An Inversion Method for Measuring β in Large‐Redshift Surveys

2002 ◽  
Vol 579 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Stephen D. Landy ◽  
Alexander S. Szalay
Keyword(s):  
Inversion Method ◽  
Large Redshift ◽  
Redshift Surveys

Formulation, Design and Development of Niosome Based Topical Gel for Skin Cancer

2017 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Skin Cancer ◽  
Drug Release ◽  
Hemorrhagic Cystitis ◽  
The Body ◽  
Cancer Drug ◽  
Inversion Method ◽  
Body Parts ◽  
Basal Cells ◽  
Formulation Design ◽  
Topical Gel

Melanoma is the most dangerous type of skin cancer in which mostly damaged unpaired DNA starts mutating abnormally and staged an unprecedented proliferation of epithelial skin to form a malignant tumor. In epidemics of skin, pigment-forming melanocytes of basal cells start depleting and form uneven black or brown moles. Melanoma can further spread all over the body parts and could become hard to detect. In USA Melanoma kills an estimated 10,130 people annually. This challenge can be succumbed by using the certain anti-cancer drug. In this study design, cyclophosphamide were used as a model drug. But it has own limitation like mild to moderate use may cause severe cytopenia, hemorrhagic cystitis, neutropenia, alopecia and GI disturbance. This is a promising challenge, which is caused due to the increasing in plasma drug concentration above therapeutic level and due to no rate limiting steps involved in formulation design. In this study, we tried to modify drug release up to threefold and extended the release of drug by preparing and designing niosome based topical gel. In the presence of Dichloromethane, Span60 and cholesterol, the initial niosomes were prepared using vacuum evaporator. The optimum percentage drug entrapment efficacy, zeta potential, particle size was found to be 72.16%, 6.19mV, 1.67µm.Prepared niosomes were further characterized using TEM analyzer. The optimum batch of niosomes was selected and incorporated into topical gel preparation. Cold inversion method and Poloxamer -188 and HPMC as core polymers, were used to prepare cyclophosphamide niosome based topical gel. The formula was designed using Design expert 7.0.0 software and Box-Behnken Design model was selected. Almost all the evaluation parameters were studied and reported. The MTT shows good % cell growth inhibition by prepared niosome based gel against of A375 cell line. The drug release was extended up to 20th hours. Further as per ICH Q1A (R2), guideline 6 month stability studies were performed. The results were satisfactory and indicating a good formulation approach design was achieved for Melanoma treatment.

scholarly journals Large-Scale Flows in the Local Universe

1996 ◽  
Vol 168 ◽  
pp. 175-182 ◽  
Author(s):  
D.S. Mathewson ◽  
V.L. Ford
Keyword(s):  
Large Scale ◽  
Velocity Measurements ◽  
Local Universe ◽  
Peculiar Velocities ◽  
Redshift Surveys ◽  
Density Maps ◽  
The Universe ◽  
Great Wall ◽  
Great Attractor ◽  
Streaming Flow

Peculiar velocity measurements of 2500 southern spiral galaxies show large-scale flows in the direction of the Hydra-Centaurus clusters which fully participate in the flow themselves. The flow is not uniform over this region and seems to be associated with the denser regions which participate in the flow of amplitude about 400km/s. In the less dense regions the flow is small or non-existent. This makes the flow quite asymmetric and inconsistent with that expected from large-scale, parallel streaming flow that includes all galaxies out to 6000km/s as previously thought. The flow cannot be modelled by a Great Attractor at 4300km/s or the Centaurus clusters at 3500km/s. Indeed, from the density maps derived from the redshift surveys of “optical” and IRAS galaxies, it is difficult to see how the mass concentrations can be responsible particularly as they themselves participate in the flow. These results bring into question the generally accepted reason for the peculiar velocities of galaxies that they arise solely as a consequence of infall into the dense regions of the universe. To the N. of the Great Attractor region, the flow increases and shows no sign of diminishing out to the redshift limit of 8000km/s in this direction. We may have detected flow in the nearest section of the Great Wall.

scholarly journals Imaging the subsurface using induced seismicity and ambient noise: 3-D tomographic Monte Carlo joint inversion of earthquake body wave traveltimes and surface wave dispersion

2020 ◽  
Vol 222 (3) ◽  
pp. 1639-1655
Author(s):  
Xin Zhang ◽  
Corinna Roy ◽  
Andrew Curtis ◽  
Andy Nowacki ◽  
Brian Baptie
Keyword(s):  
Surface Wave ◽  
Ambient Noise ◽  
Velocity Structure ◽  
Joint Inversion ◽  
Body Wave ◽  
Source Parameters ◽  
Wave Dispersion ◽  
Inversion Method ◽  
Surface Wave Dispersion ◽  
Wave Data

SUMMARY Seismic body wave traveltime tomography and surface wave dispersion tomography have been used widely to characterize earthquakes and to study the subsurface structure of the Earth. Since these types of problem are often significantly non-linear and have non-unique solutions, Markov chain Monte Carlo methods have been used to find probabilistic solutions. Body and surface wave data are usually inverted separately to produce independent velocity models. However, body wave tomography is generally sensitive to structure around the subvolume in which earthquakes occur and produces limited resolution in the shallower Earth, whereas surface wave tomography is often sensitive to shallower structure. To better estimate subsurface properties, we therefore jointly invert for the seismic velocity structure and earthquake locations using body and surface wave data simultaneously. We apply the new joint inversion method to a mining site in the United Kingdom at which induced seismicity occurred and was recorded on a small local network of stations, and where ambient noise recordings are available from the same stations. The ambient noise is processed to obtain inter-receiver surface wave dispersion measurements which are inverted jointly with body wave arrival times from local earthquakes. The results show that by using both types of data, the earthquake source parameters and the velocity structure can be better constrained than in independent inversions. To further understand and interpret the results, we conduct synthetic tests to compare the results from body wave inversion and joint inversion. The results show that trade-offs between source parameters and velocities appear to bias results if only body wave data are used, but this issue is largely resolved by using the joint inversion method. Thus the use of ambient seismic noise and our fully non-linear inversion provides a valuable, improved method to image the subsurface velocity and seismicity.

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