scholarly journals A Prospective Study of Genital Herpes Simplex Virus Type 2 Infection in Human Immunodeficiency Virus Type 1 (HIV‐1)–Seropositive Women: Correlations with CD4 Cell Count and Plasma HIV‐1 RNA Level

2003 ◽  
Vol 36 (2) ◽  
pp. 207-211 ◽  
Author(s):  
Patty W. Wright ◽  
Craig J. Hoesley ◽  
Kathleen E. Squires ◽  
Angela Croom‐Rivers ◽  
Heidi L. Weiss ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Type ◽  
Cd4 Cell Count ◽  
Immunodeficiency Virus ◽  
Simplex Virus ◽  
A Prospective Study ◽  
Cd4 Cell ◽  
Hiv 1

scholarly journals Human Immunodeficiency Virus Type 1 Disease Progression, CCR5 Genotype, and Specific Immune Responses

1998 ◽  
Vol 5 (4) ◽  
pp. 463-466 ◽  
Author(s):  
Ubaldo Visco-Comandini ◽  
Catharina Hultgren ◽  
Christina Broström ◽  
Markus Birk ◽  
Soo Kim ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Immune Responses ◽  
Cell Count ◽  
Disease Progression ◽  
Wild Type ◽  
Cd4 Cell Count ◽  
Immunodeficiency Virus ◽  
Cd4 Cell ◽  
Hiv 1

ABSTRACT The correlation among the presence of a 32-bp deletion in the CC-chemokine receptor 5 (CCR5) gene, disease progression, and human immunodeficiency virus type 1 (HIV-1)-specific immune responses was analyzed for a cohort of 79 Caucasian HIV-1-infected patients. The CCR5 genotype (CCR5/CCR5 = wild type/wild type or Δ32CCR5/CCR5 = 32-bp deletion/wild type) in peripheral blood mononuclear cells was determined by PCR, followed by sequencing of both wild-type and Δ32CCR5 gene fragments. HIV-1-specific humoral responses to gp41 and V3MN peptides were determined by enzyme immunoassays. The prevalence of the Δ32CCR5 allele was lower among 37 patients with rapid progression (progression to AIDS or to a CD4 cell count of <200 × 106/liter in less than 9 years; P < 0.01) compared to that for 42 patients with slow progression (no AIDS and CD4 cell count of >200 × 106/liter after at least 9 years from infection) or to that for 25 non-HIV-1-infected Swedish blood donors (P < 0.05). No differences were observed in the wild-type CCR5sequences between the different groups of patients. For three analyzed patients, the 32-bp Δ32CCR5 gene deletions were identical. The antibody titers against gp41 and a V3MNpeptide in patients with the Δ32CCR5/CCR5 genotype were not significantly different from those in pair-matchedCCR5/CCR5 controls. However, in 13 analyzed patients, a stronger serum neutralizing activity was associated with the Δ32CCR5/CCR5 genotype. Thus, a CCR5/CCR5genotype correlates with a shortened AIDS-free HIV-1 infection period and possibly with a worse neutralizing activity, without an evident influence on the antibody response to two major antigenic regions of HIV-1 envelope.

scholarly journals Recent Herpes Simplex Virus Type 2 Infection and the Risk of Human Immunodeficiency Virus Type 1 Acquisition in India

2003 ◽  
Vol 187 (10) ◽  
pp. 1513-1521 ◽  
Author(s):  
Steven J. Reynolds ◽  
Arun R. Risbud ◽  
Mary E. Shepherd ◽  
Jonathan M. Zenilman ◽  
Ronald S. Brookmeyer ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Immunodeficiency Virus ◽  
Simplex Virus
Sign in / Sign up

Export Citation Format

Share Document