Chronic Cold Exposure Increases Skeletal Muscle Oxidative Structure and Function inMonodelphis domestica, a Marsupial Lacking Brown Adipose Tissue

2003 ◽  
Vol 76 (6) ◽  
pp. 877-887 ◽  
Author(s):  
P. J. Schaeffer ◽  
J. J. Villarin ◽  
S. L. Lindstedt
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Structure And Function ◽  
Brown Adipose ◽  
And Function

Type 2 iodothyronine deiodinase is upregulated in rat slow- and fast-twitch skeletal muscle during cold exposure

2014 ◽  
Vol 307 (11) ◽  
pp. E1020-E1029 ◽  
Author(s):  
Ruy A. Louzada ◽  
Maria C. S. Santos ◽  
João Paulo A. Cavalcanti-de-Albuquerque ◽  
Igor F. Rangel ◽  
Andrea C. F. Ferreira ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Acclimation ◽  
Soleus Muscle ◽  
Cold Exposure ◽  
Skeletal Muscles ◽  
Nonshivering Thermogenesis ◽  
Brown Adipose

During cold acclimation, shivering is progressively replaced by nonshivering thermogenesis. Brown adipose tissue (BAT) and skeletal muscle are relevant for nonshivering thermogenesis, which depends largely on thyroid hormone. Since the skeletal muscle fibers progressively adapt to cold exposure through poorly defined mechanisms, our intent was to determine whether skeletal muscle type 2 deiodinase (D2) induction could be implicated in the long-term skeletal muscle cold acclimation. We demonstrate that in the red oxidative soleus muscle, D2 activity increased 2.3-fold after 3 days at 4°C together with the brown adipose tissue D2 activity, which increased 10-fold. Soleus muscle and BAT D2 activities returned to the control levels after 10 days of cold exposure, when an increase of 2.8-fold in D2 activity was detected in white glycolytic gastrocnemius but not in red oxidative gastrocnemius fibers. Propranolol did not prevent muscle D2 induction, but it impaired the decrease of D2 in BAT and soleus after 10 days at 4°C. Cold exposure is accompanied by increased oxygen consumption, UCP3, and PGC-1α genes expression in skeletal muscles, which were partialy prevented by propranolol in soleus and gastrocnemius. Serum total and free T3 is increased during cold exposure in rats, even after 10 days, when BAT D2 is already normalized, suggesting that skeletal muscle D2 activity contributes significantly to circulating T3 under this adaptive condition. In conclusion, cold exposure is accompanied by concerted changes in the metabolism of BAT and oxidative and glycolytic skeletal muscles that are paralleled by type 2 deiodinase activation.

scholarly journals Abnormal brown adipose tissue mitochondrial structure and function in IL10 deficiency

EBioMedicine ◽  
2019 ◽  
Vol 39 ◽  
pp. 436-447 ◽  
Author(s):  
José C. de-Lima-Júnior ◽  
Gabriela F. Souza ◽  
Alexandre Moura-Assis ◽  
Rodrigo S. Gaspar ◽  
Joana M. Gaspar ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Structure And Function ◽  
Mitochondrial Structure ◽  
Brown Adipose ◽  
And Function

scholarly journals Human Antigen R (HuR) Regulates Structure and Function of Brown Adipose Tissue

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Lindsey Lanzillotta ◽  
Sarah R. Anthony ◽  
Kaila Yamamoto ◽  
Shannon Jones ◽  
Zachary Taylor ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Structure And Function ◽  
Human Antigen R ◽  
Brown Adipose ◽  
And Function
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