scholarly journals De Novo Infection in a Renal Transplant Recipient Caused by Novel Mutants of Hepatitis B Virus Despite the Presence of Protective Anti–Hepatitis B Surface Antibody

2003 ◽  
Vol 187 (8) ◽  
pp. 1323-1326 ◽  
Author(s):  
Mengji Lu ◽  
Thomas Lorentz
Keyword(s):  
Hepatitis B Virus ◽  
Renal Transplant ◽  
Hepatitis B ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
De Novo ◽  
B Virus ◽  
Surface Antibody

Fibrosing cholestatic hepatitis in a renal transplant recipient associated with the hepatitis B virus precore mutant

1995 ◽  
Vol 22 (4) ◽  
pp. 500-503 ◽  
Author(s):  
Jonathan C.L. Booth ◽  
Rob D. Goldin ◽  
Jonathan L. Brown ◽  
Peter Karayiannis ◽  
Howard C. Thomas
Keyword(s):  
Hepatitis B Virus ◽  
Renal Transplant ◽  
Hepatitis B ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Cholestatic Hepatitis ◽  
B Virus ◽  
Precore Mutant

A new hepatitis B virus vaccine escape mutation in a renal transplant recipient

2007 ◽  
Vol 38 (2) ◽  
pp. 157-160 ◽  
Author(s):  
A. Arzu Sayiner ◽  
Harun Agca ◽  
Aylin Sengonul ◽  
Ali Celik ◽  
Mesut Akarsu
Keyword(s):  
Hepatitis B Virus ◽  
Renal Transplant ◽  
Hepatitis B ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Virus Vaccine ◽  
Escape Mutation ◽  
B Virus ◽  
Hepatitis B Virus Vaccine

FULMINANT HEPATIC FAILURE RESULTING FROM LAMIVUDINE-RESISTANT HEPATITIS B VIRUS IN A RENAL TRANSPLANT RECIPIENT

1999 ◽  
Vol 68 (12) ◽  
pp. 1912-1914 ◽  
Author(s):  
Marion G. Peters ◽  
Gary Singer ◽  
Todd Howard ◽  
Sarah Jacobsmeyer ◽  
Xiaofeng Xiong ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Renal Transplant ◽  
Hepatitis B ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
B Virus

Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A

2009 ◽  
Vol 50 (2) ◽  
pp. 377-387 ◽  
Author(s):  
Da-Li Zheng ◽  
Li Zhang ◽  
Na Cheng ◽  
Xiao Xu ◽  
Qing Deng ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Dna Methyltransferase ◽  
De Novo ◽  
Epigenetic Modification ◽  
X Protein ◽  
B Virus

Fatal necrotizing pancreatitis caused by hepatitis B virus infection in a liver transplant recipient

1995 ◽  
Vol 22 (6) ◽  
pp. 685-690 ◽  
Author(s):  
Antonino Cavallari ◽  
Marco Vivarelli ◽  
Antonia D'Errico ◽  
Roberto Bellusci ◽  
Paolo Scarani ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Transplant Recipient ◽  
Liver Transplant ◽  
Liver Transplant Recipient ◽  
Necrotizing Pancreatitis ◽  
Hepatitis B Virus Infection ◽  
B Virus

scholarly journals Severe de novo Hepatitis B Recovered from Late-Onset Liver Insufficiency with Prolonged Ascites and Hypoalbuminemia due to Hepatitis B Virus Genotype Bj with Precore Mutation

2016 ◽  
Vol 10 (3) ◽  
pp. 553-559 ◽  
Author(s):  
Akira Sato ◽  
Toshiya Ishii ◽  
Fumiaki Sano ◽  
Takayuki Yamada ◽  
Hideaki Takahashi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
De Novo ◽  
Liver Volume ◽  
B Cell Lymphoma ◽  
Hbv Dna ◽  
Hepatocellular Damage ◽  
Precore Mutation ◽  
B Virus ◽  
De Novo Hepatitis B

De novo hepatitis B is associated with a high risk of hepatic failure often resulting in fatal fulminant hepatitis even when nucleotide analogues are administered. A 77-year-old female developed de novo hepatitis B after R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) treatment for diffuse large B-cell lymphoma. Hepatitis B virus (HBV) isolated from the patient was of genotype Bj, with a precore mutation (G1896A) exhibiting an extremely high viral load at the onset of hepatitis. She showed markedly high levels of transaminase with mild jaundice on admission and rapid decrease of prothrombin activity after admission. Although acute liver failure was averted by the administration of entecavir and corticosteroid pulse therapy, liver volume decreased to 860 ml, and marked hypoalbuminemia accompanying massive ascites occurred 2 months after the onset of hepatitis and persisted for 3 months with high levels of HBV DNA and mild abnormal alanine aminotransferase levels. Frequent infusions of albumin solution, nutrition support, and alleviation therapy showed limited effect. However, overall improvement along with HBV DNA reduction was observed after increasing the dose of entecavir and completion of prednisolone that was administered with a minimum dose for adrenal insufficiency. An immediate and sufficient suppression of virus replication with potent antiviral therapy is critical, particularly in patients infected with HBV precore mutation (G1896A) and/or Bj genotype, which may have a high viral replication and direct hepatocellular damage.

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