. 258-264 ◽  
Author(s):  
Saleem Kamili ◽  
John Spelbring ◽  
Dorrie Carson ◽  
Krzysztof Krawczynski
Keyword(s):  
Dna Vaccine ◽  
Hepatitis E Virus ◽  
Protective Efficacy ◽  
Cynomolgus Macaque ◽  
Hepatitis E ◽  
Gene Gun ◽  
Macaque Model

scholarly journals In VitroInfection and Replication of Hepatitis E Virus in Primary Cynomolgus Macaque Hepatocytes

Virology ◽  
1997 ◽  
Vol 238 (1) ◽  
pp. 94-102 ◽  
Author(s):  
Albert W Tam ◽  
Robert White ◽  
Patrice O Yarbough ◽  
Brendan J Murphy ◽  
C.Patrick McAtee ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Cynomolgus Macaque ◽  
Hepatitis E

Immunogenicity and protective efficacy of a vaccine prepared from 53 kDa truncated hepatitis E virus capsid protein expressed in insect cells

Vaccine ◽  
2001 ◽  
Vol 20 (5-6) ◽  
pp. 853-857 ◽  
Author(s):  
Mingdong Zhang ◽  
Suzanne U Emerson ◽  
Hanh Nguyen ◽  
Ronald E Engle ◽  
Sugantha Govindarajan ◽  
...  
Keyword(s):  
Capsid Protein ◽  
Hepatitis E Virus ◽  
Insect Cells ◽  
Protective Efficacy ◽  
Hepatitis E ◽  
Virus Capsid ◽  
Virus Capsid Protein

Immunogenicity of candidate hepatitis E virus DNA vaccine expressing complete and truncated ORF2 in mice

Vaccine ◽  
2007 ◽  
Vol 25 (22) ◽  
pp. 4350-4360 ◽  
Author(s):  
Tejaswini M. Deshmukh ◽  
Kavita S. Lole ◽  
Anuradha S. Tripathy ◽  
Vidya A. Arankalle
Keyword(s):  
Dna Vaccine ◽  
Hepatitis E Virus ◽  
Hepatitis E

scholarly journals Tuberculosis DNA Vaccine Encoding Ag85A Is Immunogenic and Protective When Administered by Intramuscular Needle Injection but Not by Epidermal Gene Gun Bombardment

2000 ◽  
Vol 68 (7) ◽  
pp. 3854-3860 ◽  
Author(s):  
Audrey Tanghe ◽  
Olivier Denis ◽  
Bénédicte Lambrecht ◽  
Vinciane Motte ◽  
Thierry van den Berg ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Cytotoxic T Lymphocyte ◽  
Protective Efficacy ◽  
Interleukin 2 ◽  
Gene Gun ◽  
Antibody Isotypes ◽  
C57bl Mice ◽  
Ifn Γ ◽  
Lymphocyte Responses ◽  
Needle Injection

ABSTRACT Immunogenicity and protective efficacy of a DNA vaccine encoding Ag85A from Mycobacterium tuberculosis were compared in BALB/c and C57BL (B6 and B10) mice immunized by intramuscular (i.m.) needle injection or epidermal gene gun (gg) bombardment. In BALB/c mice, gg immunization could induce elevated antibody and cytotoxic T lymphocyte responses with plasmid doses 50-fold lower than those required for i.m. immunization. Interleukin-2 (IL-2) and gamma interferon (IFN-γ) secretion, however, was much lower in gg-immunized than in i.m.-immunized BALB/c mice. On the other hand, C57BL mice reacted only very weakly to gg immunization, whereas elevated Ag85A-specific antibody, IL-2, and IFN-γ responses (significantly higher than in BALB/c mice) were detected following vaccination by the i.m. route. Antibody isotypes were indicative of Th2 activation following gg injection of BALB/c and of Th1 activation following i.m. injection of C57BL mice. Finally, C57BL but not BALB/c mice were protected by i.m. Ag85A DNA immunization against intravenousM. tuberculosis challenge, as measured by reduced numbers of CFU in spleen and lungs, compared to animals vaccinated with control DNA. Gene gun immunization was not effective in either BALB/c or C57BL mice. These results indicate that i.m. DNA vaccination is the method of choice for the induction of protective Th1 type immune responses with the Ag85A tuberculosis DNA vaccine.

Hepatitis E virus DNA vaccine elicits immunologic memory in mice

2001 ◽  
Vol 8 (2) ◽  
pp. 223-226 ◽  
Author(s):  
Junkun He ◽  
Curtis G. Hayes ◽  
Leonard N. Binn ◽  
Jitvimol Seriwatana ◽  
David W. Vaughn ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Immunologic Memory

Enhancement of Hepatitis E Virus DNA Vaccine Immunity by Beclin-1- Mediated Autophagy

2017 ◽  
Vol 10 (12) ◽  
Author(s):  
Hamed Naziri ◽  
Asghar Abdoli ◽  
Amir Ghaemi ◽  
Fatemeh Motevalli ◽  
Parviz Owlia ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Beclin 1 ◽  
Vaccine Immunity

Immunogenicity and protective efficacy in rhesus monkeys of a recombinant ORF2 protein from hepatitis E virus genotype 4

2009 ◽  
Vol 154 (3) ◽  
pp. 481-488 ◽  
Author(s):  
W. J. Huang ◽  
H. Y. Zhang ◽  
T. J. Harrison ◽  
H. Y. Lan ◽  
G. Y. Huang ◽  
...  
Keyword(s):  
Rhesus Monkeys ◽  
Hepatitis E Virus ◽  
Protective Efficacy ◽  
Hepatitis E ◽  
Virus Genotype ◽  
Genotype 4 ◽  
Recombinant Orf2 Protein ◽  
Orf2 Protein

Hepatitis E Virus in LeberBiopsien von Patienten mit akuter Hepatitis unbekannter Ätiologie

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
C Dorloff ◽  
J Hemberger ◽  
M Odenthal ◽  
H Holzmann ◽  
S Aberle ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E
Sign in / Sign up

Export Citation Format

Share Document