scholarly journals Tumor Necrosis Factor–α and Interleukin‐10 Promoter Polymorphisms in Epstein‐Barr Virus–Associated Gastric Carcinoma

2002 ◽  
Vol 185 (1) ◽  
pp. 106-109 ◽  
Author(s):  
Ming‐Shiang Wu ◽  
Shih‐Pei Huang ◽  
Yu‐Ting Chang ◽  
Chia‐Tung Shun ◽  
Ming‐Chu Chang ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Tumor Necrosis ◽  
Epstein Barr Virus ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Promoter Polymorphisms ◽  
Barr Virus ◽  
Epstein Barr ◽  
Factor Α ◽  
Necrosis Factor

High tumor necrosis factor-α levels in the patients with Epstein–Barr virus-associated peripheral T-cell proliferative disease/lymphoma

2003 ◽  
Vol 27 (6) ◽  
pp. 493-498 ◽  
Author(s):  
Atsumi Mori ◽  
Satomi Takao ◽  
Jintana Pradutkanchana ◽  
Suparp Kietthubthew ◽  
Winyou Mitarnun ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Epstein Barr Virus ◽  
Tumor Necrosis Factor Α ◽  
Barr Virus ◽  
Proliferative Disease ◽  
Epstein Barr ◽  
Factor Α ◽  
Necrosis Factor

Long-term treatment with methotrexate or tumor necrosis factor α inhibitors does not increase epstein-barr virus load in patients with rheumatoid arthritis

2007 ◽  
Vol 57 (5) ◽  
pp. 762-767 ◽  
Author(s):  
Nathalie Balandraud ◽  
Sandrine Guis ◽  
Jean Baptiste Meynard ◽  
Isabelle Auger ◽  
Jean Roudier ◽  
...  
Keyword(s):  
Tumor Necrosis ◽  
Epstein Barr Virus ◽  
Tumor Necrosis Factor Α ◽  
Term Treatment ◽  
Barr Virus ◽  
Long Term Treatment ◽  
Epstein Barr ◽  
Factor Α ◽  
Necrosis Factor

Inhibition of tumor necrosis factor-α transcription by Epstein-Barr virus

1991 ◽  
Vol 21 (1) ◽  
pp. 203-208 ◽  
Author(s):  
Jean Gosselin ◽  
José Menezes ◽  
Mario D'Addario ◽  
John Hiscott ◽  
Louis Flamand ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Epstein Barr Virus ◽  
Tumor Necrosis Factor Α ◽  
Barr Virus ◽  
Epstein Barr ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Targeted Deletion of Class A Macrophage Scavenger Receptor Increases the Risk of Cardiac Rupture After Experimental Myocardial Infarction

Circulation ◽  
2007 ◽  
Vol 115 (14) ◽  
pp. 1904-1911 ◽  
Author(s):  
Kenichi Tsujita ◽  
Koichi Kaikita ◽  
Takanori Hayasaki ◽  
Tsuyoshi Honda ◽  
Hironori Kobayashi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Experimental Myocardial Infarction ◽  
Cardiac Rupture ◽  
Infarcted Myocardium ◽  
Factor Α ◽  
Necrosis Factor

Background— Class A macrophage scavenger receptor (SR-A) is a macrophage-restricted multifunctional molecule that optimizes the inflammatory response by modulation of the activity of inflammatory cytokines. This study was conducted with SR-A–deficient (SR-A −/− ) mice to evaluate the relationship between SR-A and cardiac remodeling after myocardial infarction. Methods and Results— Experimental myocardial infarction (MI) was produced by ligation of the left coronary artery in SR-A −/− and wild-type (WT) male mice. The number of mice that died within 4 weeks after MI was significantly greater in SR-A −/− mice than in WT mice ( P =0.03). Importantly, death caused by cardiac rupture within 1 week after MI was 31% (17 of 54 mice) in SR-A −/− mice and 12% (6 of 51 mice) in WT mice ( P =0.01). In situ zymography demonstrated augmented gelatinolytic activity in the infarcted myocardium in SR-A −/− mice compared with WT mice. Real-time reverse transcription–polymerase chain reaction at day 3 after MI showed that the expression of matrix metalloproteinase-9 mRNA increased significantly in the infarcted myocardium in SR-A −/− mice compared with WT mice. Furthermore, SR-A −/− mice showed augmented expression of tumor necrosis factor-α and reduction of interleukin-10 in the infarcted myocardium at day 3 after MI. In vitro experiments also demonstrated increased tumor necrosis factor-α and decreased interleukin-10 expression in activated SR-A −/− macrophages. Conclusions— The present findings suggest that SR-A deficiency might cause impairment of infarct remodeling that results in cardiac rupture via insufficient production of interleukin-10 and enhanced expression of tumor necrosis factor-α and of matrix metalloproteinase-9. SR-A might contribute to the prevention of cardiac rupture after MI.

Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-α

1995 ◽  
Vol 25 (10) ◽  
pp. 2888-2893 ◽  
Author(s):  
Johannes Barsig ◽  
Sabine Küsters ◽  
Kathrin Vogt ◽  
Hans-Dieter Volk ◽  
Gisa Tiegs ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Factor Α ◽  
Necrosis Factor
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