scholarly journals Serum Bactericidal Activity of the Methoxyfluoroquinolones Gatifloxacin and Moxifloxacin against Clinical Isolates of Staphylococcus Species: Are the Susceptibility Breakpoints Too High?

2003 ◽  
Vol 37 (10) ◽  
pp. 1392-1395 ◽  
Author(s):  
G. E. Stein ◽  
S. Schooley ◽  
G. W. Kaatz
Keyword(s):  
Bactericidal Activity ◽  
Clinical Isolates ◽  
Serum Bactericidal Activity

scholarly journals Synergistic Activities of Moxifloxacin Combined with Piperacillin-Tazobactam or Cefepime against Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii Clinical Isolates

2004 ◽  
Vol 48 (3) ◽  
pp. 1055-1057 ◽  
Author(s):  
Rose Jung ◽  
Maroof Husain ◽  
Michael K. Choi ◽  
Douglas N. Fish
Keyword(s):  
Klebsiella Pneumoniae ◽  
Acinetobacter Baumannii ◽  
Bactericidal Activity ◽  
Enterobacter Cloacae ◽  
Clinical Isolates ◽  
Time Kill

ABSTRACT The bactericidal activity of moxifloxacin alone and in combination with cefepime or piperacillin-tazobactam against clinical isolates of Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii was evaluated by using time-kill methods and antimicrobial concentrations of one-half and one times the MIC. Synergy was observed in 58 to 88% of the strains and resulted in bactericidal activity against 60 to 100% of the strains. Combinations including moxifloxacin demonstrated enhanced bactericidal activity compared with that of either agent tested alone.

scholarly journals BIOCINE® MENINGOCOCCAL C (MenC) CONJUGATE VACCINE ELICITS HIGH TITERS OF SERUM BACTERICIDAL ACTIVITY IN TODDLERS. ▴ 1053

1996 ◽  
Vol 39 ◽  
pp. 178-178 ◽  
Author(s):  
Noni N.E MacDonald ◽  
Scott Halperin ◽  
Barbara Law ◽  
Bruce D Forrest ◽  
Ahmad Mokatrin ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Bactericidal Activity ◽  
Serum Bactericidal Activity

scholarly journals Antiidiotypic DNA vaccination induces serum bactericidal activity and protection against group B meningococci

2006 ◽  
Vol 203 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Concetta Beninati ◽  
Angelina Midiri ◽  
Giuseppe Mancuso ◽  
Carmelo Biondo ◽  
Milena Arigò ◽  
...  
Keyword(s):  
Bactericidal Activity ◽  
Capsular Polysaccharide ◽  
Signal Sequence ◽  
Developed Countries ◽  
Single Chain ◽  
Serum Bactericidal Activity ◽  
Scfv Gene ◽  
Genes Encoding ◽  
Encapsulated Bacteria ◽  
Group B

No vaccine is available for preventing infections by serogroup B Neisseria meningitidis (MenB), which accounts for a major portion of meningococcal cases in developed countries, because of the poor immunogenicity of the capsular polysaccharide (CP) even after protein conjugation. We have previously induced anticapsular antibodies by immunization with a single chain variable fragment (scFv), which mimics a protective CP epitope. This surrogate antigen, however, was ineffective at inducing serum bactericidal activity, an accepted marker of protection in humans. Serum bactericidal activity was consistently achieved by immunizing mice with the scFv-encoding gene. Immunization with vectors without a secretory signal sequence before the scFv resulted in markedly higher bactericidal activity relative to those with such a sequence. The induced antibodies were capsule specific, as shown by complete inhibition of bactericidal activity by purified MenB CP and by resistance to killing of MenA or MenC. Moreover, these antibodies were predominantly of the IgG2a isotype, reflecting a T helper type 1 response. Administration of sera from scFv gene–vaccinated animals protected infant rats against MenB bacteremia. These data illustrate the potential of vaccination with genes encoding capsular mimics in providing protection against MenB and other encapsulated bacteria.

EFFECT OF RENAL PHYSICO-CHEMICAL MILIEU ON SERUM BACTERICIDAL ACTIVITY

1967 ◽  
Vol 253 (2) ◽  
pp. 225-229 ◽  
Author(s):  
EARL G. HUBERT ◽  
JOHN Z. MONTGOMERIE ◽  
GEOUGE M. KALMANSON ◽  
LUCIEN N. GUZE
Keyword(s):  
Bactericidal Activity ◽  
Serum Bactericidal Activity ◽  
Physico Chemical
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