scholarly journals The Central Nervous System as a Reservoir for Simian Immunodeficiency Virus (SIV): Steady‐State Levels of SIV DNA in Brain from Acute through Asymptomatic Infection

2002 ◽  
Vol 186 (7) ◽  
pp. 905-913 ◽  
Author(s):  
Janice E. Clements ◽  
Tahar Babas ◽  
Joseph L. Mankowski ◽  
K. Suryanarayana ◽  
Michael Piatak, Jr. ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Steady State ◽  
Simian Immunodeficiency Virus ◽  
Asymptomatic Infection ◽  
Immunodeficiency Virus ◽  
The Central Nervous System ◽  
Steady State Levels

scholarly journals Intrathecal Humoral Responses Are Inversely Associated with the Frequency of Simian Immunodeficiency Virus Macrophage-Tropic Variants in the Central Nervous System

2009 ◽  
Vol 83 (16) ◽  
pp. 8282-8288 ◽  
Author(s):  
Elena Ryzhova ◽  
Pyone Aye ◽  
Tom Harvey ◽  
Wei Cao ◽  
Andrew Lackner ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Simian Immunodeficiency Virus ◽  
Humoral Response ◽  
Temporal Course ◽  
Immunodeficiency Virus ◽  
Siv Infection ◽  
The Central Nervous System ◽  
Humoral Responses

ABSTRACT Sustained simian immunodeficiency virus (SIV) infection of the central nervous system (CNS) depends on macrophage-tropic (M-tropic) strains that are often easily neutralizable. The CNS is often thought of as an immunologically privileged site that fosters replication of M-tropic quasispecies. Yet, there are limited data addressing the intrathecal antibody response or the role of the humoral response, in general, to control M-tropic strains. We investigated the temporal course of the intrathecal fusion inhibitory activity against an M-tropic viral variant and found an inverse relationship between the magnitude of this neutralization and the prevalence of M-tropic populations. These studies suggest a role for the humoral response in the suppression of M-tropic viral species in the CNS in experimental SIV infection.

scholarly journals High Frequency of Virus-Specific CD8+ T Cells in the Central Nervous System of Macaques Chronically Infected with Simian Immunodeficiency Virus SIVmac251

2003 ◽  
Vol 77 (22) ◽  
pp. 12346-12351 ◽  
Author(s):  
Marcin Moniuszko ◽  
Charlie Brown ◽  
Ranajit Pal ◽  
Elzbieta Tryniszewska ◽  
Wen-Po Tsai ◽  
...  
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Simian Immunodeficiency Virus ◽  
Rhesus Macaques ◽  
Specific Response ◽  
Immunodeficiency Virus ◽  
The Central Nervous System ◽  
The Brain

ABSTRACT Infection with human immunodeficiency virus or simian immunodeficiency virus (SIV) induces virus-specific CD8+ T cells that traffic to lymphoid and nonlymphoid tissues. In this study, we used Gag-specific tetramer staining to investigate the frequency of CD8+ T cells in peripheral blood and the central nervous system of Mamu-A*01-positive SIV-infected rhesus macaques. Most of these infected macaques were vaccinated prior to SIVmac251 exposure. The frequency of Gag181-189 CM9 tetramer-positive cells was consistently higher in the cerebrospinal fluid and the brain than in the blood of all animals studied and did not correlate with either plasma viremia or CD4+-T-cell level. Little or no infection in the brain was documented for most animals by nucleic acid sequence-based amplification or in situ hybridization. These data suggest that this Gag-specific response may contribute to the containment of viral replication in this locale.

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