scholarly journals Antibiotic-Resistant Gram-Negative Organisms in Pediatric Chronic-Care Facilities

2002 ◽  
Vol 34 (6) ◽  
pp. 760-766 ◽  
Author(s):  
Karen Lidsky ◽  
Claudia Hoyen ◽  
Ann Salvator ◽  
Louis B. Rice ◽  
Philip Toltzis
Keyword(s):  
Chronic Care ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
Care Facilities ◽  
Gram Negative Organisms

scholarly journals Parental Antibiotic Resistant Gram Negative Organisms (ARGNO) in Pediatric Chronic Care Facilities

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 166A-166A
Author(s):  
Karen Lidsky ◽  
Ann E Salvator ◽  
Philip Toltzis
Keyword(s):  
Chronic Care ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
Care Facilities ◽  
Gram Negative Organisms

scholarly journals Multidrug resistance in the neonatal unit and its therapeutic implications

2016 ◽  
Vol 46 (1) ◽  
pp. 25 ◽  
Author(s):  
Rinawati Rohsiswatmo
Keyword(s):  
Clinical Signs ◽  
Acinetobacter Calcoaceticus ◽  
Neonatal Unit ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
Therapeutic Implications ◽  
Resis Tance ◽  
Fungi Infection ◽  
Gram Negative Organisms ◽  
A Prospective Study

Background Neonatal septicemia constitutes an important causeof morbidity and mortality among neonates in Indonesia. The ex-cessive use of antibiotics may cause antibiotic resistant bacteriaand may cause neonatal fungal infection.Objective To investigate the spectrum of organisms which causeneonatal sepsis and assess their sensitivity to various groups ofdrugs in the neonatal unit.Methods A prospective study conducted on newborn babies de-livered in Cipto Mangunkusumo Hospital, Jakarta from July 2004-May 2005 who presented clinical signs of septicemia were sub-jected for blood culture. Those sensitive to antibiotics for 7 daysyet showed no clinical improvement were also cultured for fungi.Results A total of 499 blood cultures were taken, 320 were posi-tive for bacteria (positivity rate was 65.3%). There were 192 samplescultured for fungi, and the positivity rate was 64% (all for Candidasp). Acinetobacter calcoaceticus was the most common bacteriafound (35.7%), followed by Enterobacter sp (7.0%), and Staphylo-coccus sp (6.8%). Most bacteria showed high degrees of resis-tance to commonly used antibiotics (ampicillin and gentamicin).There were also high degrees of resistance to cephalosporins byboth Gram negative and Gram positive organisms. Only 61.7% ofA. calcoaceticus, and 45.7% of Enterobacter sp were sensitive toceftazidime. Gram negative organisms were also highly resistantto amikacin, but Staphylococcus sp was only moderately resis-tant. Resistance to carbapenem (meropenem and imipenem) var-ied from moderate to low. Drugs which were not used for newbornbabies (quinolones/ciprofloxacin and chloramphenicol) varied frommoderate to high resistance.Conclusion Neonatal sepsis remains one of the major causes ofmortality in our neonatal unit. Most organisms have developedmultidrug resistance, and management of patients infected withthese organisms and especially those with fungi infection are be-coming a problem in developing countries

Effect of Antibiotic Heterogeneity on the Development of Infections with Antibiotic-resistant Gram-negative Organisms in a Non-intensive Care Unit Surgical Ward

2006 ◽  
Vol 30 (7) ◽  
pp. 1269-1276 ◽  
Author(s):  
Yoshio Takesue ◽  
Hiroki Ohge ◽  
Mitsuru Sakashita ◽  
Takeshi Sudo ◽  
Yoshiaki Murakami ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
Surgical Ward ◽  
Gram Negative Organisms

scholarly journals 2297. Epidemiology of Antibiotic-resistant Pathogens and Empiric Treatment Patterns in Community-Onset Sepsis

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S787-S787
Author(s):  
Chanu Rhee ◽  
Sameer S Kadri ◽  
John P Dekker ◽  
Robert L Danner ◽  
Huai-Chun Chen ◽  
...  
Keyword(s):  
Empiric Therapy ◽  
Treatment Patterns ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
Empiric Treatment ◽  
Extended Spectrum ◽  
Gram Negative Organisms ◽  
Inappropriate Empiric Therapy ◽  
Culture Positive ◽  
Community Onset

Abstract Background Guidelines recommend immediate empiric broad-spectrum antibiotics for all patients with suspected sepsis. Understanding the epidemiology of antibiotic-resistant pathogens and empiric treatment patterns in sepsis could inform improvements in antibiotic utilization and outcomes. Methods We identified adults admitted during 2009–2015 to 104 US hospitals in the Cerner HealthFacts dataset who met CDC Adult Sepsis Event criteria and had positive clinical cultures within 2 days of admission. We characterized prevalence and empiric treatment rates for methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococcus (VRE), ceftriaxone-resistant Gram-negative organisms (CRO) (including P. aeruginosa), and extended-spectrum β-lactamase Gram-negative organisms (ESBL). We evaluated associations between in-hospital mortality and either inappropriate empiric therapy (antibiotics inactive against any isolated pathogen) or excessively broad therapy (empiric MRSA or VRE coverage, extended spectrum β-lactam, or carbapenem therapy when targeted organisms were absent), adjusting for baseline characteristics and severity-of-illness. Results The cohort included 17,962 patients with culture-positive sepsis; 2,965 (16.5%) died in-hospital. The most common culture-positive sites were urine (51.2%), blood (41.8%), and respiratory (16.5%). The most common pathogens were E. coli (33.0%), S. aureus (20.9%), and Streptococcus (13.2%) (Figure 1). Most (81.6%) patients received empiric antibiotics active against all isolated pathogens. Empiric therapy was directed at resistant organisms in 67.5% of cases (primarily vancomycin and extended spectrum β-lactams, Figure 2), but resistant organisms were isolated in only 25.2% (MRSA 11.5%, CRO 12.9%, VRE 2.0%, ESBL 0.8%). Both inappropriate empiric therapy and excessively broad empiric therapy were associated with higher mortality on multivariate analysis (OR 1.30, 95% CI 1.14–1.48 and OR 1.20, 95% CI 1.05–1.38, respectively). Conclusion Most patients with community-onset sepsis do not have resistant pathogens, yet empiric broad-spectrum antibiotics are frequently prescribed. Both inappropriate empiric therapy and excessively broad therapy are associated with worse outcomes. Disclosures All authors: No reported disclosures.

Isolation of antibiotic‐resistant gram‐negative organisms from donor respiratory culture does not impact non‐lung solid organ recipient management

2019 ◽  
Vol 33 (8) ◽  
Author(s):  
Esther Benamu ◽  
Marcus R. Pereira ◽  
Sarah Taimur ◽  
Samantha E. Jacobs ◽  
Amy L. Friedman ◽  
...  
Keyword(s):  
Solid Organ ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
Gram Negative Organisms

scholarly journals Epidemiology of Antimicrobial Resistance among Gram-Negative Organisms Recovered from Patients in a Multistate Network of Long-Term Care Facilities

2009 ◽  
Vol 30 (8) ◽  
pp. 790-793 ◽  
Author(s):  
Ebbing Lautenbach ◽  
Roseann Marsicano ◽  
Pam Tolomeo ◽  
Michael Heard ◽  
Steve Serrano ◽  
...  
Keyword(s):  
Long Term Care ◽  
Geographic Location ◽  
Fluoroquinolone Resistance ◽  
Term Care ◽  
Gram Negative ◽  
Care Facilities ◽  
Type Size ◽  
Imipenem Resistance ◽  
Gram Negative Organisms

We identified 1,805 gram-negative organisms in cultures of urine samples obtained over a 10-month period from residents of 63 long-term care facilities. The prevalence of fluoroquinolone resistance in Escherichia coli was 51% (446 of 874 isolates), whereas the preva¬lences of ceftazidime and imipenem resistance in Klebsiella species were 26% and 6% (84 and 19 of 323 isolates), respectively. The prevalence of resistance varied significantly by facility type, size, and geographic location.

Sign in / Sign up

Export Citation Format

Share Document